SOLICITATION NOTICE
A -- Real Time Exposure Monitor
- Notice Date
- 2/12/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Energy, Pacific Northwest National Laboratory - Battelle (DOE Contractor), PNNL Licensing, PO Box 999, MSIN K9-89, Richland, WA, 99352
- ZIP Code
- 99352
- Solicitation Number
- Reference-Number-11042-E
- Response Due
- 4/1/2002
- Archive Date
- 4/16/2002
- Point of Contact
- Connie Mitzel-Faulk, Licensing Staff, Phone (509) 375-6401, Fax (509) 375-6731,
- E-Mail Address
-
technology@pnl.gov
- Description
- Pacific Northwest National Laboratory (PNNL), operated by Battelle Memorial Institute under contract to the U.S. Department of Energy, solicits interest from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. PNNL may also be available to licensee(s) to assist in further research and development of the technology under a sponsored research agreement or CRADA program. The Technology: Present methods for monitoring exposures use either stationary or personal samplers to measure the concentration of substances in the air. This monitoring fails to account for exposures by routes other than inhalation (for example, ingestion or through the skin). Furthermore, existing methods provide information only on exposure, and do not measure the amount of compound that may have entered the body. Lastly, current methods for determining actual intake of chemicals use urine or blood samples which must be analyzed in a laboratory. This process requires considerable time (often several weeks) before final results can be known. Researchers at PNNL have developed a system to correct these problems and improve overall sensitivity. This system, called the Exposure-to-Risk Monitor (E2RM), allows real time measurement of the amount and type of chemical a person was exposed to and how much of the chemical remains in the body. The E2RM combines a breath inlet device, an ion trap mass spectrometer and software. For most volatile organic chemicals (VOCs), the experimental detection limit is approximately 10 ppb. Once the concentration of the VOC and its metabolite is known, a physiologically based pharmacokinetic software model is used to relate exposure levels to the amount of internal dose received. While other monitoring systems usually measure exposure to chemicals in air, the E2RM can determine actual dose from ingestion and skin absorption, as well as inhalation. The ion trap mass spectrometer can simultaneously track and identify multiple chemicals in the body. The E2RM system provides nearly immediate readout of the personal samples as soon as the exposure occurs. The system scans through the mass range for more than 150 VOCs every 1.5 seconds, and can rapidly analyze the decay in concentration for several VOCs in the breath simultaneously. Note: THIS IS NOT A PROCUREMENT. Any company interested in licensing this technology must respond with a letter of interest (may be submitted by e-mail) no later than 30 days from the publication date of this Notice summarizing the company?s business and technical expertise and motivation for pursuing this opportunity. Companies deemed appropriate will be provided with further information on the technology. Such information may require an executed Nondisclosure Agreement. Respondents wishing to enter into negotiations for a commercial license will be required to submit a business plan for the commercialization of the technology prior to licensee(s) selection and negotiations. Please send letters of interest to the attention of the POC identified within this Notice.
- Record
- SN00025539-W 20020214/020212213117 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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