SOLICITATION NOTICE
A -- Compact, Ruggedized Systems for Sample Preparation in Connection with Cell, Nucleic Acid, Chemical and Protein Detection Systems
- Notice Date
- 2/19/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Energy, Pacific Northwest National Laboratory - Battelle (DOE Contractor), PNNL Licensing, PO Box 999, MSIN K9-89, Richland, WA, 99352
- ZIP Code
- 99352
- Solicitation Number
- Reference-Number-11702-E
- Response Due
- 4/1/2002
- Archive Date
- 4/16/2002
- Point of Contact
- Connie Mitzel-Faulk, Licensing Staff, Phone (509) 375-6401, Fax (509) 375-6731,
- E-Mail Address
-
technology@pnl.gov
- Description
- Pacific Northwest National Laboratory (PNNL), operated by Battelle Memorial Institute under contract to the U.S. Department of Energy, solicits interest from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. PNNL may also be available to licensee(s) to assist in further research and development of the technology under a sponsored research agreement or CRADA program. The Technology: Advances in bioengineering, analytical chemistry, molecular biology and electronics have resulted in a host of very sensitive and ever-shrinking sensors for whole cells, proteins, nucleic acids, inorganic and organic chemicals in a variety of sample types. Such microanalytical "lab-on-a-chip" and mass spectral analysis devices promise to revolutionize health care, medicine, disease diagnostics, food and agriculture, bioprocess monitoring, forensics, and water quality analysis. A problem is that the quest for miniaturized "sensors" and the use of very small sample volumes has all but ignored critical aspects of sample acquisition and preparation, where microorganisms, genes, proteins of interest, or other chemical species (pesticides, herbicides, organic molecules, etc.) represent only a very small portion of the sample volume, exist well below the detection limits of microanalytical sensors and reside in a sample type not immediately conducive to nanofluidic processes. Idealized detection systems require an integrated sample preparation capability that provides collection, lysis (for biological samples), purification and concentration functions for delivery of analytes to these advanced small volume detectors, with the ability to process diverse sample matrices, solution chemistries and target concentrations in a spectrum of genetic and chemical backgrounds. The Battelle-PNNL Enhanced Analyte Delivery System (BEADS) represents the enabling technology for deployment of microanalytical sensors at the point-of-use, whether in a doctor's office, at a patient's bedside, on the food processing line, in the battlefield, or on-line at a wastewater treatment facility. This straightforward solution for bio-chemical/chemical sample preparation envelopes all microbead-based selective chemistries with renewable microcolumns, closing the sample (hundreds of milliliters) to detector (microliter to picoliter) volume gap typical of most chip-based detection systems. Implementation of BEADS sample preparation technology with many biological or chemical detectors results in a simple, precise, reproducible, rugged, portable, fully automated and truly integrated fluidic system for a myriad of clinical, biomedical, environmental, and industrial applications. Advantages: (i) Straightforward solutions to handling large (100s of ml.) to small (micro liter) sample volumes. (ii) Almost all existing bead chemistries (protein, nucleic acid, chemicals) can be used. (iii) Can handle difficult and raw sample types and deliver proteins, nucleic acids, cells, etc. (iv) Adaptable to multiple detector types and configurations. (v) Can easily be made small, rugged, portable and is closed to the environment. Note: THIS IS NOT A PROCUREMENT. Any company interested in licensing this technology must respond with a letter of interest (may be submitted by e-mail) no later than 30 days from the publication date of this Notice summarizing the company?s business and technical expertise and motivation for pursuing this opportunity. Companies deemed appropriate will be provided with further information on the technology. Such information may require an executed Nondisclosure Agreement. Respondents wishing to enter into negotiations for a commercial license will be required to submit a business plan for the commercialization of the technology prior to licensee(s) selection and negotiations. Please send letters of interest to the attention of the POC identified within this Notice.
- Record
- SN00027824-W 20020221/020219221500 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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