SOLICITATION NOTICE
B -- Pathology and Veterinary Support for Preclinical Toxicology Studies
- Notice Date
- 3/11/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Room 604, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- N02CM27009-54
- Response Due
- 5/23/2003
- Archive Date
- 6/7/2003
- Point of Contact
- MaryAnne Golling, Contracting Officer, Phone (301) 435-3819, Fax (301) 402-6699, - Jeannette Johnson, Contracting Officer, Phone (301) 435-3838, Fax (301) 402-8579,
- E-Mail Address
-
mg345x@nih.gov, jj56x@nih.gov
- Description
- The Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the National Cancer Institute is seeking organizations to perform a variety of pathology and veterinary services to support the DTP preclinical toxicology and pharmacology program for anticancer and anti-AIDS drug development. The organization should have the facilities and staff to carry out these efforts and the management expertise to respond to the diverse and changing needs of this contract. As a minimum requirement, the contractors must comply with the FDA's current Good Laboratory Practice Regulations (GLPs), the Geographical Requirement and the Confidentiality of Information Clause. One contract will be awarded and will be administered on a work assignment managed basis. Work assignments will be issued under the "cost-reimbursement, fixed fee, term (level of effort)" contract resulting from this solicitation. Specifically the work assignments to be issued will involve the following: Operation of a repository to hold the pathology materials and raw data generated in past and future toxicology studies. Storage of data on optical medium. Performance of an independent verification (peer review) of the pathological findings by the study pathologist especially with respect to individual diagnoses, drug-relatedness, nomenclature and slide quality. Provide a pathology support program to prepare blocks and slides and conduct histopathological evaluation of tissues; and to go on-site to conduct necropsies, slide preparation or to assist the Project Officer in project evaluation. This includes providing expertise in special techniques to assess cardiotoxicity, neurotoxicity, nephrotoxicity; Conduct human and animal tissue binding studies that are required by the FDA for antibodies; Measure tissue distribution of a test article using newer techniques, such as, polymerase chain reaction (PCR), -galactosidase expression and luciferase expression; Isolate total RNA and poly-A RNA to be used for PCR and/or DNA microarray technology; Storage, maintenance and shipment of Government infusion equipment to other DTP contractors; Development and implementation of new surgical or other procedures for drug administration or sampling; instruction in these procedures; or performance of these procedures in actual animal studies; Conduct site visits to the DTP toxicology contractor laboratories to evaluate pathology laboratories, animal care programs or to investigate pathology or animal care problems; and Support the T&PB toxicology effort as required through the preparation of study protocols, study monitoring and report evaluation. The principal investigator should be a board certified veterinary pathologist or veterinarian with at least three years experience with similar programs. The Government anticipates one award to be funded on an incremental basis. This is a re-compete of a current contract, N02-CM-77027. The NAICS code is 541940. The solicitation is scheduled for release on or about April 22, 2002 and it is anticipated that a contract will be awarded for a seven year period. The RFP may be accessed through the Internet site at http://amb.nci.nih.gov/ It is the offerors responsibility to monitor the above Internet site for the solicitation release and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDENTS. Offerors may not e-mail or fax in their proposals in response to this RFP. No collect calls will be accepted.
- Place of Performance
- Address: Contractor's facility
- Record
- SN00038946-W 20020313/020311213208 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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