SOLICITATION NOTICE
66 -- 3-Axis Gantry Robot sub-system...
- Notice Date
- 4/11/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Room 604, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-20037-NG
- Response Due
- 4/26/2002
- Archive Date
- 5/11/2002
- Point of Contact
- Malinda Holdcraft, Purchasing Agent, Phone (301) 402-4509, Fax (301) 402-4513, - Caren Rasmussen, Lead Contract Specialist, Phone (301) 402-4509, Fax (301) 402-4513,
- E-Mail Address
-
holdcram@exchange.nih.gov, rasmusc@mail.nih.gov
- Description
- The National Cancer Institute (NCI) Genetic Branch, plans to procure a Chip Writer Colony Arraying System with Virtek Vision, 785 Bridge Street Waterloo, Ontario, Canada N2V 2K1. The North American Industry Classification System code is 421450 and the business size standard is 100 employees. The NCI Genetic Branch research, focuses on defining the molecular determinants of mitosis and checkpoint responses in the budding yeast S. cerevisiae. NCI wishes to expand and develop yeast/human cross species approaches to identify evolutionary conserved genes in these pathways. The relevance of our studies is reinforced by the fact that, to date, about one-third of all human disease-associated genes have functional homologs in yeast including, mammalian homologs of yeast genes required for chromosome segregation and DNA damage response pathways. These studies suggest that detailed analysis of chromosome segregation and checkpoint responses in budding yeast will help us understand how these processes operate (health) or fail to operate (disease) in humans. The completion of the genome sequences of S. cerevisiae has resulted in a huge library of resources. One of these is the availability of the entire set of isogenic deletion strains for both essential (heterozygous diploids) and non-essential (haploid) genes. This resource has been widely used by yeast researchers for genetic, biochemical and cell biology approaches. It has been designed by researchers from the University of Toronto, Canada. This screen will allow NCI to perform genome wide screens that can be very tedious if done manually. Genetic screens can take a year to several years if done manually. A table top model of a robot that allows one to expeditiously perform these screens has been designed by Virtek. NCI will be using the Virtek ChipWriter for several experiments to list a few: 1) synthetic lethal screen with a deletion strain for hug1 strain, 2) synthetic dosage lethality with checkpoint and kinetochore components and, 3) generation of a chromosome missegregation mutant collection. Minimum Requirements: 1) compact design with totally intuitive graphical user interface software to let users easily and efficiently perform arraying and replicating of colonies, 2) replicator heads with 96/384/768 pins available for colony arraying in sterile, dust-free environment with regulated humidity and positive pressure within the environmental chamber, 3) three wash stations, sonicator, and an air-dryer nit are available for easy cleaning of pins, 4) automatic lidding and delidding of microwell plates to prevent cross-contamination of samples and, 5) high precision XYZ robot with micron accuracy (+/- 3 microns repeatability, and up to 10 microns absolute accuracy). This will allow creating colony arrays that can not be obtained by hand-held replicator. Virtek Vision is the only known source to the NCI that can provide the aforementioned instrument. It is believed that Virtek Vision is the only company that has custom designed the instrument for research on budding yeast. This instrument is unique with no comparable instruments on the market. This notice is not a request for competitive quotation. However, if any interested party believes it can meet the above requirements, it may submit a statement of capabilities. The capability statement and any other furnished information must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can fully meet the requirements. Capability statements must be received in the contracting office by 1:00 PM EST, (local Washington DC time) on April 26, 2002. If you have any questions, please submit them in writing to Malinda Holdcraft on electronic mail at holdcram@exchange.nih.gov or by fax, 301-402-4513. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Information received shall be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. Faxed capability statements will not be accepted. If submitting capability statements, please provide one original and two copies to Malinda Holdcraft, NIH/NCI/RCB, 6120 Executive Blvd. 6th floor Suite 4, Rockville, Maryland 20852-7194. ***Please note, if submitting questions by fax, that the NCI/RCB fax machine will be out of service April 18 through April 21, 2002. It is highly recommended that any interested party submit questions via electronic mail, as stated above.
- Place of Performance
- Address: NIH/NCI, 9000 Rockville Pike, Bethesda, MD
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN00056970-W 20020413/020411213209 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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