Loren Data's SAM Daily™

FBO DAILY ISSUE OF JUNE 30, 2002 FBO #0210
SOLICITATION NOTICE

B -- Special studies and analysis

Notice Date

6/28/2002
 

Notice Type

Solicitation Notice
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases/AMOB, 6700-B Rockledge Drive, Bethesda, MD, 20892-7605
 

ZIP Code

20892-7605
 

Solicitation Number

NOI2077
 

Response Due

7/29/2002
 

Archive Date

7/29/2002
 

Point of Contact

Carolyn Sentz, Contracting Officer, Phone 301-402-2284, Fax 301-480-3695, - James Smith II, Administrative Assistant, Phone 301-402-2284, Fax 301-480-3695,
 

E-Mail Address

csentz@niaid.nih.gov, jsmith@niaid.nih.gov
 

Description

17. This is a combined synopsis/solicitation notice of intent for commercial item prepared in accordance with the Format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are not being requested and a written solicitation will not be issued. The solicitation number is issued as a Notice of Intent (NOI2077). The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 01-07. The National Institute of Allergy and Infectious Diseases (NIAID) intends to procure on a sole source basis with Biovest International Inc. for Recombinant Protein Production acusyst X-cell 6. This is not a Small Set-Aside. The associated North American Industry Classification System (NAICS) code for this acquisition is 541380 and the Small Business Standard Size is 6 Million. The purpose of this requirement is to develop recombinant protein from mammalian cells for its potential use in anti-HIV therapy. As part of an ongoing project, Design, expression and evaluation of a highly potent anti-HIV-1 recombinant fusion protein, we require large-scale expression of a recombinant protein from mammalian cells. We have developed a recombinant protein that exhibits potent anti-HIV activity. In order to test the potential efficacy of this protein in a primate model of HIV, we require that it be produced in quantities achievable only at a large-scale production facility. The NIAID will provide the contractor with the recombinant cell line for the production of recombinant protein and in addition to the data regarding levels of production parameters adjusted to maximal levels of production. This protein will be employed in an in vivo primate model of HIV. Finally, protein is produced in a specific mammalian expression system it is necessary that the protein be produced in hollow-fiber bioreactors. As a continuation of recombinant protein from mammalian cells for its potential use in anti-HIV therapy and mammalian expression system it is essential that use of these same proteins from Biovest International Inc. be continued. At this time only Biovest International can provide this required testing service. Vendor shall perform the following tasks. 1) The contractor shall culture the cell line in hollow-fiber cartridge-based bioreactors, which will then be ?fed? with serum-containing medium on a daily basis. 2) The contractor shall use standard protocols to collect culture supernatants containing the desired proteins. These supernatants will be temporarily frozen and stored. 3) The contractor shall ship the product back to our laboratory for further purification and characterization. 4) The contractor shall provide monthly reports on the status of production runs. 5) The contractor shall provide samples of production runs upon request that will aid in our evaluation of the progress toward the production of sufficient quantities of protein to meet our needs. Period of Performance August 5, 2002 to November 5, 2002. A firm fixed-price purchase order is anticipated to result from the award of this solicitation. Place of delivery and FOB Point is Bethesda, MD. The following FAR provisions and clauses apply to this acquisition: FAR 52.212-1 Instructions to Offerors- Commercial Items; FAR 52.212.3 Offeror Representations and Certifications-Commercial Items; FAR 52.212-4 Contract Terms and Conditions Commercial Items; FAR 52.212-5 Contract Terms and Conditions Required to Implement Status or Executive Orders-Commercial Items; and FAR 52.225-3 Buy American Act. A completed copy of provisions at FAR 52.212-3 Offerors Representations and Certifications Commercial Items must be included. Copies of the aforementioned clauses are available upon request. Any response to this NOI must be mailed to the Point of Contact indicated below. Offers must be submitted not later than 5:00 P.M. Daylight Savings Time (DST), July 29, 2002. For delivery through the Postal Service, the address is NIH/NIAID/AMOB, 6700B Rockledge Drive/MSC7605, Room 1130, Bethesda Maryland 20892-7605. Electronic submission will not be accepted. Requests for information concerning this requirement are to be addressed to Linda Taylor at (301) 402-2282. Collect calls will not be accepted. All responsible sources may submit an offer that will be considered by the Agency.
 

Place of Performance

Address: Bethesda, Maryland

Zip Code: 20892

Country: USA
 

Record

SN00101421-W 20020630/020628213116 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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