SOLICITATION NOTICE
A -- Basic and Clinical Approaches to Controlling Human Respiratory Pathogens
- Notice Date
- 7/16/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Branch 6700-B Rockledge Drive, MSC 7612 Room 2230, Bethesda, MD, 20892-7612
- ZIP Code
- 20892-7612
- Solicitation Number
- RFP-NIH-NIAID-DMID-03-05
- Response Due
- 11/18/2002
- Point of Contact
- Nancy Hershey, Contracting Officer, Phone 301-496-0193, Fax 301-402-0972, - Jacqueline Holden, Senior Contracting Officer, Phone 301-496-7119, Fax 301-402-0972,
- E-Mail Address
-
NHershey@niaid.nih.gov, jh55b@nih.gov
- Description
- The Division of Microbiology and Infectious Diseases (DMID), of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is re-competing and expanding their current contract with the Baylor College of Medicine, Contract No. N01-AI-65298. This solicitation will be a full and open competition, NAICS Code 541710, 500 employees. This RFP solicits proposals for respiratory pathogens research units to support the infection prevention program of the Respiratory Diseases Branch, DMID. The Government has a need to continue this effort and expand the respiratory pathogens unit as part of the Bio-defense Research Agenda. The focus of these units will include: 1) increased capacity to conduct pre-clinical and clinical research activities on emerging and re-emerging bacterial and viral respiratory pathogens with an emphasis on multi-drug resistant organisms and novel influenza vaccines; 2) enhanced capability to evaluate vaccines, therapeutics, and novel strategies to enhance the protective human immune response; 3) emphasized integration of human mucosal immunity with clinical research; and 4) emphasized research on product development activities. Separate proposals are solicited for separate parts of this solicitation: Part A - Bacterial Respiratory Pathogens Research Unit (BRPRU) and Part B - Viral Respiratory Pathogens Research Unit (VRPRU). An offeror may respond to either Part A or Part B, or both. It is anticipated that a total of three contracts will be awarded to successful offerors demonstrating capability of responding to the requirements of this solicitation. It is anticipated that three (3) cost-reimbursement, completion-type contracts will be awarded for a period of seven (7) years at an estimated level of effort 24.90 FTEs for each year (Part A) and 19.90 FTEs for each year (Part B). The Part A bacterial research unit will focus on the major themes of: bacterial carriage, progression to lower respiratory tract disease, and development of prevention strategies that optimize the protective immune response (including innate and mucosal immunity). The BRPRU unit will also conduct clinical studies, which focus on these major themes, including Phase I and Phase II clinical trials of candidate vaccines and therapeutics. In addition, this unit must have the capacity to conduct clinical challenge studies with bacterial respiratory pathogens. The Part B viral research unit will focus on the major themes of: viral pathogenesis, evaluation of new and/or improved vaccines and therapeutics, and development of strategies that optimize the protective immune response. The VRPRU will also conduct clinical studies that focus on these major themes, including the conduct of Phase I and Phase II clinical trials of candidate vaccines and therapeutics. In addition, this unit must have the capacity to conduct human challenge studies with viral and respiratory pathogens, including influenza and respiratory syncytial virus (RSV). Once awarded, the Respiratory Pathogens Research Units (RPRUs) will become a part of a multi-disciplinary Respiratory Pathogens Research Network (RPPN) that will also include contracts that support bacterial and viral Respiratory Pathogens Research Reference Laboratories. These laboratories will provide standardized key serological assays for use in vaccine studies and distribution of reagents for the measurement of the human immune response to bacterial or viral respiratory pathogens. The Respiratory Pathogens Reference Laboratories will be awarded through a separate solicitation entitled Respiratory Pathogens Research Reference Laboratory Support , RFP-NIH-NIAID-DMID-03-37 that is also posted at this time. RFP-NIH-NIAID-DMID-03-05, will be available electronically on the CMB Homepage on or about July 24, 2002, may be accessed through the NIAID Contract Management Branch (CMB) Home Page at http://www.niaid.nih.gov/contract and will be posted on Fed Biz Opps: www.fedbizopps.gov. Any responsible offeror may submit a proposal that will be considered by the Government. This announcement does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. Point of Contact Nancy Hershey, Contracting Officer, Phone 301-496-0193, Fax 301-402-0972, Email NHershey@niaid.nih.gov - Jacqueline Holden, Senior Contracting Officer, Phone 301-496-7119, Fax 301-402-0972, Email JH55b@nih.gov.
- Record
- SN00117347-W 20020718/020717061637 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |