SOLICITATION NOTICE
A -- Efficacy Studies of Chemopreventive Agents in Animal Models, WS 98-102
- Notice Date
- 7/17/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- RFP-N01-CN-35007-72
- Response Due
- 9/19/2002
- Point of Contact
- Jacqueline Ballard, Contracting Officer, Phone (301) 435-3795, Fax (301) 402-8579,
- E-Mail Address
-
jb335w@nih.gov
- Description
- DESC: The National Cancer Institute, Division of Cancer Prevention, (DCP) Chemoprevention Agent Development Research Group (CADRG) is interested in evaluating inhibitors or potential inhibitors of any stage of carcinogenesis, in order to identify potential chemopreventive agents. Such agents are to be further evaluated in appropriate toxicological and/or clinical settings. The CADRG has established a clearly defined integrated plan for the evaluation of chemopreventive agents. This plan delineates detailed criteria for classifying the quantity and quality of information that currently exists on any chemopreventive agent and thus defines what additional information and investigations are required to qualify the agent's experimental use in intervention trials of human cancer. The primary purpose of this RFP is to further evaluate chemopreventive agents for which there exists at least one published report regarding their effectiveness in inhibiting carcinogenesis. The object of these studies is to establish the general efficacy of the chemopreventive agent in animal model systems representing selected target organs, different species, and different carcinogens. This RFP involves five Workstatements (Nos. 98-102). Certain study design characteristics apply to the specific Workstatements under this RFP. Most of the requirements for the Workstatement study design will be detailed in the specific workstatement. Each workstatement will have a specific period of performance. The workstatements are: WS 98 - Efficacy studies of selected chemopreventive agents administered by aerosol in the Syrian Golden hamster lung model; WS 99 - Efficacy testing in the p27kip1 knockout mouse prostate tumor model with selected chemopreventive agents; WS 100 - Chemopreventive studies in an IGF1 mediated of mouse prostate cancer; WS 101 - Efficacy of Chemopreventive agents in a hgf mediate induced model of melanoma; WS 102 - Effacy of topically applied chemopreventive agents and diet in SKH-1 mice: a chemoprevention model for basal cell carcinoma. It is anticipated that this RFP will be available electronically about August 1, 2002 to all current MA Holders. In order to be considered for award, all offerors shall be Holders of an Efficacy Studies of Chemopreventive Agents in Animal Models Master Agreement and members of this pool as of the release date of this RFP. All questions should be directed, via facsimile or e-mail to Jacqueline Ballard, Contracting Officer, Prevention and Control Population Sciences Contracts Section, Research Contracts Branch, National Cancer Institute, NIH, Executive Plaza South, Room 6000, 6120 Executive Boulevard, MSC 7195 Rockville, Md. 20852. Phone: 301-435-3795; Fax: 301-402-8579; Email address: ballardj@mail.nih.gov . The North American Industry Classification System (NAICS) code is 541710. All request should reference the RFP No. N01-CN-35007-72. No collect calls will be accepted. Number Note 26 - Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify their interest and capability to the contracting officer to satisfy the Government's requirement with a commercial item within 15 days of this notice.
- Record
- SN00118493-W 20020719/020717213436 (fbodaily.com)
- Source
-
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