SOURCES SOUGHT
A -- Database development and evaluation of 16s rDNA gene sequence data for rapid identification of bacterial isolates in clinical and public health laboratories.
- Notice Date
- 12/12/2002
- Notice Type
- Sources Sought
- Contracting Office
- Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, GA, 30341-4146
- ZIP Code
- 30341-4146
- Solicitation Number
- Reference-Number-SS-001
- Archive Date
- 2/8/2003
- Point of Contact
- Michael Detmer, Supervisory Contract Specialist, Phone (404) 639-0714, Fax (404) 638-5461, - Michael Detmer, Supervisory Contract Specialist, Phone (404) 639-0714, Fax (404) 638-5461,
- E-Mail Address
-
MDetmer@cdc.gov, MDetmer@cdc.gov
- Description
- This is a request for information only. It is not a request for proposal (RFP) and does not commit the Government to issue a solicitation, make an award, or pay any costs associated with responding to this request for information. All submitted information shall remain with the Government and will not be returned. The Centers for Disease Control (CDC) has developed a 16s ribosomal DNA (16s rDNA) sequence database of almost 1000 reference strains and difficult to identify clinical isolates of aerobic gram-positive and gram-negative bacteria. Although the early application of 16s rDNA sequencing was in taxonomic studies, the value of this approach for identification of bacterial isolates has become apparent. Partial and complete sequencing of the bacterial gene coding for 16s rDNA is now used for rapid identification of bacterial species (e.g., Escherichia coli). This technique has been used extensively in research and reference bacteriology laboratories and has proven to be a powerful phylogenetic tool, applicable to all bacteria. Recent advances in automated sequencing methods have potentially brought 16s rDNA sequencing within reach of clinical laboratories seeking rapid identification of clinical isolates, particularly if these are slow-growing or otherwise difficult to identify using standard microbiological procedures. CDC is seeking partners for a potential collaborative research project that would result in making the CDC data widely available for identification of clinical isolates, both in the reference laboratory and clinical diagnostic laboratory settings. It is expected that initially this will involve making the CDC database searchable, and/or combining with other existing databases, for use by laboratories which can perform 16s rDNA sequencing. This would be followed by an evaluation to determine the clinical utility of this approach. The CDC goal is to establish, and have maintained, a comprehensive database of existing and future data, that would be widely available, and effectively utilized for rapid identification of bacteria in clinical laboratories and State and local Public Health Laboratories. Interested organizations are encouraged to submit information that would be sufficient to assess the organizations ability to pursue research in the above area. Standard capability statements and marketing information is not desired. Submitted information should focus on previous experience and current capabilities in the relevant areas. Only those organizations with a strong background and experience in developing and maintaining DNA sequence databases should respond. It is intended that CDC will review the submitted information to assess the possibility of pursuing a collaborative or cooperative research and development agreement. Responses should be prepared in MS Word format, not exceeding ten pages in length. Electronic responses via e-mail can be sent to MMD4@CDC.GOV by 4:00pm eastern time, January 24th, 2003. Questions regarding this request for information can be directed to Michael Detmer at the above e-mail address or by calling 404 639-0714.
- Record
- SN00222205-W 20021214/021212213501 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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