MODIFICATION
A -- LUNG TISSUE RESEARCH CONSORTIUM: TISSUE PROCESSING AND DISTRIBUTION CENTER
- Notice Date
- 2/28/2003
- Notice Type
- Modification
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-HR-04-09
- Response Due
- 5/22/2003
- Archive Date
- 6/6/2003
- Point of Contact
- Joanne Deshler, Contracting Officer, Phone (301) 435-0340, Fax (301) 480-3338, - Fred Ettehadieh, Contract Specialist, Phone (301) 435-0340, Fax (301) 480-3338,
- E-Mail Address
-
jd52g@nih.gov, fe19w@nih.gov
- Description
- The National Heart, Lung, and Blood Institute (NHLBI), National Institute of Health (NIH), will make available a request for proposal (RFP) to interested offerors with the ability to serve as a Tissue Processing and Distribution Center (TC) for a new five-year multi-center research program, the Lung Tissue Research Consortium (LTRC). The overall objective of the LTRC is to enable better management of lung diseases by increasing understanding of the pathogenetic mechanisms of these diseases through molecular histopathological studies of human lung tissues with and without disease. The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the Consortium. Primary emphases will be on chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. Collections of specimens will be linked to extensive, individual clinical data appropriate to the particular disease. Donor subjects will be recruited for specific enrollment groups that are designed to address important research questions. The consortium will be comprised of a TC; Clinical Centers (CC), RFP-NHLBI-HR-04-08; a Radiology Center (RC), RFP-NHLBI-HR-04-10; and a Data Coordinating Center (DCC), RFP-NHLBI-HR-04-11. Offerors are strongly encouraged to read the RFPs for all of these components of the LTRC to better understand the overall structure and function of the Consortium. The TC shall prepare protocols for specimen procurement, processing, transport, storage, and distribution; train CC personnel regarding specimen handling, processing, and shipping to the TC; conduct site visits to assure that LTRC protocol procedures are followed; perform diagnostic histopathological analysis of lung tissues; obtain relevant quantitative measures of disease presence or severity (e.g., mean chord length) in lung tissue specimens; perform quality control/quality assurance tests and report results to the DCC; store specimens received; perform diagnostic, light-microscopic, histopathological analyses of CC lung tissues by a board-certified pathologist; and prepare and distribute specimens and collections of specimens to researchers. The Principal Investigator of the TC shall participate fully in the activities of the Steering Committee to: identify lung conditions other than COPD and idiopathic pulmonary fibrosis for which lung tissues are needed for research and may be available from External Tissue Contributors (ETCs); define inclusion/exclusion criteria for auxiliary groups of donor subjects appropriate for research of these conditions; set target numbers of donor subjects for each group, determine what tissues are to be accepted (e.g., surgical specimens, transbronchial biopsies), and determine what data should be extracted from the donor subjects? medical records in each of these groups; identify any problems with existing LTRC procedures and any difficulties that may interfere with LTRC objectives; devise strategies to improve procedures and overcome difficulties, and submit recommended changes in policies and protocols to the Scientific Advisory Committee for evaluation. The TC shall maintain an inventory of specimens and specimen collections available for distribution to investigators; transport specimens and specimen collections to LTRC investigators and external researchers as directed by the DCC and in accordance with the LTRC Protocol Manual; work with other LTRC investigators to prepare reports and manuscripts for publication. ******This is not a RFP and the Government is not committed to award a contract pursuant to this notice. It is anticipated that RFP-NHLBI-HR-04-09, Lung Tissue Research Consortium: Tissue Processing and Distribution Center (TC), will be available on or fifteen (15) days after the publication of this notice through the NHLBI Website at: http://www.nhlbi.nih.gov/funding/inits/index.htm#rfp and posted on FedBizOpps at: http://www.fedbizopps.gov. The North American Industry Classification System (NAICS) code is 541710 with a business size standard of 500 employees. No collect calls will be accepted. NOTE: THIS NOTICE WAS NOT POSTED TO FEDBIZOPPS.GOV ON THE DATE INDICATED IN THE NOTICE ITSELF (28-FEB-2003). IT ACTUALLY FIRST APPEARED ON THE FEDBIZOPPS SYSTEM ON 03-MAR-2003. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Record
- SN00268548-W 20030305/030303213837 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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