MODIFICATION
A -- Defense Sciences Research and Technology
- Notice Date
- 3/13/2003
- Notice Type
- Modification
- Contracting Office
- Other Defense Agencies, Defense Advanced Research Projects Agency, Contracts Management Office, 3701 North Fairfax Drive, Arlington, VA, 22203-1714
- ZIP Code
- 22203-1714
- Solicitation Number
- BAA03-02
- Response Due
- 11/7/2003
- Archive Date
- 11/8/2003
- Point of Contact
- Steven Wax, Deputy Director, Defense Sciences Office, Phone 703-696-2281, Fax 571-218-4553,
- E-Mail Address
-
none
- Description
- THE VIRTUAL SOLDIER, SOL BAA 03-02, Addendum 4, DUE 043003, POC: DR. RICHARD SATAVA, DARPA/DSO, Fax: (571) 218-4629, Email: baa03-02@darpa.mil, URL: www.darpa.mil/baa/#dso. THE VIRTUAL SOLDIER Program represents a DSO thrust area that will comprise a multi-disciplinary, multi-pronged approach to establish a new capability that will revolutionize medical care to support the soldier. The program will create the mathematical modeling approaches to develop an information (computational) representation of an individual soldier (a holographic medical electronic representation or holomer) that can be used to augment medical care on and off the battlefield with a new level of integration. This virtual soldier will be based upon a highly complex model that is derived from biologically driven principles and populated with properties that are extracted from evidence-based data. The initial Phase 1 effort will consist of a two-component, three-dimensionally displayed model, 1) An Organ-tissue System model component and; 2) a Properties Level model component. Once derived, the virtual soldier will provide multiple capabilities, including but not limited to automatic diagnosis of battlefield injuries (this Phase 1), prediction of soldier performance, testing and evaluation of non-lethal weapons, and virtual clinical trials. In order to create a virtual soldier, integrated, inter-disciplinary teaming will be necessary; proposers are welcome to submit a single institution or multi-institution, multi-disciplinary proposal that covers one or several of the components. All researchers in this virtual solider program are expected to collaborate extensively with other participants during the DARPA sponsored meetings and throughout the development toward the single demonstration (see below), in order to integrate the technologies and meet the program goals. The following areas are required in order to construct a holomer and conduct the Phase 1 demonstration: (1) Global Architecture ?V A generalizable, scalable ontology to characterize the holomer and provide the architecture that will be the infrastructure that integrates all other components (organ-tissue system model and properties-level model). The milestone will be an architecture with descriptors for each major organ/system that assigns attributes to each system, incorporates all levels of properties (genetic, molecular, biochemical, cellular, physiologic, organ, tissue and whole body) and provides inter-operable cross-linkages from level to level and system to system. (2) Organ-tissue system model component. This model component will consist of the different organs and tissue systems (e.g., heart, lung, liver, etc.) that need to be modeled and integrated at each level (see below). Because of the enormous complexity of the human body, the organ systems to be modeled in this Phase 1 will be certain individual organs of the chest cavity, specifically the chest wall, heart, great vessels, lung and aorta; subsequent Phases will address other organs and tissues (e.g., liver, kidney, hemopoetic, lymphatic, etc.) systems. The milestone will be a full 3-D representation of the chest cavity with segmented heart, great vessels, lung and aorta of a generic model (visible human dataset is acceptable) which is fully interactive for display, query and modeling of a penetrating injury of each of the structures. (3) Properties-levels model. These models will consist of the different levels of representation (genetic, molecular, cellular, physiologic, organ or total body) that must be modeled within each organ-tissue system. For Phase 1 (to add properties to the heart only) the levels to be modeled may include the cellular, molecular (biochemical), physiologic (including electrophysiology, mechanics, hemodynamics, etc.) and total organ structure. Excluded are genetic, tissue and cardio-vascular system (only the heart is to be modeled with properties, the remainder of organs mentioned above will only have their anatomic shapes modeled). The modeling dynamics must be able to respond to a penetrating wound of the heart by predicting the expected response at each level to the wounding forces. (4) Automatic segmentation of organ-tissue systems. The individual organ-tissue system models (e.g., heart, lung, great vessels, etc.) on the whole-organ level must be automatically derived (segmented) from commercially available imaging modalities (Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), etc.) in a form that can be visually displayed in three dimensions as the organ. In addition, the database that provides the dataset for automatically storing and displaying the segmented image of the organ must also be capable of storing the data for every property of each organ. In Phase 1, only the heart will be segmented and stored with the properties described above. (5) Holomer display and interface. The display of the virtual soldier must bear a high-fidelity resemblance to the real soldier data - for Phase 1, the image of the heart must look exactly like the actual heart (see demonstration below). In addition, interaction with the display must be absolutely intuitive ?V manipulating and interacting with the holomer must resemble as close as possible the actions that would be performed on a real person. (6) Holomer storage, retrieval and interoperability. The dataset for the project must be storable on the U.S. Army Personnel Information Carrier (PIC or ??electronic dog tag??). This data must be able to be transferred to a number of platforms and medical records (open architecture) to include the medic hand-held computer, standard laptop, standard desktop personal computer, DoD hospital-based medical record and Veterans Administration (VA) electronic medical record. (7) Demonstration. There will be a single demonstration that meets not only the individual project milestones, but also the integration of the individual projects into a unified program. Since the success of the Phase 1 depends upon the successful prediction of outcomes, each of the components will not be considered successful unless the entire demonstration succeeds; therefore consensus of operating standards and interface methodology and continuous interaction among the participants is required. The demonstration that will be conducted in18 months to prove the validity of the virtual soldier (holomer) concept will be in a porcine model of an event from the Wound Data and Munitions Effectiveness Team (WDMET) database. After a CT scan of the porcine chest, the anatomic model of the heart (and representational models of the chest wall, lung, great vessels and aorta) will be derived through automatic segmentation and the properties (on the properties-levels agreed upon) will be added to only the heart database. This will be stored on a PIC. The selected event will be initiated, and there will be continuous monitoring until completion of protocol. There will be two model comparisons made, which must have at least a p> 0.80 correlation: 1) The structural abnormalities of the modeled heart must predict the actual anatomic abnormalities documented at protocol completion and 2) The physiologic response of the event model of the cardiovascular system must follow and predict the actual recording of the same parameters during the demonstration of the event. The submission formatting and requirements of the master BAA 03-02 are to be considered in addition to the guidelines provided herein. The minimum requested for your proposal to this Addendum is: Part I - Technical 1)Problem definition ?V in one-two paragraphs state clearly what problem you will solve; 2) Previous experience/success in the specific subject matter area (component) ?V maximum one page; 3) Technical Solution Summary of your innovative solution to the problem, including how you will integrate with the other component areas ?V no more than two pages; 4) Tasks ?V simply list (in outline form) the tasks that will be performed (listed as Task 1, 2 etc.) with subtasks and the last subtask as a specific deliverable; 5) Statement of Work (SOW) ?V for each Task listed above, describe the problem to be solved, how you will solve the problem and what are the possible barriers to success ?V this is the technical description of the work which will primarily determine the acceptability of the proposal (images and diagrams are encouraged); 6) Timeline graph ?V listing both the milestones and deliverables; 7) Facilities/equipment ?V very brief one or two paragraph description of resources; 8) Personnel qualifications - of the PI and major participants (maximum of 2 pages each). You may list (with a one sentence description) any advisors/consultants that bring unique qualifications, however no curriculum vitae should be included. Part II - Budget. Proposers must submit an original and 4 hard copies of the full proposal plus two electronic copies (i.e., two separate disks) of the full proposal in PDF - preferred, though MS-Word readable, HTML, or ASCII format, each on a single CD-ROM, 3.5 inch High Density MS-DOS formatted 1.44 Megabyte (MB) diskettes, or 100 MB Iomega Zip?? disks will be accepted. Each proposal and disk must be clearly labeled with BAA 03-02, addendum 4 ?V The Virtual Soldier, proposer organization, proposal title (short title recommended). Submissions of full proposals via electronic mail (e-mail) will not be accepted. The full proposal (original and designated number of hard and electronic copies) must be submitted to DARPA/DSO, (Attn.: BAA 03-02 ?V The Virtual Soldier), 3701 North Fairfax Drive, Arlington, VA 22203-1714 on or before 4:00 p.m., Eastern Time (ET), April 30, 2003, in order to be considered under this addendum. Proposals received after that date may be considered under the open BAA but not this addendum. All proprietary information should be clearly marked on the full proposal. It is the policy of DARPA to treat all proposals as competitive information and to disclose their contents only for the purpose of evaluation. Standard proprietary disclaimers notwithstanding, proposals may be reviewed by non-Government technical experts who have signed a non-disclosure agreement (NDA) with DARPA, unless the specific phrase "TO BE REVIEWED BY GOVERNMENT EMPLOYEES ONLY" appears on the cover sheet. In any case, personnel under exclusive contract with DARPA who have completed the appropriate nondisclosure agreements will handle the proposals for administrative purposes. Proposals will not be returned to proposer. For general administrative questions please refer to the original FEDBIZOPPS announcement for BAA03-02 of December 16, 2002.
- Record
- SN00279091-W 20030315/030313214021 (fbodaily.com)
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