SOLICITATION NOTICE
A -- Basic and Applied Research in Undersea Medicine
- Notice Date
- 3/5/2003
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of the Navy, Office of Naval Research, ONR, CODE ONR-02 800 N. QUINCY ST. Rm 704, Arlington, VA, 22217
- ZIP Code
- 22217
- Solicitation Number
- 03-002
- Archive Date
- 7/8/2003
- Point of Contact
- Steve Ahlers, Program Officer, Phone 703-696-0367, - Brian Kehoe, Contract Specialist, Phone (703) 696-2605,
- E-Mail Address
-
ahlerss@onr.navy.mil, kehoeb@onr.navy.mil
- Description
- The Office of Naval Research (ONR 341) is soliciting pre-proposals and proposals in the following topic area within the Medical Discovery and Invention program. This program includes basic research and applied research components. Undersea Medicine. The goal of this area is to elucidate the physiological and biochemical mechanisms that underlie the effects of stressors experienced by Navy and Marine Corps divers and Navy submarine personnel. Research proposals in the following areas are requested: 1) studies into the pathophysiology of decompression sickness (DCS) and arterial gas embolism (AGE) with an emphasis on characterizing a) immune system interactions with nitrogen gas emboli, b) how the immune system influences DCS/AGE risk, c) methods to improve prediction and diagnosis of DCS/AGE using non-invasive imaging techniques and predictive biochemical markers, d) improved therapeutic (non-recompressive) interventions to mitigate DCS and AGE, e) novel methods to remove excess nitrogen from biological tissues and f) greater understanding of how exposure to thermal stress can influence DCS risk; 2) studies to elucidate the pathology of hyperbaric oxygen toxicity (HBO) to include: a) biochemical mechanisms which sense molecular oxygen and reactive oxygen species, b) the biochemical and/or pathophysiological consequences of exposure to molecular oxygen and reactive oxygen species which result from exposure to hyperbaric oxygen, c) studies to develop prophylactic therapeutics for central nervous system and pulmonary HBO toxicity and d) methods to detect in real time the development of oxidative injury in situ; 3) studies to elucidate the basic physiological mechanisms which underlie high pressure nervous syndrome (HPNS) as well as the assessment of novel compounds to protect against HPNS; 4) studies to elucidate the acute effects of heat and cold stress on performance as well as the physiological adaptive mechanisms to heat and cold stress for improving divers' ability to operate in thermal extremes; 5) the effects of high and low frequency sound on human divers; and 6) the identification and mitigation of operational stressors experienced by submariners including technologies to improve operator performance in submarines in the littoral battle space and to improve the survival of submariners during submarine rescue operations. The technical POC for this component is CAPT(select) Stephen Ahlers, 703-696-0367, E-mail: ahlerss@onr.navy.mil. It is not the intent of this solicitation to establish new facilities; investigators should be able to demonstrate the required research capability and the necessary facilities. Pre-proposals and proposals whose main objectives are to conduct analyses, literature reviews, or program evaluations are not encouraged. A copy of the full BAA Announcement is located at www.onr.navy.mil/02/baa/
- Record
- SN00271295-W 20030307/030305213852 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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