SOLICITATION NOTICE
A -- ESTABLISHMENT OF A RESEARCH RESOURCE FOR THE IDENTIFICATION OF GENETIC AND ENVIRONMENTAL FACTORS INVOLVED IN THE DEVELOPMENT OF ANENCEPHALY
- Notice Date
- 11/27/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Research Contracts Branch, DERT P.O. Box 12874, 79 T.W. Alexander Dr, Bldg 4401, RTP, NC, 27709
- ZIP Code
- 27709
- Solicitation Number
- NIH-ES-03-04
- Response Due
- 2/26/2003
- Point of Contact
- Velvet Torain, Contract Specialist, Phone 919-541-0400, Fax 919-541-2712, - Juanita Clement, Contract Specialist, Phone 919-541-7893, Fax 919-541-2712,
- E-Mail Address
-
torain@niehs.nih.gov, clement1@niehs.nih.gov
- Small Business Set-Aside
- Total Small Business
- Description
- THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS), NATIONAL INSTITUTES OF HEALTH, INTENDS TO SOLICIT PROPOSALS FOR THE PURPOSE OF ESTABLISHING A RESEARCH RESOURCE TO IDENTIFY FACTORS THAT INDEPENDENTLY OR THROUGH INTERACTION(S) WITH GENETIC FACTORS, FOSTER THE DEVELOPMENT OF ANENCEPHALY. ANENCEPHALY, IS A NEURULATION CRANIAL DEFECT IN WHICH THE SKULL BONES, FOREBRAIN, AND CEREBRUM ARE PARTIALLY OR TOTALLY ABSENT. PART 1 OF THE PROJECT, THE DESIGN AND PLANNING PHASE, WILL TAKE APPROXIMATELY ONE YEAR TO COMPLETE. PART 2 OF THE PROJECT, THE RECRUITMENT PHASE, WILL TAKE APPROXIMATELY FOUR YEARS TO COMPLETE. THE MAJOR TASKS IN THIS STUDY ARE TO: (1) RECRUIT UP TO 500 FAMILY TRIADS AT A RATE OF 125 FAMILY TRIADS PER YEAR (FATHER, MOTHER, BABY) IN WHICH THE MOTHER IS CARRYING OR HAS HAD AN ANENCEPHALIC BABY (ONLY FETAL CADAVERIC TISSUE OBTAINED FOLLOWING AN ELECTIVE ABORTION, FROM A STILLBORN BABY OR AFTER THE BABY DIES IF LIVEBORN, WILL BE USED IN THIS STUDY); (2) COLLECT FRESH TISSUE FROM THE ANENCEPHALIC FETUSES AND USE THIS TO ISOLATE DNA AND, IF POSSIBLE, TO ESTABLISH CELL LINES; (3) COLLECT BLOOD FROM THE PARENTS, AND IF AVAILABLE ALSO FROM THE SIBLINGS, AND ISOLATE DNA, PLASMA AND SERUM FROM THE BLOOD; (4) MEASURE RBC FOLATE LEVELS IN THE MOTHER'S BLOOD; (5) CREATE AND ADMINISTER A COMPREHENSIVE QUESTIONNAIRE TO COLLECT EPIDEMIOLOGICAL DATA FROM THE PARENTS; (6) ENTER SAMPLE TRACKING AND OTHER DATA INTO A CENTRAL DATABASE USING THE INTERNET, AND (7) AFTER ISOLATING DNA AND ESTABLISHING CELL LINES FROM THE TRIADS' BLOOD AND TISSUES, THE CONTRACTOR(S) WILL ALIQUOT AND FREEZE ALL DNA, PLASMA AND SERUM ALIQUOTS, AND CELL LINES, AND SHIP THESE TO THE NIEHS OR A DESIGNATED ARCHIVE. THESE SAMPLES WILL AT A LATER DATE BE ASSAYED FOR GENETIC POLYMORPHISMS AND LEVELS OF POTENTIAL TOXICANTS ASSOCIATED WITH INCREASED RISKS FOR ANENCEPHALY. (THE FETAL TISSUE COLLECTED UNDER THIS CONTRACT WILL NOT BE USED FOR THE DERIVATION OF HUMAN EMBRYONIC STEM CELLS OR TRANSPLANTATION STUDIES, AND THEREFORE, DOES NOT FALL UNDER THE NATIONAL INSTITUTES OF HEALTH GUIDELINES FOR RESEARCH USING HUMAN PLURIPOTENT STEM CELLS (DHHS CODE OF FEDERAL REGULATIONS, 65 CFR 69951, EFFECTIVE AUGUST 25, 2000). THE ESTIMATED PERIOD OF PERFORMANCE IS FIVE YEARS. THE GOVERNMENT ESTIMATES THAT APPROXIMATELY 29,640 DIRECT LABOR HOURS MAY BE REQUIRED TO COMPLETE THIS PROJECT. THIS ACQUISITION IS 100% SET ASIDE FOR SMALL BUSINESS CONCERNS, FOR WHICH THE SIZE STANDARD IS 500 EMPLOYEES. THE NAICS CODE IS 541710. THE ANTICIPATED RELEASE DATE OF THE RFP IS JANUARY 8, 2003 WITH PROPOSALS DUE BY FEBRUARY 26, 2003. INTERESTED ORGANIZATIONS SHOULD REQUEST EITHER A STREAMLINED OR FULL RFP PACKAGE. IF NO SELECTION IS MADE A STREAMLINED VERSION OF THE RFP WILL BE PROVIDED, WHICH WILL INCLUDE ONLY THE STATEMENT OF WORK, DELIVERABLES AND REPORTING REQUIREMENTS, SPECIAL REQUIREMENTS, MANDATORY QUALIFICATION, AND TECHNICAL EVALUATION CRITERIA. REQUESTS MAY BE TELEFAXED, OR E-MAILED TO THE POINTS OF CONTACT LISTED BELOW. ELECTRONIC COPIES OF THE CBD SYNOPSIS AND RFP WILL BE MADE AVAILABLE ON THE INTERNET AT HTTP://WWW.NIEHS.NIH.GOV/DERT/RCB/RFP.HTM ON OR ABOUT JANUARY 8, 2003. GOVERNMENT-WIDE NUMBERED NOTES 1, 22, 26. NOTE: THIS NOTICE WAS NOT POSTED TO FEDBIZOPPS.GOV ON THE DATE INDICATED IN THE NOTICE ITSELF (27-NOV-2002). IT ACTUALLY FIRST APPEARED ON THE FEDBIZOPPS SYSTEM ON 18-JUN-2003. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Web Link
-
Link to FedBizOpps document.
(http://www.eps.gov/spg/HHS/NIH/NIEHS/NIH-ES-03-04/listing.html)
- Record
- SN00351069-F 20030620/030618214235 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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