SOLICITATION NOTICE
A -- Research and Development
- Notice Date
- 7/16/2003
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 427 Room 12, Frederick, MD, 21702
- ZIP Code
- 21702
- Solicitation Number
- IT5137
- Response Due
- 7/31/2003
- Archive Date
- 8/15/2003
- Point of Contact
- Lori Brooks, Secretary II, Phone (301) 846 - 1718, Fax (301) 846 - 5414,
- E-Mail Address
-
lbrooks@mail.ncifcrf.gov
- Description
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts, Building 1050, Frederick, MD 21702 Point of Contract Jeanne Lewis, Sr. Contract Specialist, (301) 644-2043; jlewis@ncifcrf.gov A?MULTIPLE AWARD, INDEFINITE DELIVERY, INDEFINITE QUANTITY RESEARCH AND DEVELOPMENT SUBCONTRACT FOR GENERATION OF HUMAN AND MOUSE CLONES MISSING FROM THE MGC COLLECTION OR FULL-INSERT CDNA SEQUENCING The NCIFCRF will be soliciting proposals for a multiple-award, 5 year contract. The RFP is expected to be issued on or about 08/11/03. The National Institutes of Health has established the Mammalian Gene Collection (MGC) program to obtain one representative full-open reading frame (ORF) clone and its complete sequence for every human and mouse gene. The MGC recently has also established partnerships with the rat, zebrafish and Xenopus communities to generate full ORF clone collections for those organisms. The MGC program is a multi-Institute effort that is building a publicly accessible resource of sequences and clones, along with associated informatics tools. This effort has already generated more than 1.4 million clones, of which approximately 50,000 have been fully sequenced, and nearly 20,000 human and mouse genes are currently represented in the collection. (For the most current numbers, see http://mgc.nci.nih.gov). This clone collection is used by scientists worldwide to enable biomedical research. The project has used an EST based strategy to identify putative full ORF clones. This approach has been quite productive, but there are many genes for which full ORF clones have not been identified yet. While the MGC will continue to use this strategy, it is anticipated that the most cost-effective approach to completing this collection will be one that is targeted to these missing genes. The MGC is open to different cost effective and efficient strategies to achieve this goal, including, for example, PCR cloning directly from RNA or cDNA library sources or clone synthesis. The acquisition of pre-existing sets of full-ORF clones to be incorporated into the MGC clone collection could also contribute to meeting the project?s goals. At the same time, the existing random EST strategy will continue to be employed for the rat, zebrafish and Xenopus gene collection projects since this approach is effective for the scale of the projects being undertaken. To accomplish all of these goals, the MGC will also need to support high quality full-insert cDNA sequencing activities. Organizations interested in participating in the either the generation of human and mouse clones missing from the MGC collection or full-insert cDNA sequencing are requested to send or e-mail letters of interest to the address contained herein. Multiple multi-year awards are anticipated. The production of supplies listed may require a substantial investment. Place of performance will be the awardees locations.
- Record
- SN00372652-W 20030718/030716213335 (fbodaily.com)
- Source
-
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