SOURCES SOUGHT
A -- Molecular Libraries Small Molecule Repository
- Notice Date
- 10/3/2003
- Notice Type
- Sources Sought
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Mental Health, Contracts Management Branch 6001 Executive Blvd, Rm 8154, MSC 9661, Bethesda, MD, 20892-9661
- ZIP Code
- 20892-9661
- Solicitation Number
- Reference-Number-DNBBS-SS-04-01
- Response Due
- 10/24/2003
- Archive Date
- 11/7/2003
- Point of Contact
- Bruce Anderson, Contracting Officer, Phone 301-443-2234, Fax 301-443-0501,
- E-Mail Address
-
ba9i@nih.gov
- Description
- Molecular Libraries Small Molecule Repository The National Institute of Mental Health is conducting a market survey to assess the availability and technical capability of all types of organizations, to provide the scientific and technical expertise necessary to establish the Molecular Libraries Small Molecule Repository, described below. This announcement is intended to conduct market research to establish: 1) whether small businesses are capable of performing this effort (as defined by NAICS Code 541710 - Research and Development in the Physical, Engineering and Life Sciences); and 2) whether there is sufficient capability and interest from all types of organizations and businesses to conduct an efficient competition. Capability statements should include a concise summary of specific capabilities to perform this work by addressing the following: (1) professional qualifications and experience of specific personnel in providing these services; (2) the organization's specific experience related to this work; (3) the type of organization (e.g. small business [state NAICS Codes], nonprofit etc.). This is not a Request for Proposals (RFP). Please provide three (3) copies of your capability statement by October 24, 2003. These statements should not be unnecessarily lengthy or elaborate. Point of Contact: Bruce E. Anderson, Contracting Officer, Phone (301) 443-2234, Fax (301) 443-0501, Email: ba9i@nih.gov The Small Molecule Repository is a component of the National Institutes of Health (NIH) Roadmap Molecular Libraries initiative for the creation of an NIH small molecule library and screening centers (for additional information on the NIH Roadmap, see http://nihroadmap.nih.gov/). It is anticipated that the Small Molecule Repository will be accomplished through a contract mechanism (a 5-10 year contract). The Small Molecule Repository will offer public sector biomedical researchers access to small organic molecules that can be used as chemical probes to study cellular pathways in greater depth and will provide new ways to explore the functions of major components of the cell in health and disease. In order to provide these benefits, the library of small molecules must contain a sufficient number of diverse compounds to be screened for a large number of possible new activities and applications. To build such a library, a contract will be established to acquire, maintain, and distribute a collection of approximately 500,000 chemically diverse small molecules of both known and unknown activities. An NIH Molecular Libraries Steering Committee will help identify candidate compounds to be acquired from government, academic, industry and commercial sources. Over time, this collection will be expanded and modified to include compounds that are capable of interacting with an increasing number and diversity of biomolecular target domains. The development of such libraries will provide probes for studying molecular events, pathways, and networks in biologic systems that span the scale from single cells to whole organisms. Anticipated requirements for the Molecular Libraries Small Molecule Repository include the following tasks: 1) Compound Identification and Library Development. The contractor, in coordination with a NIH Molecular Libraries Steering Committee, shall identify candidate compounds from government, academic, industry and commercial sources, and acquire a collection of approximately 500,000 compounds meeting criteria to be specified by the Government Project Officer (GPO)/Steering Committee (i.e., stability, solubility, availability of sufficient quantities, ease of re-supply or re-synthesis, diversity). Initially the contract will focus primarily on this task. Over the course of the contract, this function will continue but the effort will decrease as the library develops in size. 2) Handling, Plating and Distribution. All compounds shall be bar-coded and arrayed in sets suitable for supplying to high-throughput screening (HTS) facilities. The contractor shall have the capability to array compounds into both 96 and 384 well plates to produce arrays in a format suitable for long term storage and shall have the ability to produce arrays for distribution (i.e. daughter-plates developed from plate replication or reformatting into higher density 1536 or 3456 well plates). Compound arrays shall be distributed to the Molecular Library Screening Centers and other interested HTS facilities. The contractor shall also provide arrays of compounds to investigators on a fee for service basis. 3) Storage. Compounds shall be stored in arrayed sets under conditions that ensure optimal stability and purity. The contractor shall provide the necessary expertise, equipment, and facilities to store, maintain, and track the compound collection inventory. The contractor shall propose a plan to monitor the stability of compounds in the library (e.g., analysis by LC/MS, HPLC, and/or NMR). 4) Re-supply and Re-synthesis. The contractor shall monitor the compound inventory to ensure that sufficient quantities of all compounds (minimum of 1mg) are available to support screening needs. As compounds become depleted the Contractor shall purchase sufficient quantities of the compound to replenish the inventory. The Contractor shall have the ability to synthesize, at a minimum purity of 90%, sufficient quantities of depleted compounds that cannot be re-purchased. 5) Informatics. The Contractor shall provide the necessary informatics support to track compound inventory and distribution, including maintenance of a compound collection inventory database and shipping and distribution databases for each screening center and for extramural requests. The contractor shall create and maintain a repository website, describing the program and providing a list of available arrays. The contractor shall also provide the capability of interfacing any repository informatics systems with other Molecular Libraries databases. 6) Confidentiality. The contractor may be acquiring and handling some proprietary compounds under this contract. To protect the preexisting rights of these compound suppliers the NIMH may exercise its authority under FAR 27.303 in seeking a deviation for this contract from the standard patent rights clause, FAR 52.227-11, Patent Rights - Retention by the Contractor (Short Form) (June 1997); if approved, this deviated clause would restrict the Contractor's rights in subject inventions involving proprietary compounds. The NIMH will publicize this clause in full text, and seek public comments, at a later date.
- Record
- SN00447362-W 20031005/031003213051 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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