SOLICITATION NOTICE
A -- Preclinical Pharmacological Studies of Antitumor and Other Therapeutic Agents
- Notice Date
- 1/16/2004
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- N01-CM-47015-45
- Archive Date
- 12/31/2004
- Point of Contact
- Kathy Giuliano, Contract Specialist, Phone (301) 435-3821, Fax (301) 402-6699, - MaryAnne Golling, Contracting Officer, Phone (301) 435-3819, Fax (301) 402-6699,
- E-Mail Address
-
kg109o@nih.gov, mg345x@nih.gov
- Description
- The Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD) National Cancer Institute (NCI) of the National Institute of Health (NIH) is soliciting organizations having the necessary experience, scientific and technical personnel and facilities to conduct a series of preclinical pharmacokinetic and other pharmacology studies in animals on agents having demonstrated antitumor or other therapeutic activity and considered by DCTD to merit further development. The studies to be performed will include: the development of methodology for the quantitative measurement of test agents and/or metabolites in body fluids and tissues; stability studies of test agents in biological fluids; plasma protein binding determinations; characterization of in vivo plasma concentration-time profiles and calculation of relevant pharmacokinetic parameters; determination of test agent levels in samples provided by other DTP contractors; determination of the most effective mode of agent administration to achieve and maintain effective concentrations in body fluids and tissues; bioavailability studies following administration of an agent by various routes; tissue distribution and urinary excretion studies; structural determination of metabolites and/or degradation products of parent agents produced in animals and in model in vitro systems (e.g., animal and/or human liver slices, hepatocytes, S9 fractions, and microsomal preparations). Where appropriate, this information will be correlated with pharmacodynamic or biomarker data obtained in studies with drug-treated animals. To the extent possible, the Government will supply study animals (e.g.,mice, rats, dogs, non-human primates), test agents, and radiolabeled test agents. Contractors will be expected to provide all equipment, solvents, reagents and animal facilities needed to conduct this type of work. AAALAC accreditation is highly desirable. It is anticipated that five or six awards will be made as a result of the Request for Proposal (RFP), each for a five-year, incrementally-funded completion type contract with two additional option years. Only one award will be made to an institution. The following Mandatory Qualification Criteria will apply: (1) the Contractor may not be a pharmaceutical or chemical firm since agents of a commercially confidential nature (discreet) may be evaluated; (2) the Contractor must possess a valid NRC license permitting the purchase, storage and use of typical quantities of radioisotopes (e.g., 3H, 14C, 35S) likely to be used in the proposed pharmacological research. NAICS Code No. 541710 with a size standard of 500 employees. The solicitation is scheduled for electronic release on or about February 11, 2004. The RFP may be accessed through internet address http://rcb.nci.nih.gov/, It is the offeror?s responsibility to monitor the internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFEROR?S WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. Point of contact: Kathleen Giuliano, Contract Specialist at e-mail: giuliank@mail.nih.gov/ Fax: 301-402-6699; Telephone: 301-435-3821. No collect calls will be accepted.
- Record
- SN00505245-W 20040118/040116211810 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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