SOLICITATION NOTICE
A -- Longitudinal Study of the Estrogen and Progesterone Effects on Biomarkers of Oxidative Stress and Antioxidant Status During the Menstrual Cycle
- Notice Date
- 1/21/2004
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, MD, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- RFP-NICHD-2004-01
- Response Due
- 3/23/2004
- Archive Date
- 6/30/2004
- Point of Contact
- Robert Stallings, Contract Specialist, Phone 301-435-6965, Fax 301-402-3676, - Paul Duska, Contracting Officer, Phone 301-435-6955, Fax 301-402-3676,
- E-Mail Address
-
bs79d@nih.gov, pd28n@nih.gov
- Description
- The Division of Epidemiology, Statistics and Prevention, National Institute of Child Health and Human Development (DESPR/NICHD) is planning to award a contract for a program entitled, ?LONGITUDINAL STUDY OF THE ESTROGEN AND PROGESTERONE EFFECTS ON BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS DURING THE MENSTRUAL CYCLE.? The NICHD seeks a contractor capable of establishing a longitudinal cohort study to determine the pre-menopausal cyclic relationship between oxidative stress biomarkers and hormonal fluctuations in order to analyze their effect on women?s reproductive health and disease. Recent animal and human studies suggest that oxidative stress might be implicated in the risk of female infertility through associations with follicular growth, the development of endometriosis, and regulation of angiogenesis in the endometrium, but the mechanisms are not completely understood. Although it is known that micronutrient antioxidants, hormones, and enzymatic antioxidants are able to neutralize oxygen free radicals and inhibit oxidation, the use of these therapies to reduce the risk of infertility has been limited by a lack of basic understanding. THE OBJECTIVES OF THIS PROJECT ARE: (i) to study the intra-cycle variation of oxidative stress during menstruation; (ii) to determine the relationship between sex-hormones and oxidative stress during the menstrual cycle in pre-menopausal women; (iii) to examine the influence of external factors such as over-the-counter medications, cigarette smoking, alcohol consumption, and exercise on oxidative stress and hormone levels; and (iv) to evaluate the validity and reliability of biomarkers of oxidative stress and antioxidant status in blood and urine. To meet these objectives, a prospective longitudinal cohort study is being designed. An estimated total of approximately 260 pre-menopausal, healthy (chlamydia-free) women will be required to participate in this study. To receive consideration for a contract award, an offeror must be able to: 1) Demonstrate a clear understanding of menstrual function and its relation to oxidative stress, including the potential role of environmental factors, biological variability and laboratory measurements; 2) Provide evidence of a solid understanding regarding the utility and feasibility of a longitudinal design for empirically assessing the relation between biomarkers of oxidative stress, lifestyle factors and human reproduction and development; and, 3) Provide evidence of an ability to: a) identify, recruit and retain participants; b) collect longitudinal data and biologic specimens using quality assurance procedures (include information on what quality assurance procedures have been/will be used); and c) establish and comply with a study protocol in collaboration with the NICHD. The required service is defined as code 541990 under the North American Industry Classification System (NAICS). The Request for Proposal (RFP) will be available on or before January 23, 2004 through the web site at http://FedBizOpps.gov . All responses must be submitted on or before March 23, 2004, to: Robert Stallings, Contract Specialist, NICHD, CMB, 6100 Building, Suite 7A07, 6100 EXECUTIVE BLVD MSC 7510, BETHESDA MD 20892-7510 (if sending by overnight carrier, use 6100 Executive Blvd., Suite 7A07, Rockville, MD 20852). Questions may be directed to: Robert Stallings, Contract Specialist, by telephone (301) 435-6965; FAX 301-402-3676; or e-mail bs79d@nih.gov. Fully electronic copies will not be accepted, but portions of the proposal may be provided on disc. The reference number to be used for this announcement is: RFP NICHD-2004-01. All correspondence must cite the reference number as provided. The resultant contract is anticipated to have duration of two years.
- Record
- SN00507222-W 20040123/040121211904 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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