MODIFICATION
A -- Defense Sciences Research and Technology
- Notice Date
- 10/22/2003
- Notice Type
- Modification
- Contracting Office
- Other Defense Agencies, Defense Advanced Research Projects Agency, Contracts Management Office, 3701 North Fairfax Drive, Arlington, VA, 22203-1714
- ZIP Code
- 22203-1714
- Solicitation Number
- BAA03-02
- Response Due
- 1/16/2004
- Point of Contact
- Steven Wax, Deputy Director, Defense Sciences Office, Phone 703-696-2281, Fax 571-218-4553,
- E-Mail Address
-
none
- Description
- METABOLIC DOMINANCE, BAA 03-02, Addendum 2, DUE 041703, POC: DR. JOSEPH T. BIELITZKI, DARPA/DSO, Fax: (571) 218-4553, Email: baa03-02@darpa.mil, URL: www.darpa.mil/baa/#dso. PROGRAM GOALS AND OBJECTIVES: The Defense Sciences Office is interested in proposals to develop innovative science and technology capable of affording superior physiological qualities to the warfighter. The vision for the Metabolic Dominance Program is to develop novel strategies that exploit and control the mechanisms of energy production, metabolism, and utilization during short periods of deployment requiring unprecedented levels of physical demand. The ultimate goal is to enable superior physical and physiological performance by controlling energy metabolism on demand. An example is continuous peak physical performance and cognitive function for 3 to 5 days, 24 hours per day, without the need for calories. Continuous exertion over numerous days is currently limited by: 1) the ability to transport and ingest adequate calories and/or effectively access stored calories (e.g., adipose, glycogen); 2) available training time; extended training periods are required to adapt muscle and mitochondria to meet intense physical loads; and 3) the ability of physiological systems to rapidly recover after extended, repeated bouts of physical exertion. Metabolic Dominance (MD) is a two phase program. Phase 1 will establish proof-of-concept for four integrated areas of emphasis that together address methods for enhancing soldier performance. These areas of emphasis focus on: 1) optimizing metabolic performance by developing an understanding of how to control substrate availability and remove metabolic waste products; 2) controlling the thermal environment where energy metabolism occurs; 3) regulating the number and efficiency of cells and organelles necessary for energy production; and 4) identifying the cause of fatigue and, thus, short- or long-term performance degradation. Phase 2 will provide specific expanded deliverables based on the successful completion of Phase 1. Proposals responding to this BAA should describe an 18-month Phase 1 effort focused on one or more of the areas of emphasis described below. Although Phase 2 proposals will be requested at a later date, proposers should clearly indicate what their Phase 2 goals would be and how their 18-month milestones in Phase 1 would lead to the success of those goals. Phase I proposals should address one or more of the following areas of emphasis: 1) METABOLIC OPTIMIZATION: The warfighter cannot consume adequate calories to sustain metabolic needs over short, intense periods of deployment. This area seeks concepts for increasing substrate availability to tissues important for strength and endurance, including, but not limited to, proposals investigating: a) methods and mechanisms for rapidly inducing a switch from carbohydrate metabolism to lipolysis as a sustainable source of cellular energy; b) the development of an idealized and customized program for nutritionally preloading the warfighter to facilitate the metabolic transition to lipolysis, c) the development of nutriceuticals or natural products that provide demonstrable benefit for maintaining strength and endurance; d) methods and mechanisms to increase oxygen and metabolite availability to selected tissues, to increase the rate and/or the efficiency of energy metabolism, and/or to provide supplemental high energy phosphates to targeted populations of cells; e) methods and mechanisms to remove or control accumulated metabolic byproducts and/or reactive oxygen species. A key 18-month milestone for the MD Program is demonstration of the ability to selectively regulate the metabolic source of calories on demand, that is, the ability to control the switch from carbohydrate to lipid metabolism, and reverse, for energy production. Key milestones for the end of Phase 2 include the ability to selectively regulate the metabolic energy source; as well NOTE: THIS NOTICE WAS NOT POSTED TO FEDBIZOPPS.GOV ON THE DATE INDICATED IN THE NOTICE ITSELF (22-OCT-2003). IT ACTUALLY APPEARED OR REAPPEARED ON THE FEDBIZOPPS SYSTEM ON 30-JAN-2004. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Web Link
-
Link to FedBizOpps document.
(http://www.eps.gov/spg/ODA/DARPA/CMO/BAA03-02/listing.html)
- Record
- SN00513570-F 20040201/040130215215 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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