SOLICITATION NOTICE
A -- Chronic Microelectrode Recording Arrays
- Notice Date
- 2/24/2004
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke, 6001 Executive Boulevard, Neuroscience Center, Suite 3287, MSC 9531, Bethesda, MD, 20892-9531
- ZIP Code
- 20892-9531
- Solicitation Number
- NIH-NINDS-04-04
- Response Due
- 5/11/2004
- Archive Date
- 5/26/2004
- Point of Contact
- Laurie Leonard, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, - Ida Lirette, Program Specialist, Phone 301 496-1813, Fax 301 402-4225,
- E-Mail Address
-
ll44s@nih.gov, il26v@nih.gov
- Description
- The National Institute of Neurological Disorders and Stroke (NINDS) is considering to support the development and delivery of a complete recording system that is safe, efficient, and reliable for chronic implant applications, as demonstrated and validated by both in vitro and long-term in vivo testing. In past research and development, multiple microelectrode recording sites have been fabricated on shanks as small as 60 microns wide and 15 microns thick. Amplifiers integrated into the silicon microelectrodes have successfully amplified and buffered signals from single and multiple unit extracellular neural activities. Additional electronic circuitry that provides selection of multiple recording channels and multiplexing of signals from multiple recording sites has also been integrated into the array. Acute recordings have demonstrated the functionality of this multiplexed system. After three months implantation in guinea pig auditory cortex, excellent biocompatibility of these microeletrodes has been demonstrated with healthy appearing neurons within 10 microns of the microelectrode recording site. A series of polymide cables have been fabricated allowing high-density two-dimensional interconnections to active recording probes in vivo. In moving towards the long-term goal of developing an integrated microelectrode system that permits recording of extracellular neural activity from many neurons over decades of use in humans, this research and development project will build on previous results with an emphasis on chronic implant applications. In addition to the microelectrode array, the implantable system consists of a cable system to provide a signal and power path between the microelectrode array and the external world, and a telemetry system for transmission of the signals from an implanted array to an extracorporal receiver. The cable system will be designed to be compatible with human implantation and must not transmit mechanical force to the microelectrode array that would cause it to be displaced in the neural tissue. An interface circuitry will be designed to provide on-chip amplification, filtering, time-division multiplexing, and in vivo real-time signal processing. Although no human studies are required at this stage, the system should be tested rigorously both in vitro and in vivo, especially on chronic non-human primates with a goal of eventually developing a system capable of providing chronic neural recordings from human cortex. The overall objective of this research and development project is to design and fabricate a chronic microelectrode array for recording of neural activity from many neurons over decades for use in humans. The array will have an integrated cable and telemetry system that permits signals collected from these microelectrode arrays to be sent reliably out of the body. Such an integrated system will include an electrical cable, in vivo signal processing circuitry and a telemetry unit. The system will be tested in vitro and in chronic behaving primates. The focus will be on the reliability of the system in recording quality signals over a period of 6-12 months, and on its safety and effectiveness in general design. No human studies will be required. Personnel with established expertise in micromachining, bioengineering, integrated circuit design, integrated circuit fabrication, and animal studies will be needed to perform this research. It is anticipated that one cost-reimbursement type contract will be made for a period of four (4) years in September 2004. This is not a Request for Proposals (RFP). THIS SOLICITATION WILL BE AVAILABLE ELECTRONICALLY ONLY. Request for Proposal (RFP) No. NIH-NINDS-04-04 will be available electronically and may be accessed through the FedBizOpps (URL: http://www.fedbizopps.gov) or through the NINDS website at the following URL address: (http://www.ninds.nih.gov/funding/currentrfps.htm) 15 or more calendar days after the issuance of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. All responsible sources may submit a proposal, which shall be considered by the agency. Refer to number note 26. ****
- Record
- SN00529343-W 20040226/040225082516 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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