Loren Data's SAM Daily™

fbodaily.com
Home Today's SAM Search Archives Numbered Notes CBD Archives Subscribe
FBO DAILY ISSUE OF APRIL 02, 2004 FBO #0858
MODIFICATION

A -- Defense Sciences Research and Technology

Notice Date
3/31/2004
 
Notice Type
Modification
 
NAICS
541710 — Research and Development in the Physical, Engineering, and Life Sciences
 
Contracting Office
Other Defense Agencies, Defense Advanced Research Projects Agency, Contracts Management Office, 3701 North Fairfax Drive, Arlington, VA, 22203-1714
 
ZIP Code
22203-1714
 
Solicitation Number
BAA04-12
 
Response Due
2/2/2005
 
Archive Date
2/3/2005
 
Point of Contact
Brett Giroir, Deputy Director, DSO, Phone (571) 218-4224, Fax (571) 218-4553,
 
E-Mail Address
bgiroir@darpa.mil
 
Description
SURVIVING BLOOD LOSS, SOL BAA04-12, Addendum 3, DUE 062104, POC: DR. JOSEPH BIELITZKI, DARPA/DSO, Ph: (703) 696-5278,. Email: baa04-12@darpa.mil, URL: www.darpa.mil/dso. Website Submission: http://www.sainc.com/dso0412/. The Defense Sciences Office is interested in innovative proposals to develop the science and technology necessary to reduce fatalities associated with traumatic injury and blood loss. The vision for the Surviving Blood Loss (SBL) Program is to develop novel strategies that delay the onset of irreversible shock and allow an injured warfighter to survive with significantly reduced oxygen delivery for extended periods of time, thus providing increased time for evacuation, triage, and initiation of supportive therapies. This will be an extremely aggressive, milestone driven program with a (24 month) Phase 1 effort that will culminate in the demonstration of at least 75% survival in a rodent model of controlled hemorrhagic shock, in which 60% of the estimated blood volume is removed and the animal is maintained for 3 hours prior to crystalloid resuscitation. Based on the successful completion of Phase 1, the Phase 2 program will demonstrate 75% survival after 6 hours of hemorrhagic shock (as described above), as well as the demonstration of equivalent effects in a second experimental model. To accomplish this Phase 1 effort, it is expected that interdisciplinary teams will be required to develop an understanding of the control mechanisms of energy production, metabolism, and oxygen utilization and then identify and control the protective mechanisms that preserve cellular function despite critically depressed oxygen delivery. Specific technical challenges may include: 1) understanding how cellular metabolism can be modified to match oxygen and substrate supply; 2) determining whether alternative electron acceptors may be used to prevent oxidative damage; 3) determining whether metabolic states may be switched on demand; 4) elucidating the physiological mechanisms in naturally occurring animal models of hypometabolic states 4) identifying protective preconditioning strategies; 5) clarifying the basis of evolutionary adaptations in species that survive temporary adverse environments through metabolic control (e.g., cold, oxygen depletion, famine, estavation/hibernation, diving); 6) providing rapid, complete restoration of normal physiological activity following an induced systemic metabolic stasis; and/or 7) showing that these mechanisms may be applied to humans at the level of the organ and/or organism in order to develop an integrated approach to improve stability following injury and/or blood loss. Proposals responding to this BAA should describe a 24-month Phase 1 effort focused on achieving a Phase 1 milestone described above. It is suggested that teams be proposed that can address the technical challenges described above and integrate them into a single proposal. Consideration will be given to proposals that attack one or more of those challenges in the absence of an integrated team provided they are willing to be integrated with another team that has accepted the challenge of meeting the specific milestone. Phase 2 proposals will be requested at a later date. Proposers should clearly indicate how their Phase 1 deliverables and milestones will transition into Phase 2 activities. TEAMING. Progress in the SBL program will depend on the formation of well-managed interdisciplinary efforts that draw on expertise from such areas as metabolic physiology, energetics, nutrition, endocrinology, muscle physiology, mitochondrial physiology, hibernation, immunology, biochemistry, hemorrhagic shock, and cellular biology. In addition, it is expected that a strong mathematics and/or computer modeling component will be included where necessary. Members of interdisciplinary teams will be required to work collaboratively and collectively maintain sharp focus toward achieving the Phase 1 objectives. Submission of White Papers: We invite white papers (10 pages or less) in response to this announcement. The white paper should be organized as follows: 1) An Executive Summary. 2) The idea. Which area(s) of emphasis are you addressing? 3) The approach. How will you address these areas? Briefly define the research plan you intend to follow. What are the research challenges, and how will they be addressed? What is unique or revolutionary about your approach? What additional capabilities do you envision will be enabled by your ideas? How do you plan to demonstrate the success of the research effort within the 24-month period of funding? Every white paper must describe specific, quantitative milestone(s) that need to be achieved in order to demonstrate progress in reaching the ultimate goals of the program. 4) The cost. What is your cost estimate for resources required for the proposed time line? 5) The Management Plan. A brief description of the technical expertise of the principal investigator and the key team members must be provided, along with a management plan describing how different disciplines represented on the team will be integrated to ultimately generate a proof-of-concept to be completed within 24 months. White papers sent in response to this addendum are due at DARPA no later than 1600 hours ET, May 3, 2004. Proposers submitting white papers will be notified within 15 business days of that date if a full proposal will be requested. To facilitate the submission process, a website has been established, http://www.sainc.com/dso0412/. Not withstanding the disposition of white papers, DARPA will accept full proposals for this addendum. PROPOSAL REQUIREMENTS: Each proposal should: 1) explicitly address tests, demonstrations, and other research activities planned in the area(s) of interest described above, 2) include at least two specific and quantitative scientific and/or technical objectives for each scientific/technical area of interest addressed in the proposal that clearly demonstrate the research is on track for meeting the ultimate program goal, 3) include clearly delineated intellectual property arrangements and transition paths, and 4) include identification and assessment of critical scientific and/or technical barriers to the program objective and plausible approaches to develop solutions or overcome their limiting effects. Upon award, specific deliverables and appropriate level demonstrations of the science and/or technology elements will be required periodically, and a final demonstration of the deliverable system is required at the end of the program. Given the breadth of the areas of interest, it is anticipated that only comprehensive and fully integrated team efforts addressing the entire challenge problem will be funded and, therefore, bidder teaming is highly encouraged. Proposed Phase 1 efforts should not exceed 24 months, but consideration should be given to possible continuation of the effort into Phase 2. If proposals include use of Government facilities, offerors will be expected to conclude commercial services arrangements with the providing Government facility. If multiple awards are made, down-selection may occur annually based on technical progress and achievements. Proposals with cost share should clearly identify the specific tasks to be cost shared in the technical proposal and separately break out the corresponding costs in the cost proposal. The number of awards will be dependent on the suitability of proposals received and availability of funds. Full proposals shall consist of two volumes: technical and cost. The technical and cost volumes shall conform to the guidelines in DARPA (DSO) BAA 04-12 of February 2, 2004. To receive consideration under this addendum PROPOSALS ARE DUE AT DARPA NO LATER THAN 1600 ET JUNE 21, 2004, at the address shown below. Proposals received after that date, will be considered under the open BAA only. A website http://www.sainc.com/dso0412/ has been established to facilitate the submission of full proposals electronically. This site will allow the filling in of contact information and the uploading of a full proposal created with the requirements listed in this addendum and in accordance with the original BAA04-12 published. Note: if the website is not used, please use the U.S. mail system to the address listed below or the BAA e-mail account. EVALUATION OF PROPOSALS: Evaluation of the proposals will be in accordance with BAA04-12. For complete details on writing a full proposal, please see original FEDBIZOPS solicitation, BAA04-12, http://darpa.mil/dso/solicitations/solicit.htm. Address for Submission of Unclassified White Papers or Full Proposals: DARPA/DSO, ATTN: BAA04-12 Addendum 3, 3701 North Fairfax Drive, Arlington, VA 22203-1714. E-Mail: baa04-12@darpa.mil GENERAL INFORMATION: In all correspondence, reference BAA04-12, Addendum 3. Technical Point of Contact: Dr. Joseph Bielitzki, DARPA/DSO; Phone :( 703) 696-5278; Fax: (703) 741-0024, Email jbielitzki@darpa.mil. Original Point of Contact: Brett Giroir, Deputy Director, Defense Sciences Office, Phone (571) 218-4224, Fax (571) 218-4553, Email bgiroir@darpa.mil.
 
Record
SN00557777-W 20040402/040331212645 (fbodaily.com)
 
Source
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

FSG Index  |  This Issue's Index  |  Today's FBO Daily Index Page |
ECGrid: EDI VAN Interconnect ECGridOS: EDI Web Services Interconnect API Government Data Publications CBDDisk Subscribers
 Privacy Policy  Jenny in Wanderland!  © 1994-2024, Loren Data Corp.