MODIFICATION
A -- Establishment of a Research Resource for the Identification of Genetic and Environmental Factors Involved in the Development of Anencephaly
- Notice Date
- 8/28/2003
- Notice Type
- Modification
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Research Contracts Branch, DERT P.O. Box 12874, 79 T.W. Alexander Dr, Bldg 4401, RTP, NC, 27709
- ZIP Code
- 27709
- Solicitation Number
- NIH-ES-03-20
- Response Due
- 9/22/2003
- Point of Contact
- Velvet Torain, Contract Specialist, Phone 919-541-0400, Fax 919-541-2712,
- E-Mail Address
-
torain@niehs.nih.gov
- Description
- AMENDMENT 02. THE DUE DATE FOR RECEIPT OF PROPOSALS IS CHANGED TO SEPTEMBER 22, 2003 BY 4:00 pm LOCAL TIME. ALL OTHER ASPECTS OF THE REFERENCED SOLICIATION REMAIN THE SAME. THIS AMENDMENT MUST BE ACKNOWLEDGED. The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Intends to Solicit Proposals for the Purpose of Establishing a Research Resource to Identify Factors That Independently or Through Interaction(s) with Genetic Factors, Foster the Development of Anencephaly. Anencephaly, Is a Neurulation Cranial Defect in Which the Skull Bones, Forebrain, and Cerebrum (Thinking and Coordinating Area of the Brain) Are Partially or Totally Absent. Part 1 of the Project, the Design and Planning Phase, Will Take Approximately One Year to Complete. Part 2 of the Project, the Recruitment Phase, Will Take Approximately Four Years to Complete. The Major Tasks in this Study Are To: (1) Recruit up to 500 Families at a Rate of 125 Families per Year (Father, Mother, Baby, and Siblings If Available) in Which the Mother Is Carrying or Has Had an Anencephalic Baby (Only Fetal Cadaveric Tissue Obtained Following an Elective Abortion, from a Stillborn Baby or after the Baby Dies If Liveborn, Will Be Used in this Study); (2) Collect Fresh Tissue from the Anencephalic Fetuses and Use this to Isolate DNA And, If Possible, to Establish Cell Lines; (3) Collect Blood from the Parents, and If Available Also from the Siblings, and Isolate DNA, Plasma and Serum from the Blood; (4) Measure RBC Folate Levels in the Mother's Blood; (5) Create and Administer a Comprehensive Questionnaire to Collect Epidemiological Data from the Parents; and (6) Enter Sample Tracking and Other Data into a Central Database Using the Internet. After Isolating DNA and Establishing Cell Lines from the Families Blood and Tissues, the Contractor(s) Will Aliquot and Freeze All DNA, Plasma and Serum Aliquots, and Cell Lines, and Ship These to the NIEHS or a Designated Archive. These Samples Will Be Assayed for Genetic Polymorphisms and Levels of Potential Toxicants Associated with Increased Risks for Anencephaly. (The Fetal Tissue Collected under this Contract Will Not Be Used for the Drivation of Human Embryonic Stem Cells or Transplantation Studies, and Therefore, Does Not Fall under the National Institutes of Health Guidelines for Research Using Human Pluripotent Stem Cells (DHHS Code of Federal Regulations, 65 CFR 69951, Effective August 25, 2000). The Estimated Period of Performance Is Five Years. The Government Estimates That Approximately 29,640 Direct Labor Hours May Be Required to Complete this Project. The North American Industry Classification Code (NAICS) Is 541710. This Is a Full and Open Competition. The Anticipated Release Date of the RFP Is July 18 2003 with Proposals Due by September 8, 2003. Interested Organizations Should Request Either a Streamlined or Full RFP Package. If No Selection Is Made a Streamlined Version of the RFP Will Be Provided, Which Will Include Only the Statement of Work, Deliverables and Reporting Requirements, Special Requirements, Mandatory Qualification, and Technical Evaluation Criteria. Requests May Be Telefaxed, or E-mailed to the Points of Contact Listed Below. Electronic Copies of the Fed Bix Opps Synopsis and Rfp Will Be Made Available on the Internet at Http://www.niehs.nih.gov/dert/rcb/rfp.htm on or about July 25, 2003. GOVERNMENT-WIDE NUMBERD NOTE 26 NOTE: THIS NOTICE MAY HAVE POSTED ON WWW.FEDBIZOPPS.GOV ON THE DATE INDICATED IN THE NOTICE ITSELF (28-AUG-2003). IT ACTUALLY APPEARED OR REAPPEARED ON THE FEDBIZOPPS SYSTEM ON 03-NOV-2004, BUT REAPPEARED IN THE FTP FEED FOR THIS POSTING DATE. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Web Link
-
Link to FedBizOpps document.
(http://www.eps.gov/spg/HHS/NIH/NIEHS/NIH-ES-03-20/listing.html)
- Record
- SN00703590-F 20041105/041103213820 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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