Loren Data's SAM Daily™

FBO DAILY ISSUE OF MARCH 09, 2005 FBO #1199
SOURCES SOUGHT

A -- Woodchuck Evaluation of Candidate Hepatitis Therapies

Notice Date

3/7/2005
 

Notice Type

Sources Sought
 

NAICS

541710 — Research and Development in the Physical, Engineering, and Life Sciences
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Program 6700 B Rockledge Room 3214 MSC7612, Bethesda, MD, 20892-7612
 

ZIP Code

20892-7612
 

Solicitation Number

Reference-Number-DMID-05-36
 

Response Due

4/21/2005
 

Archive Date

4/21/2005
 

Description

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Department of Health and Human Services, intends to negotiate on a sole source basis with Cornell University (123 Day Hill Ithaca, NY) to continue performing woodchuck evaluations of candidate Hepatitis B therapies under the authority 41 U.S.C. 253(c) (1), as set forth in FAR 6.302-1. The contractor shall provide a continuous supply of native controls and woodchuck hepatitis virus (WHV) chronic carrier woodchucks for therapeutic evaluation. The Contractor will develop protocols for optimal in vivo testing. Animal protocols may include optimizing dose requirements, preparing samples for pharmacokinetic analysis, determining efficacy and safety of drugs/immunomodulators approved for screening, assessing drug-drug interactions with other therapeutic candidates, performing all relevant assays, and preparing final reports of study results to suppliers. Cornell, an experienced hepadnavirus drug evaluator, with an AAALAC-accredited colony of woodchucks will test NIAID assigned therapeutics for efficacy and safety against the diseases caused by hepatitis B infection. All woodchucks will be bred in the colony?not wild-caught?to prevent inadvertent complications by coinfections. Some of the newborn pups will be set aside for controls and for replenishing the breeding colony. Most new pups will be infected with a well-characterized pool of WHV and followed for the first six to nine months to determine if chronicity occurs. Chronic carriers will be used for assessing efficacy, safety, optimal dose, and pharmacology. The Contractor will work with the NIAID staff and reagent sponsors to prepare optimal protocols, perform the experimental studies including assaying samples and analyzing results, and generate a final report. The Principle Investigator and contract staff should have published successes at performing these preclinical studies in woodchucks. The proposed award represents a continuation of work originally awarded to Cornell University under Contract N01-AI-05933 in 1999. Institutions which believe they have the requisite ability to perform this requirement may provide a capability statement identifying their business type e.g. educational institution, small business, large for-profit, etc.and a contact person and phone number within 45 days of this announcement. See Numbered Notes 22 and 26. No collect calls will be accepted. Questions regarding this action may be submitted to Brenda K. Lee on 301-402-2443.
 

Place of Performance

Address: Various Sites

Zip Code: null

Country: null
 

Record

SN00763700-W 20050309/050307211654 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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