SOLICITATION NOTICE
A -- Large-Scale Genotyping of NHLBI Cohorts
- Notice Date
- 3/18/2005
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-NHLBI-HC-06-03
- Response Due
- 7/6/2005
- Archive Date
- 7/21/2005
- Description
- The National Heart, Lung and Blood Institute (NHLBI) requires a Large-Scale Genotyping Center to expand the utilization of NHLBI's well-phenotyped observational cohorts and intervention studies for genetic association studies, through the application of large-scale genotyping and widespread data dissemination for genotype-phenotype correlation. The NHLBI is planning to issue a Request for Proposal (RFP) to solicit proposals for a Large-Scale Genotyping Center to perform high-throughput genotyping for candidate gene association studies on up to 50,000 participants in HLBS studies; and a genome-wide association study on roughly 500 disease cases and 1,000 controls. Studies with appropriate informed consent will be selected for participation by NHLBI prior to contract award based on programmatic balance across heart, lung, blood and sleep (HLBS) phenotypes; quality and breadth of phenotypic and environmental information; diversity of race/ethnicity, socioeconomic status, and geographic origin of participants; representativeness and generalizability of cohort to US population; and quality and quantity of DNA available for genotyping. The candidate gene association studies will involve in-depth characterization of more than 1700 candidate genes (8-10 Single Nucleotide Polymorphisms SNPs per gene region) on approximately 50,000 study members in heart, lung, blood, and sleep (HLBS) studies, for a total of more than 850 million genotypes (at a maximum cost, including labor, of $0.01 per genotype at initiation; costs are expected to decrease as technologies evolve). The genome-wide association study will be implemented in the second year of this program based on the evaluation of the analytic approaches and strategies produced by current genome-wide association studies such as studies funded through the Design and Analysis for Genome-wide Association Studies RFA. It will involve the use of a standard set of up to 300,000 state-of-the-art genetic variants in roughly 500 cases and 1,000 controls, for a total of roughly 450 million genotypes (at a maximum cost, including labor, of $0.01 per genotype at initiation; costs are expected to decrease as technologies evolve). The Genotyping Center must have the capacity to generate at least 850 million genotypes over two years with an error rate of no more than 1%. The NHLBI Large-Scale Genotyping Center will also develop informatic management processes for curation and cross-study data comparison, and provide a computing platform that facilitates data portability, accessibility, and security. The Genotyping Center must keep abreast of the evolving National Electronics Clinical Trials and Research (NECTAR) network as envisioned in the NIH Roadmap http://nihroadmap.nih.gov/clinicalresearch/overview-networks.asp, as well as the Cancer Biomedical Informatics Grid (caBIG), http://cabig.nci.nih.gov/ and the e-health record of the HHS National Health Information Infrastructure http://aspe.hhs.gov/sp/nhii/ as the computing platform and data set developed for dissemination must be capable of integration and interoperability with these platforms. The Genotyping Center will also establish comparable, resource-wide standardized phenotypes, controlled vocabularies including metathesaurus, thesaurus, and defined data elements mapped across participating population studies, and prepare uniform protocol models facilitating post-collection coordination and the evaluation of comparability across data sources. The Genotyping Center will integrate phenotypic and genotypic information pooled across studies, develop informatic management processes for curation and cross-study data comparison, and provide a computing platform that facilitates data portability, accessibility, and security. The Genotyping Center will process requests for use of the data generated including: receiving requests, ensuring up-to-date IRB approval and completion of data distribution agreements from requesting investigators, creating data sets, distributing data sets to investigators, and providing technical support (answering questions about data). The Center will also develop and implement plans for distribution of non-identifying summary data, such as allele frequencies, in public databases such as dbSNP. In addition, the successful offeror will facilitate, attend, and/or participate in Steering Committee and Oversight Committee calls and meetings, as required by the NHLBI. NHLBI expects to award one contract. The period of performance is anticipated to be for 4 years beginning on or about April 01, 2006. The RFP NHLBI-HC-06-03 will be available on or about April 4, 2005, and can be accessed from the website address: http://www.nhlbi.nih.gov/funding/inits/index.htm and FedBizOps at www.eps.gov/index.html. The electronic RFP will contain all the information needed to submit an offer. No printed version of the solicitation document or source list is available. All responsible offerors must submit a written proposal for the Government's consideration. Proposals will be due on or about July 06, 2005. This synopsis does not commit the Government to award a contract.
- Record
- SN00771467-W 20050320/050318211834 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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