SOURCES SOUGHT
A -- Simian Vaccine Evaluation Units
- Notice Date
- 3/18/2005
- Notice Type
- Sources Sought
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Program 6700 B Rockledge Room 3214 MSC7612, Bethesda, MD, 20892-7612
- ZIP Code
- 20892-7612
- Solicitation Number
- SS-NIH-NIAID-DMID-06-15
- Response Due
- 4/1/2005
- Archive Date
- 4/16/2005
- Description
- The Division of Acquired Immunodeficiency Syndrome (DAIDS), of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is seeking capability statements from organizations with technical expertise and facilities to house 100 ? 300 nonhuman primates in BSL2 and BSL2/3 containment facilities and to conduct preclinical evaluations of the immunogenicity and efficacy of simian immunodeficiency virus (SIV) and HIV candidate vaccines in the nonhuman primates. The Contractor will provide the nonhuman primates and the scientific and technical expertise necessary to conduct preliminary studies of new vaccines; conduct larger-scale studies of vaccines that have already demonstrated promise; evaluate the immunogenicity and safety of candidate HIV vaccines (or immunogenicity, safety, and efficacy of SIV vaccines which parallel HIV vaccines in approach) in anticipation of Phase I human clinical trials; and conduct comparative studies on vaccines and/or adjuvants from multiple sources. The SVEUs may also conduct studies with passively administered vaccines and in vivo titrations of virus challenge stocks when requested. In addition to providing nonhuman primates for the studies, the SVEUs are expected to immunize animals with candidate vaccines; conduct initial assessments of immune responses; challenge the non-human primates with infectious virus; and determine whether or not the animals become infected. SVEUs may also conduct microbicide studies in order to evaluate the ability of topically administered microbicides and other antiviral substances to block infection of non-human primates with virus administered vaginally or by other mucosal routes. This is a continuing effort. There are three incumbents. Potential sources must demonstrate and document the following in their capability statements: 1) The availability of a well equipped and maintained AAALAC (Association for the Assessment and Accreditation of Laboratory Animal Care)-accredited facility with the capacity for housing and conducting studies with 100-300 nonhuman primates in appropriate biohazard containment facilities, using appropriate biosafety procedures to care for and handle virus-infected animals. Animals may be housed in BSL-2 biohazard containment facilities until exposure to infectious SIV, SHIV, or related retroviruses. After virus exposure, biohazard containment shall be at the BSL-2 level, using BSL-3 practices. 2) The availability of experienced veterinary and animal care staff to care for and conduct studies with nonhuman primates. 3) The availability of staff with demonstrated experience and expertise in the conduct, management and direction of SIV or HIV vaccine studies. 4) The availability of a BSL-2 or BSL-3 biohazard containment laboratory facility and experienced staff to conduct in vitro procedures and assays with samples from uninfected or retrovirus-infected nonhuman primates. 5) Established plans for acquisition of nonhuman primates, including a description of any current, established source of nonhuman primates, any past history of sources previously used, and the proposed sources to be used to acquire nonhuman primates for studies. Interested Small Business organizations should submit two (2) copies of their capability statement addressing each of the areas cited above. See Numbered Note 26. No collect calls will be accepted. No facsimile transmissions will be accepted. THIS IS NOT A REQUEST FOR PROPOSALS AND DOES NOT COMMIT THE GOVERNMENT TO AWARD A CONTRACT NOW OR IN THE FUTURE. NO SOLICITATION IS AVAILABLE AT THIS TIME. BASED ON CAPABILITY STATEMENTS RECEIVED FROM THIS SOURCES SOUGHT, THIS ACQUISITION MAY BE SOLICITED AS A 100% SMALL BUSINESS SET-ASIDE, NAICS CODE 541710, WITH A SIZE STANDARD OF 500 EMPLOYEES.
- Record
- SN00771475-W 20050320/050318211841 (fbodaily.com)
- Source
-
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