MODIFICATION
R -- Yeast Two-Hybrid Screening
- Notice Date
- 3/21/2005
- Notice Type
- Modification
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases/AMOB, 10401 Fernwood Drive, Suite 2NE70, MSC 4811, Bethesda, MD, 20817
- ZIP Code
- 20817
- Solicitation Number
- NIAID-DIR-05-42
- Response Due
- 3/23/2005
- Description
- **The purpose of this modification is to correct the response date. Capability statements should be submitted by March 23, 2005.*** The National Institute of Allergy and Infectious Diseases (NIAID), Acquisitions Management and Operations Branch (AMOB) is seeking sources that can provide yeast two-hybrid analysis of proteins. Offerors must be capable of analyzing each protein as multiple overlapping fragments engineered as DNA-binding domain constructs (DBD Constructs); preparing custom activation domain libraries; generating and screening each of the DBD Constructs against up to three different activation domain libraries; reproducing all interactions in na?ve yeast and confirming specificity using multiple microbial DBD Construct controls; providing continuous access to the protein interaction data via a secure, web-based interface; and providing access to a curated database of publicly reported protein-protein interactions. Offerors must have significant operational experience utilizing yeast two hybrid screening technology to detect host-pathogen protein-protein interactions. NIAID intends to award a one year contract beginning on or about May 1, 2005 with the option for four additional contract years. This is not a request for proposals. The intention of this announcement is to survey the market for potential offerors. Potential offerors must provide a capability statement to Terrie Nestor at tnestor@niaid.nih.gov on or before March 17, 2005 at 2:00pm. Capability statements must indicate the business size of the company.
- Place of Performance
- Address: N/A
- Record
- SN00772389-W 20050323/050321211739 (fbodaily.com)
- Source
-
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