SOLICITATION NOTICE
A -- DEVELOP & EXTEND A BIOMATHEMATICAL MODEL IN RATS TO DESCRIBE PARTICLE SIZE-SPECIFIC CLEARANCE & TRANSLOCATION OF INHALED PARTICLES & EARLY BIOLOGICAL RESPONSES
- Notice Date
- 6/22/2005
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, Center for Disease Control and Prevention, Acquisition and Assistance Field Branch (Morgantown), 1095 Willowdale Road, Morgantown, WV, 26505
- ZIP Code
- 26505
- Solicitation Number
- 2005-Q-02123
- Response Due
- 7/8/2005
- Archive Date
- 9/20/2005
- Description
- The National Institute for Occupational Safety and Health, Cincinnati, Ohio requires a need to Develop and Extend a Biomathematical Model in Rats to Describe Particle Size-Specific Clearance and Translocation of Inhaled Particles and Early Biological Responses. The purpose of this RFQ is to develop an integrated and extended dosimetry model in rats to quantitatively describe the fate of, and biological responses to, inhaled particles by size and other particle characteristics. This biologically-based mathematical model will go beyond existing models by integrating into a single modeling framework the following features: particle size-specific processes of deposition, clearance, and retention of particles in the respiratory tract; translocation beyond the respiratory tract to other organs in the body, by particle characteristics (e.g., size and composition); and biological responses in the lung and other tissues. This integrated and extended model will provide a quantitative, scientific basis for extrapolating the exposure, dose, and response data in rats to humans for use in risk assessment. The model structure will be developed based on validated biological principals and published data on the physiological and physical processes involved in the fate of inhaled particles of various characteristics (e.g., size and composition), as well as on data of the particle dose and biological responses. Although models have been developed to describe the particle size-specific deposition in the respiratory tract, current models of the clearance and retention of particles are based on the mass transfer of all particles that deposit in a given region of the respiratory tract. Among the respirable size particles, which are defined as those that deposit in the gas-exchange region of the lungs, the nanoparticles (<100 nm) have been observed to retard alveolar macrophage-mediated clearance to a greater extent than an equal mass or volume of larger particles (Renwick et al. 2001; Oberd?rster et al. 1992; Morrow et al. 1991). The surface area of particles was found to describe better the particle size effect on alveolar macrophage-mediated clearance (Tran et al. 1999). Both the particle size and composition (or surface properties) appear to influence translocation rates from the lungs to the blood and other organs or tissues (Tran et al. 1999, 2001; Oberd?rster et al. 2002; Kreyling et al. 2002). Finally, nanoparticles depositing in the nasopharyngeal region may translocate to the brain (Oberd?rster et al. 2004). These clearance and translocation processes are not described in current lung dosimetry models; yet these processes may be critical determinants of the internal dose, and thus response, to inhaled nanoparticles. This RFQ includes the tasks needed to develop a biomathematical model structure to describe the clearance, retention, and translocation of inhaled particles, by size and composition, with emphasis on nanoparticles. The particle size-specific deposition in the rat lungs will be estimated using a published rat lung deposition models (e.g., Anjilvel and Asgharian 1995; CIIT and RIVM 2002), and these estimates will be input into the overall model. The coefficients for clearance, retention, and translocation will be estimated from data in published rat studies (e.g., Oberd?rster et al. 1992, 2002, 2004); Tanaka et al. 2001; Kreyling et al. 2002). The calibrated model will be used to estimate the retained dose of nanoparticles in the lungs and other organs in ongoing NIOSH studies in rats. When those NIOSH studies are completed (not part of this RFQ), the results will be used to evaluate the model predictions, and to further validate the model developed and calibrated in this RFQ. Minimum Qualifications 1. Personnel Requirements: The successful awardee must have personnel with education, work experience, and publications in the areas of biologically-based mathematical and statistical modeling. The principal investigator must have attained at least a doctoral degree in the areas of mathematics, statistics, or biostatistics; or in biological, health, or physical sciences with a demonstrable quantitative emphasis at the doctoral level. All key personnel must have attained at least a bachelor degree in the areas of biological or physical sciences, mathematics, statistics, or engineering. The principal investigator must have at least five years of work experience in biologically-based mathematical modeling. All key personnel must have work experience for at least one year in jobs involving biologically-based mathematical and/or statistical modeling. The principal investigator must have at least three scientific publications in which the methods involve the development of biologically-based mathematical models, and at least one of these publications must involve modeling the disposition of, and response to, inhaled particles in the lungs of rodents and/or humans. 2. Methods requirements: The successful awardee must demonstrate a thorough knowledge of the approach to be used in the conduct of this procurement. The specific approach to be used should be described, along with a discussion of why the proposed approach will produce results which answer questions concerning the disposition of, and biological response to, inhaled particles (by size and other characteristics) in rodent lungs. The relevance of using these modeling results in human health risk assessment should be described, including extrapolation of these models to humans. This procurement is being issued unrestricted. Solicitation 2005-Q-02123 will be available on or about July 11, 2005 and proposal due on August 11, 2005. No telephone requests will be accepted. Organizations interested in receiving a copy of the solicitation may submit a written request to DHHS/PHS/CDC/NIOSH/ALOSH, ATTN: Rebecca Mullenax, MS L-1019, 1095 Willowdale Road, Morgantown, WV 26505. Please reference the solicitiation number in your request. Only written requests for the solicitation will be honored. Requests may be mailed, or faxed to 304-285-6083 or e-mailed to RMULLENAX@CDC.GOV.
- Place of Performance
- Address: DHHS/PHS/CDC/NIOSH, CINCINNATI, OHIO
- Record
- SN00834370-W 20050624/050622211815 (fbodaily.com)
- Source
-
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