SOLICITATION NOTICE
R -- Development of Avian Paramyxovirus (APV) Vaccine Vectors
- Notice Date
- 6/27/2005
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases/AMOB, 10401 Fernwood Drive, Suite 2NE70, MSC 4811, Bethesda, MD, 20817
- ZIP Code
- 20817
- Solicitation Number
- Reference-Number-SS-NIAID-05-01-RFP-06-28
- Response Due
- 7/22/2005
- Archive Date
- 8/6/2005
- Description
- The Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), has a requirement for services from a qualified source to provide the necessary personnel, material, equipment, and facilities not otherwise provided by the Government, to characterize naturally occurring avian paramyxoviruses (APV) and identify strains suitable for further development as vaccine vectors to express antigens of highly pathogenic agents for human immunization. The contractor will support intramural NIAID pre-clinical research work to identify APV that are infectious and attenuated in non-human primates acting as surrogates of humans, that are not highly pathogenic in birds, that replicate in Vero cells, and that can be made into recombinant form and engineered to express antigens of highly pathogenic human viruses to induce satisfactory immune responses in non-human primates. Specifically, the Contractor shall: prepare working pools of APV (in particular avian parainfluenza viruses and avian metapneumoviruses); characterize each APV strain with regard to replication in vitro; perform antigenic analysis; prepare biologically cloned virus suspensions; perform replication and pathogenicity in birds and embryonated eggs; perform replication in hamsters; support LID/NIAID primate studies; perform sequence analysis; perform reverse genetic studies; support construction and analysis of APV-based vectored vaccines; complete studies with highly pathogenic agents; deliver results and materials; and maintain records and biological materials. Offerors will be evaluated on the experience and capabilities of professional and technical personnel that would be assigned to this project; established capability for laboratory work and animals testing (rodents or chickens) at ABSL-2 and ABSL-3; and experience with viral infection of animals and virus isolation from animals at ABSL-2 and ABSL-3. The Offeror must also have, or be able to obtain, Select Agent approval for work with highly pathogenic avian influenza viruses (e.g., H5 and H7) as well as approval by the United States Department of Agriculture for work with the above-mentioned highly pathogenic avian viruses as well as with Newcastle disease virus mesogenic strains. The Request for Proposals (RFP) will be available electronically on/about July 22, 2005, and may be accessed through the FedBizOpps Home Page at www.fedbizopps.gov. It is anticipated that one cost reimbursement type award will be made on or about December 1, 2005, for a base year, including options for five additional years. Contact Point: Ivan Hernandez, Contracts Specialist, Acquisition Management and Operations Branch National Institutes of Allergy and Infectious Diseases, National Institutes of Health 10401 Fernwood Road, Room 2NE-06, MSC 4813, Bethesda, MD, 20892-4813 Tel. 301-402-6954; email: ihernandez@niaid.nih.gov This announcement does not commit the Government to award a contract. Collect calls will not be accepted. Note: Both current and potential government vendors are required to register in CCR (www.ccr.gov) in order to be considered for award of a government contract. This includes Vendors required to complete a one-time registration to provide basic information relevant to procurement and financial transactions. Vendors must update or renew their registration annually to maintain an active status. Both current and potential government vendors are required to register in CCR in order to do be awarded contracts by the government. Additionally, the Federal Acquisition Regulation (FAR) now requires the use of the Online Representations and Certifications Application (ORCA) in Federal solicitations as part of the proposal submission process. ORCA is a web-based system that centralizes and standardizes the collection, storage and viewing of many of the FAR required representations and certifications previously found in solicitations. ORCA gives current and potential government vendors the ability to enter and maintain representation and certification information, at their convenience, via the Internet at http://orca.bpn.gov.
- Place of Performance
- Address: Contractor's Site
- Record
- SN00836979-W 20050629/050627211818 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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