SOLICITATION NOTICE
B -- Development of Statistically Based Quantitative Structure-Toxicity Relationship (QSTR) Models for Predicting the Sub-Chronic Toxicity Benchmarks for a Variety of Chemicals
- Notice Date
- 7/6/2005
- Notice Type
- Solicitation Notice
- Contracting Office
- Contracts Management Division 26 W. Martin Luther King Drive Cincinnati, OH 45268
- ZIP Code
- 45268
- Solicitation Number
- PR-CI-05-10965
- Small Business Set-Aside
- N/A
- Description
- The U.S. Environmental Protection Agency (U.S.EPA), National Homeland Security Research Center (NHSRC), seeks a contractor to use the experimental sub-chronic toxicity benchmark (in the form of a LOAEL, BMD, or BMDL10) data to develop predictive models to estimate the sub-chronic toxicity of a variety of chemicals through the use of Quantitative Structure-Toxicity Relationships (QSTRs). The contractor shall develop a separate QSTR model for each of the above-mentioned benchmarks. QSTRs are mathematical equations that describe correlations between various descriptors of molecular structures of chemicals and their observed biological activities. The resulting mathematical equations can then be used to calculate the biological activities of new chemicals or other chemicals that lack experimental toxicity data. The descriptors should be able to quantify the transport, bulk and electronic attributes of a molecular structure that are responsible for the observed biological activity. In this research, NHSRC will provide the contractor with the sub-chronic toxicity benchmark data, including toxic endpoints, and relevant experimental citations for approximately 200 to 500 chemicals. The contractor shall calculate descriptors for these chemicals using common descriptor generator programs similar to Computer Aided Chemistry (CAChe), Codessa, Molconn-Z, Dragon, and other commercial or non-commercial descriptor generator tools. The contractor shall reveal the source and the details for both the commercial and non-commercial descriptor generator tools, and provide NHSRC details on obtaining the software such that NHSRC can duplicate some of the work. Such descriptor generator tools should be capable of generating descriptors using both 2D and 3D structures. Each proposed QSTR should be a statistically robust model that can 1) predict the sub-chronic toxicity benchmarks for a variety of chemicals that lack experimental toxicity data, 2) recognize the varying toxic effects of isomers, and 3) incorporate mode and mechanism of action if these data are available and provided by NHSRC. In addition to developing the QSTR models, the contractor shall test the predictive ability of the model by using at least 10 percent of the database chemicals as test chemicals. The contractor shall also group the final QSTRs into sub-models based on chemical classification and test these sub-models for their predictive ability. The proposed contract will have period of performance of 13 months. It is anticipated that a firm-fixed contract will result from this solicitation. The current projected start date of the contract is February 1, 2005. The applicable NAICS code is 541990 with a size standard of $6 Million. The solicitation will appear on the Internet under Solicitation Number PR-CI-05-10965. It may be accessed through the EPA?s home page on the World Wide Web (www.epa.gov). The direct link URL is http://www.epa.gov/oam/cinn_cmd. All responsible sources who submit a proposal will be considered by the Agency. It is the responsibility of offerors to check FedBizOpps or the EPA website address for updates or changes. It is anticipated that this RFP will be available after August 10, 2005.
- Web Link
-
The Environmental Protection Agency
(http://www.epa.gov/oam/solicit)
- Record
- SN00842403-W 20050708/050706212605 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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