SOLICITATION NOTICE
B -- Defining Molecular Subtypes of Lymphoma for Relevance to Survival, Etiology, and Diagnosis
- Notice Date
- 8/30/2005
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-50161-NG
- Response Due
- 9/9/2005
- Archive Date
- 9/24/2005
- Description
- The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG), plans to procure on a sole source basis, services regarding: Defining molecular subtypes of lymphoma for relevance to survival, etiology, and diagnosis with University of Nebraska Medical Center, Eppley Institute for Cancer Research, Omaha, NE 68198-5440. The supplies and services herein are being procured in accordance with the simplified acquisition procedures authorized by FAR Part 13. The North American Industry Classification System code is 541710 and the business size standard is 500 employees. Diffuse large B-cell lymphoma (DLBCL) is the most heterogeneous and most common type of non-Hodgkin lymphoma (NHL). Recent cDNA microarray gene expression studies have revealed two distinct DLBCL subtypes (germinal center B-cell?like DLBCL (GCB-DLBCL) and post-GCB-DLBCL) with clinical relevance, distinct normal cell counterparts, and occurrence of distinct oncogenic events. The goal of the present work is therefore to: 1) classify the DLBCL cases in the NCI-SEER NHL Case?Control Study by t(14;18) translocation status using interphase fluorescence in situ hybridization (FISH); 2) assess the prognostic significance of the t(14;18) translocation in our large, population-based sample and; 3) evaluate potential etiologic differences by t(14;18) translocation status. The University of Nebraska has: 1) developed and optimized the required protocol in paraffin-embedded tissues, 2) has the required equipment to carry out the protocol, and, 3) recently published results from a study of t(14;18) translocation in paraffin-embedded tissues from the late 1980?s with a failure rate of < 1%. No other laboratory has published equivalent data using this protocol. NCI requires that the conduct of interphase FISH to identify the t(14;18) translocation status of DLBCL cases in the NCI-SEER Case?Control Study population be conducted at the University of Nebraska. The University of Nebraska is the only source known to the NCI that can provide the aforementioned services and facilities. This notice is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office by 1:00 PM EDT, on September 9, 2005. For further information please contact Malinda Holdcraft, Contract Specialist via electronic mail at holdcram@exchange.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. No faxed or emailed capability statements will be accepted. In order to receive an award, contractors must be registered in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA). Reference NCI-50161-NG.
- Record
- SN00882397-W 20050901/050830211813 (fbodaily.com)
- Source
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