Loren Data's SAM Daily™

FBO DAILY ISSUE OF OCTOBER 06, 2005 FBO #1410
SOURCES SOUGHT

R -- Synthesis of Selected Chemical Carcinogens, Derivatives of Polynuclear Aromatic Hydrocarbons (PAH) and Chemopreventive Agents

Notice Date

4/12/2005
 

Notice Type

Sources Sought
 

NAICS

541710 — Research and Development in the Physical, Engineering, and Life Sciences
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
 

ZIP Code

20852
 

Solicitation Number

N02-CB-57021-48
 

Response Due

5/27/2005
 

Point of Contact

John Manouelian, Contract Specialist, Phone (301) 435-3813, Fax (301) 402-6699, - Richard Hartmann, Contracting Officer, Phone (301) 496-8620, Fax (301) 402-6699,
 

E-Mail Address

jm486p@nih.gov, rh75f@nih.gov
 

Description

DESC: THIS IS NOT A REQUEST FOR PROPOSAL. The National Cancer Institute intends to procure the services of the Hershey Medical Center of the Penn State College of Medicine, 500 University Drive, Hershey, PA 17033. The support services are needed for the Cancer Etiology Branch of the Division of Cancer Biology as a follow-on contract to complete current requirements associated with Contract No. N02-CB-37025. Background: the Cancer Etiology Branch (CEB) of NCI’s Division of Biology, has a continuing requirement for the synthesis, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. The compounds are to be prepared in exploratory syntheses on a small scale and then prepared in a production run to yield one to several grams of sufficiently pure material (generally 99+ percent). Compounds are to be characterized by a meaningful combination of appropriate techniques including specific activity; melting points; ultraviolet, visible and infrared spectroscopy; and NMR or mass spectroscopy. Major responsibilities are: (1) resynthesis of polycyclic aromatic hydrocarbon PAH derivatives by established procedures for the restocking of NCI’s Chemical Carcinogen Reference Standards Repository as necessary, and (2) development of synthesis of selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives. Distribution to the research community will be handled by the repository contractor all labeled and unlabeled compounds. Labeled compounds will be subdivided and shipped to designated recipients in the research community either directly by the synthesis contractor or through the repository contractor. The contractor shall be required to provide analytical, handling, and storage data with all shipments. A high degree of cooperation with NCI, the repository contractor, and other synthesis program contractors is necessary. The Government anticipates one contract will be awarded on an incrementally funded basis for a total period of one (1) year. The particular requirement for this contract centers around syntheses of chemical compounds from the following three categories: Polycyclic Aromatic Hydrocarbons (PAHs) and their metabolites (including 1-hydroxybenzo[a]pyrene, 5-hydroxybenzo[c]phenanthrene, 11-hydroxybenzo[a]pyrene, 6,12-dimethylchrysene, anti-11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrobenzo[g]chrysene, anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5,6-dimethylchrysene); Nitrosamines and tobacco-specific nitrosamines (including NNK and its metabolites, N-Methyl-N-nitroso-N-nitroguanidine, N-Nitrosoguavacoline, N-Nitroso methyl benzylamine); and Chemopreventive agents (including SAHA and PBIT). Since the intermediates and synthetic schemes have been developed by the investigators employed with the Hershey Medical Center, they meet the requirements of the FAR 6.302-1 (a)(2), in that they are the only responsible source that will satisfy the agencies requirements without significant cost in the loss of time and materials already invested in these syntheses. The estimated period of performance is September 30, 2005 through September 29, 2006. The NAICS Code is 54170. Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. Numbered Note 22 applies. No Collect Calls accepted. NOTE: THIS NOTICE MAY HAVE POSTED ON WWW.FEDBIZOPPS.GOV ON THE DATE INDICATED IN THE NOTICE ITSELF (12-APR-2005). IT ACTUALLY APPEARED OR REAPPEARED ON THE FEDBIZOPPS SYSTEM ON 04-OCT-2005, BUT REAPPEARED IN THE FTP FEED FOR THIS POSTING DATE. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
 

Web Link

Link to FedBizOpps document.
(http://www.eps.gov/spg/HHS/NIH/RCB/N02-CB-57021-48/listing.html)
 

Place of Performance

Address: Hershey Medical Center Penn State College of Medicine 500 University Drive Hershey, PA 17033

Zip Code: 17033

Country: USA
 

Record

SN00909562-F 20051006/051004213526 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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