SOLICITATION NOTICE
B -- Special Studies and analyses
- Notice Date
- 3/15/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-PG(AR)-2006-132-CDM
- Response Due
- 3/30/2006
- Archive Date
- 4/14/2006
- Small Business Set-Aside
- Total Small Business
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Consolidated Operations Acquisitions Center (COAC) for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to negotiate an award a purchase order on a noncompetitive basis to Quince Valley Informatics Inc., 12127 Sheets Farm Road, Gaithersburg, Maryland 20878, to continue the services for the NIAMS. The major component of the services is the development of the Microarray Data Management & Analysis System (MDMAS) and the conduction of biomedical research with computational approaches for a number of existing and related projects. The Statement of work (SOW) is as follows: Specifically, the contractor shall: 1) continue to design, develop, and implement research and clinical databases. This includes the continued development of MDMAS with the following substantially enhanced features: a) Design and implement p-value, fold change, and P/A call based screening functions; b) Design and implement functions to generate gene lists obtained under different screening criteria; c) Design and implement functions to store GeneChip data processed by RMA (Robust Microarray Analysis), including integrating the P/A calls from MAS5. RMA is an increasingly popular algorithm for summarizing Affy?s probe level data. Since it does not consider the data from the mismatch probes, integration of the P/A calls from MAS5 is necessary to allow P/A calls based gene screening; d) Design and implement functions to store the .cel files from the Affy system. The storage of .cel files will allow use of probe summarization algorithms other than MAS5 (Affy?s), such as RMA and PDNN, both are generally considered better than MAS5; e) Implement Welch variance (unequal variance) in addition to the equal variance currently implemented for t-test; f) Resolve the issue related to paired t-test, implementing functions to allow a user to specify the order of samples for both sample groups; g) Fix the deletion related bugs and implement more delete functions (currently very limited); h) Implement data sharing so a user can grant read and/or write privileges to group members; i) Implement privilege control to allow group leader/PI to group-wide access; j) Implement super user privileges to allow power users (experts) to analyze any user?s data; k) Replace ?rough? codings resulted from the quick-and-dirty strategy with robust and less error-prone ones; l) Work with SITB to deploy the system to a NIH owned Unix Server and solve any porting related issues; m) Develop a server specific backup protocol as needed; and n) Develop a user guide. 2) Design and implement biodata mining strategies, methods, and algorithms for scientific discovery; 3) Explore and evaluate database based research tools and techniques in the emerging and rapidly developing fields such as Bioinformatics, systems biology, and proteomics; 4) Provide training and educational seminars to the Intramural Research Program (IRP); 5) Provide other related databases services as needed, provide strategic and technical advise on existing and ongoing clinical database and related projects; 6) Provide database application training to the IRP researchers; 7) Participate in the data mining projects in collaboration with other IRP investigators. The Government will provide to the Contractor a computer system. The Chief of Biodata Mining & Discovery section will perform quarterly reviews, inspection, progress and approval of the work. The acceptance of the work will be done within the last month of the contract. Deliverables: The Contractor shall deliver the MDMAS with the enhanced features and the satisfactory performance to the requirements specified above. The period of performance is for twelve (12) months beginning on the following day of the contract award date. The place of performance is at NIH, Bethesda Maryland . The sole source determination is based upon the continuation of the development of the MDMAS and related services initiated by Quince Valley Informatics Inc. An award to any other source would result in a substantial duplication of cost to the Government that is not expected to be recovered through competition. This acquisition is being conducted under FAR Part 13, simplified acquisition procedures. It is noted that FAR Part 6, Competition Requirements, is not applicable simplified acquisition. The North American Industry Classification System (NAICS) applicable to this requirement is 541690, Size Standard $6 million dollars. This notice of intent is not a request for competitive proposals. Interested parties are requested to review the above requirements, submit a statement of interest which includes a firm fixed price; documentation of similar projects conducted and the benefits in obtaining the Government?s objectives; at least three (3) references documenting successful past performance in meeting the Government?s minimum requirements, a proposed delivery plan and meet the following technical evaluation criteria: 1) Demonstrated knowledge and understanding of the SOW as specified in this synopsis, 2) Demonstrate that the person performing this job to have experience on the related field of this project, a Ph.D. from an accredited University in the biological field, Demonstrate a minimum of five (5) years of experience on microarray database development, technical expertise with PHP - Hypertext preprocessor computer language - used specifically to develop web-interface of database, demonstrate statistical background required for microarray data manipulation, 3) proof of past performance. The submission will be evaluated on the submission of the above documents. The submission is due on March 30, 2006, 9:00 a.m. The submission must also include any prompt payment discount terms, the Dun & Bradstreet number (DUN?s), the Taxpayer Identification Number (TIN) and the Offerors Business size. The Offeror must also register in the Government?s Contractor Registry System. Note: ?http://www.ccr.gov.? The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct future competitive procurement. Responses to this announcement, referencing synopsis number NHLBI-PS-(AR)-2006-132-CDM, may be submitted by mail to the National Heart, Lung, and Blood Institute, Consolidated Operations Acquisitions Center (COAC), Office of acquisitions, Procurement Branch, 6701 Rockledge Drive, Rockledge Building 2, Suite 6042, Bethesda, Maryland 20892-7902, Attention: Cecilia Morales, by fax transmission to (301) 480-3345 or by email to moralesc@nhlbi.nih.gov. All responsible sources may submit information, which if timely received, shall be considered by the agency
- Place of Performance
- Address: BETHESDA, MD.
- Zip Code: 20892-0001
- Country: USA
- Zip Code: 20892-0001
- Record
- SN01006824-W 20060317/060315211912 (fbodaily.com)
- Source
-
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