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FBO DAILY ISSUE OF APRIL 23, 2006 FBO #1609
SOLICITATION NOTICE

B -- Data Collection of Interviews, Clinical Assessment and Blood from the Newborn Epigenetics Study (NEST)

Notice Date

4/21/2006
 

Notice Type

Solicitation Notice
 

NAICS

541990 — All Other Professional, Scientific, and Technical Services
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
 

ZIP Code

20852
 

Solicitation Number

Reference-Number-NCI-60059-NE
 

Response Due

5/5/2006
 

Archive Date

5/20/2006
 

Description

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Human Carcinogenesis (LHC), plans to procure on a sole source basis, for Data collection of interviews, clinical assessment and blood from the Newborn Epigenetics Study (NEST), with Duke University Medical Center (DUMC), Box 2949, Durham, NC 27510. The acquisition is being conducted under the simplified acquisition procedures authorized in FAR Part 13. The North American Industry Classification System Code is 541990 and the business size standard is $6M. Background: The Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, requires the development of a database for and the performance of laboratory analyses of cord blood of neonates born to African- American and non-Hispanic white women, who are smokers or non-smokers, as part of the study known as The Newborn Epigenetics Study (NEST). Exposures in utero will be examined in relation to methylation and imprinted genomic patterns in cord blood. Mothers of the newborns will provide reported information about prenatal events and maternal lifestyle during the index pregnancy and the maternal data will be linked to laboratory analyses of the neonate?s cord blood. In utero methylation patterns are established for life and DUMC is the only known laboratory in the United States with recognized capability to perform these analyses in humans. The results of the data collection and laboratory analysis of the NEST, will contribute to NCI?s understanding of the potential role of methylation and imprinted genomics in two different ethnic groups in the United States as well as the role of maternal smoking in pregnancy on methylation status of the newborn. Because methylation patterns are established in utero, this pilot study will provide the first ever analysis of cord bloods in children of African American and non-Hispanic white descent. This pilot study will also nvestigate whether maternal smoking and diet in pregnancy modify methylation status at birth. Thus, the overall objective is to determine whether fetal exposures are related to risk factors for cancer, and to develop documentation of major early life exposures such as maternal smoking and diet during the pregnancy of the index newborn; perform laboratory analyses to identify epigenetic patterns at birth; and develop a database with coded items for subsequent analysis of the data. DUMC has on its staff the Principal Investigators on the NEST, who are responsible for oversight of data and biospecimen collections as well as the laboratory analyses. The Department of Oncology at DUMC is where the major emphasis on genomic imprinting and cancer has evolved. DUMC also has on staff the Principal Investigator for the cord blood bank at Duke Medical Center who has many years experience in biospecimen collections of population-based birth cohort data at birth. Period of Performance: Estimated four (4) months. Duke University Medical Center is the only known source that can provide the aforementioned requirements. Because all laboratory analysis including epigenetic methylation patterns from early life exposures have been performed at Duke University Medical Center and are approved by the Institutional Review Board of the Duke University Medical Center, this unit is the only source known to the NCI that is familiar with the original assays required as well as perfected the techniques used in cord blood methylation patterns and genetic profiles. This notice of intent is not a request for competitive quotation. However, if any interested party believes it can meet the above requirements, it may submit a statement of capabilities. The capability statement and any other furnished information must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can fully meet the requirements herein. Capability statements must be received in the contracting office by 1:00 PM EST on May 5, 2006. If you have any questions; please submit them in writing via electronic mail to Karen Gardner, Contract Specialist at gardnerka@mail.nih.gov or by fax 301-402-4513. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Information received shall be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered with the Central Contractor Registration (CCR) and the online Representations and Certifications Applications (ORCA).
 

Place of Performance

Address: Durham, NC

Zip Code: 27708

Country: USA
 

Record

SN01032573-W 20060423/060421220508 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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