MODIFICATION
66 -- Triple Quadrupole Mass Spectrometer
- Notice Date
- 7/20/2006
- Notice Type
- Modification
- Contracting Office
- Environmental Protection Agency, Acquisition Management Branch, 26 W Martin Luther King, Cincinnati, OH 45268
- ZIP Code
- 45268
- Solicitation Number
- RFQ-OH-06-00174
- Response Due
- 8/1/2006
- Archive Date
- 9/1/2006
- Description
- NAICS Code: 334516 The purpose of this amendment is to correct symbols listed in the specifications, that appeared as questionmarks . Procurement Specifications for the Triple Quadrupole Mass Spectrometer I. Triple Quadrupole Mass Spectrometer Specifications A) A triple quadrupole mass spectrometer that is able to measure fumigants such as chlorine dioxide and vaporous hydrogen peroxide, fumigant generation byproducts such as chlorine (Cl2), 1-chloro-2-propanone, 1,1-dichloro-2-propanone, methyldichloroacetate, chloroform, carbon tetrachloride, acetone, formaldehyde, acetaldehyde, benzaldehyde, and other decontamination products. The mass spectrometer must be equipped with a low pressure chemical ionization source and an atmospheric pressure chemical ionization (APCI) source and both sources must use direct air sampling inlet. Each of the following specifications must also be met: 1) The sample inlet must be able to maintain the specified reduced pressure (see item 2) for the ionization source. 2) The pressure in the low pressure chemical ionization chamber shall be able to be adjusted from 0-10 torr ?0.01torr. 3) The system must have in-line pressure gauges for both ionization sources and for the mass spectrometer. The gauge on the low pressure source must be able to measure pressure from 1-10 torr ? 0.001 torr. 4) A townsend discharge shall be the ion generation method in the low pressure chemical ionization chamber. 5) The mass filters in the first and third quadrupole must have range from 10-1500 amu. 6) The process of switching the ionization source must take less than 1.5 hours and the resulting system pump down must take less than 12 hours. 7) Detection limits are defined as 3 times the standard deviation of the parent/daughter ion pair signal in a purified air or solvent blank divided by the response factor (the slope of the calibration curve for the compound) that was determined using a standard in a balance of the same air blank. The limits of detection for the compounds listed above, specifically the organic compounds (in the vapor phase), must be in the 10 ppb volume range in air using either the APCI or LPCI ionization source. For these determinations the most sensitive ion pairs shall be viewed in selected ion mode. These limit of detections shall be achieved under the following mass spectrometer conditions: " 100 ms dwell time " 10 ms rest time " 0.5 amu widths at half height with Gaussian peak shape for both quadrupole 1 and 3 when they are used at the same time " Argon gas as the collision gas in quadrupole 2 (the collision chamber) 7) The linear range for these compounds shall be 5?105 and the dynamic range for these compounds shall be 5?106. 8) The APCI source must be easily interfaced with the Liquid Chromatograph (LC) and be capable of operating as a traditional electrospray source. The LPCI source must be easily interfaced to a Gas Chromatograph. 9) The mass spectrometer (including one ionization source) must be smaller than 29" deep. 10) The instrument must be listed and labeled by a third party listing agency approved by the North Carolina Building Code Council. Additionally prior to shipping unlisted equipment to the EPA, a field inspection performed by an approved agency (see attachment). The field inspection shall be performed at the manufacturer's place of business and shall be included in the vendor's quotation. If the equipment fails the field inspection, the vendor shall make necessary changes to meet the listing agency's approval B) A gas chromatograph (GC), liquid chromatograph (LC), and direct insertion probe (DIP) must also come with the mass spectrometer and should meet the following specifications: 1) The GC shall have a split/splitless injector. The oven of the GC shall be able to ramp at rates ranging from 1?C in 10 minutes to 50 ?C in 10 minutes and the oven shall be able to reach to 350 ?C. 2) The user shall be able to automatically adjust solvent gradients for the LC and the LC must also include a syringe pump for injections onto the column. 3) A direct insertion probe must also be included for the analysis of solids C) Computer Hardware and Software 1) The PC Workstation at a minimum should have: 3.4 GHz processor speed, 1 GB RAM, 160 GB hard drive, 12x-CD-RW, 3 USB ports, and integrated Ethernet. 2) All parameters of GC, LC, ionization sources, and mass spectrometer must be controlled by the software. 3) Filament delay, tuning of the mass spectrometer, and the ionization process should also be controlled by the software. 4) The software must be section 508C compliant. D) Data Handling- The data handling system shall be capable of the following functions: 1) The parent/daughter ion pairs, parent/parent ions or total ion current must be viewable in real time. The x axis on the total ion current shall either be time or sequence number. 2) Calculation of calibration curves (response factors) when multi component standards are introduced into the system even when a there is no front end on the instrument (i.e. direct air sampling). 3) The software can calculate response factors regardless of how the standard is introduced (i.e. cylinder, syringe pump, diffusion tube) and regardless if a front end is present. 4) Limits of detection and quantitation shall be automatically determined by the software if standards have been introduced for the calculation of the response factors even when the standards are introduced through direct air sampling. 5) The software shall have a spectral library which is capable of storing and using new mass spectra for compound identification. Every library match shall come with a value indicating goodness of fit. 6) Software shall allow real time RF scans in quadrupoles and synchronous scans in the first and third quadrupole to perform parent ion scans or neutral loss scans. 7) All operating parameters for the GC, LC, DIP, and the mass spectrometer shall be displayed and stored along with the data file. 8) The software (when the GC or LC is attached) shall be able to reconstruct ion chromatograms and shall allow quantitation using peak height as well as peak area and internal standards. E) The triple quadrupole mass spectrometer vendor will provide the following ancillary equipment: 1) Two extra DB-5 gas chromatography columns 60 meter long 0.25 mm inner diameter and 0.25 ?m coating thickness. 2) Nitrogen gas generator is needed to provide nitrogen for the nebulizing and drying gas in the APCI source. The generator should be a membrane device. The nitrogen must have a purity greater than 99% and be less than 1 % oxygen and 10 ppm organic content. 3) A compressed air gas supply which can provide the flow needed for the nebulizing gas for negative electrospray ionization. 4) Diaphragm vacuum pump 5) A mass flow meter and controller for air flows ranging from 0.5 to 100 ml/min of air. 6) A one year consumables kit. F) Warranty Requirements The fore mentioned system shall be covered by at least a one year warranty covering all parts and labor (at the cost of the vendor). The vendor must have a supply of spare parts available for use and the amount of stocked parts should be based on their past experiences with the instrument. A technical contact should be available for consultation within a day of the initial contact and onsite support should be available within 2 days. G) Documentation Requirements A manual shall be provided with 2 sections (or 2 separate manuals). One section should contain instructions on routine operation (which includes instructions on regular maintenance of the instrument and troubleshooting of the instrument). The other section shall contain instructions on the operation of the software and how to do the data acquisition. H) Operator Training Requirements After the system has been installed and accepted, the vendor will provide at least 5 days of training at the US EPA Research Triangle Park facility. The following topics shall be covered in the training: instrument startup and shut down procedures, verification of proper instrument operation, theory behind operation of the GC, LC, DIP, and mass spectrometer, data acquisition and reduction operations, and maintenance and troubleshooting. I) Installation and Acceptance Test Requirements 1) Once installation is complete the instrument will be tested with a variety of compounds using different configurations for the front end and ionization modes. The conditions of the triple quadrupole mass spectrometer and the definition for the limit of detection can be found in section A) 6 above. The ionization source, the front end configuration, the type of ionization, the ion pairs, and the limit of detection that must be achieved for the compounds is listed in Table 1. These limits of detection must be achieved within 90 days of delivery. Table 1: The conditions for the detection limit acceptance tests. Compound Front end Ionization source Ion Pair Balance Gas or Liquid Composition Limit of detection - ppbv or ng/mL acetone* None -direct air inlet Low pressure chemical ionization 58/58 20% oxygen - 80 % nitrogen 1 ppbv acetone* GC Low pressure chemical ionization 58/58 20% oxygen - 80 % nitrogen 1 ppbv benzene* None -direct air inlet Low pressure chemical ionization 78/52, 78/39 20% oxygen - 80 % nitrogen 1 ppbv benzene* GC Low pressure chemical ionization 78/52, 78/39 20% oxygen - 80 % nitrogen 1 ppbv carbon tetrachloride* GC Low pressure chemical ionization 152/35, 160/37, 156/35, 156/37 etc. 20% oxygen - 80 % nitrogen 1 ppbv chloroform* GC Low pressure chemical ionization 117/35, 119/35, 119/37 20% oxygen - 80 % nitrogen 1 ppbv 1,1,2,2-tetrachloroethane* None -direct air inlet Low pressure chemical ionization 83/83, 85/85 20% oxygen - 80 % nitrogen 1 ppbv 1,1,2,2-tetrachloroethane* GC Low pressure chemical ionization 83/83, 85/85 20% oxygen - 80 % nitrogen 1 ppbv toluene* None -direct air inlet Low pressure chemical ionization 92/39, 92/51 20% oxygen - 80 % nitrogen 2 ppbv toluene* GC Low pressure chemical ionization 92/39, 92/51 20% oxygen - 80 % nitrogen 2 ppbv trans-1,2-chloroethane* None -direct air inlet Low pressure chemical ionization 96/61, 98/61 20% oxygen - 80 % nitrogen 2 ppbv trans-1,2-chloroethane* GC Low pressure chemical ionization 96/61, 98/61 20% oxygen - 80 % nitrogen 2 ppbv trichloroethane* None -direct air inlet Low pressure chemical ionization 130/65, 130/95 20% oxygen - 80 % nitrogen 1 ppbv trichloroethane* GC Low pressure chemical ionization 130/65, 130/95 20% oxygen - 80 % nitrogen 1 ppbv vinyl chloride* None -direct air inlet Low pressure chemical ionization 62/27, 64/27 20% oxygen - 80 % nitrogen 1 ppbv vinyl chloride* GC Low pressure chemical ionization 62/27, 64/27 20% oxygen - 80 % nitrogen 1 ppbv acetic acid None - direct air inlet Atmospheric pressure chemical ionization (- ion mode) 59/59 20% oxygen - 80 % nitrogen 1 ppbv butyl acrylate None - direct air inlet Atmospheric pressure chemical ionization (+ ion mode) 129/73 20% oxygen - 80 % nitrogen 1 ppbv chlorine None - direct air inlet Atmospheric pressure chemical ionization (+ ion mode) 70/35, 72/35, 72/37, 74/37 20% oxygen - 80 % nitrogen 150 pptv chlorine dioxide None - direct air inlet Atmospheric pressure chemical ionization(+ ion mode) 67/35, 69/37 20% oxygen - 80 % nitrogen 23 pptv malathion LC Atmospheric pressure chemical ionization(+ ion mode) 331/285, 331/127 methanol 36 ng/mL Parathion-ethyl LC Atmospheric pressure chemical ionization(- ion mode) 291/262, 291/169, 291/138 methanol 6 ng/mL * Compound found in TO-15 gas standard - detection limits for these compounds can all be found using this single standard ? method can be found in "Analysis of Organophosphorous Pesticides in Honeybee by Liquid Chromatography - Atmospheric Pressure Chemical Ionization - Mass Spectrometry" J. Agric. Food Chem. 2001, 49, 3540-3547. 2) For all the compounds listed in Table 1 (at the conditions also listed in Table 1) a linear range of greater than 5? 105 and dynamic range 5 ?106 must be achieved. 3) For toluene, acetic acid, and butyl acrylate (at their corresponding conditions listed in Table 1) the ion pair signal must vary less than ?20 % over an 8 hour period. 4) The operation of the GC, LC, DIP, and tandem quadrupole mass spectrometer, the data acquisition, and data reduction programs will be tested to make sure that all the various components functioning properly. The software programs must operate the various components and must perform all qualitative and quantitative functions correctly and automatically. This is a combined synopsis/request for quote for a Commercial Items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only RFQ/quotes are being requested and a written RFQ will not be issued. The identifying number is RFQ-OH-06-00174. The RFQ and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 05-09. The NAICS code is 334516. A firm fixed price purchase order is anticipated to result from the award of this RFQ. This US EPA Office of Research and Development has a requirement for a triple quadrupole Mass Spectrometer. Procurement Specifications for the Triple Quadrupole Mass Spectrometer I. Triple Quadrupole Mass Spectrometer Specifications A) A triple quadrupole mass spectrometer that is able to measure fumigants such as chlorine dioxide and vaporous hydrogen peroxide, fumigant generation byproducts such as chlorine (Cl2), 1-chloro-2-propanone, 1,1-dichloro-2-propanone, methyldichloroacetate, chloroform, carbon tetrachloride, acetone, formaldehyde, acetaldehyde, benzaldehyde, and other decontamination products. The mass spectrometer must be equipped with a low pressure chemical ionization source and an atmospheric pressure chemical ionization (APCI) source and both sources must use direct air sampling inlet. Each of the following specifications must also be met: 1) The sample inlet must be able to maintain the specified reduced pressure (see item 2) for the ionization source. 2) The pressure in the low pressure chemical ionization chamber shall be able to be adjusted from 0-10 torr ?0.01torr. 3) The system must have in-line pressure gauges for both ionization sources and for the mass spectrometer. The gauge on the low pressure source must be able to measure pressure from 1-10 torr ? 0.001 torr. 4) A townsend discharge shall be the ion generation method in the low pressure chemical ionization chamber. 5) The mass filters in the first and third quadrupole must have range from 10-1500 amu. 6) The process of switching the ionization source must take less than 1.5 hours and the resulting system pump down must take less than 12 hours. 7) Detection limits are defined as 3 times the standard deviation of the parent/daughter ion pair signal in a purified air or solvent blank divided by the response factor (the slope of the calibration curve for the compound) that was determined using a standard in a balance of the same air blank. The limits of detection for the compounds listed above, specifically the organic compounds (in the vapor phase), must be in the 10 ppb volume range in air using either the APCI or LPCI ionization source. For these determinations the most sensitive ion pairs shall be viewed in selected ion mode. These limit of detections shall be achieved under the following mass spectrometer conditions: " 100 ms dwell time " 10 ms rest time " 0.5 amu widths at half height with Gaussian peak shape for both quadrupole 1 and 3 when they are used at the same time " Argon gas as the collision gas in quadrupole 2 (the collision chamber) 7) The linear range for these compounds shall be 5?105 and the dynamic range for these compounds shall be 5?106. 8) The APCI source must be easily interfaced with the Liquid Chromatograph (LC) and be capable of operating as a traditional electrospray source. The LPCI source must be easily interfaced to a Gas Chromatograph. 9) The mass spectrometer (including one ionization source) must be smaller than 29" deep. 10) The instrument must be listed and labeled by a third party listing agency approved by the North Carolina Building Code Council. Additionally prior to shipping unlisted equipment to the EPA, a field inspection performed by an approved agency (see attachment). The field inspection shall be performed at the manufacturer's place of business and shall be included in the vendor's quotation. If the equipment fails the field inspection, the vendor shall make necessary changes to meet the listing agency's approval B) A gas chromatograph (GC), liquid chromatograph (LC), and direct insertion probe (DIP) must also come with the mass spectrometer and should meet the following specifications: 1) The GC shall have a split/splitless injector. The oven of the GC shall be able to ramp at rates ranging from 1?C in 10 minutes to 50 ?C in 10 minutes and the oven shall be able to reach to 350 ?C. 2) The user shall be able to automatically adjust solvent gradients for the LC and the LC must also include a syringe pump for injections onto the column. 3) A direct insertion probe must also be included for the analysis of solids C) Computer Hardware and Software 1) The PC Workstation at a minimum should have: 3.4 GHz processor speed, 1 GB RAM, 160 GB hard drive, 12x-CD-RW, 3 USB ports, and integrated Ethernet. 2) All parameters of GC, LC, ionization sources, and mass spectrometer must be controlled by the software. 3) Filament delay, tuning of the mass spectrometer, and the ionization process should also be controlled by the software. 4) The software must be section 508C compliant. D) Data Handling- The data handling system shall be capable of the following
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