SOURCES SOUGHT
A -- Management of Information Resources on Therapeutic Agents for HIV And Opportunistic Infections
- Notice Date
- 7/28/2006
- Notice Type
- Sources Sought
- NAICS
- 518210
— Data Processing, Hosting, and Related Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions 6700 B Rockledge Room 3214 MSC7612, Bethesda, MD, 20892-7612
- ZIP Code
- 20892-7612
- Solicitation Number
- RFP-NIH-NIAID-DAIDS-07-27
- Response Due
- 8/11/2006
- Archive Date
- 9/30/2006
- Description
- THIS NOTICE IS FOR INFORMATION AND PLANNING PURPOSES ONLY AND DOES NOT COMMIT THE GOVERNMENT TO AWARD A CONTRACT NOW OR IN THE FUTURE. THIS IS NOT A REQUEST FOR PROPOSALS. THE GOVERNMETN DOES NOT INTEND TO AWARD A CONTRACT BASED ON RESPONSES UNDER THIS ANNOUNCEMENT. ANY PROPRIETARY INFORMATION SHOULD BE SO MARKED. INTERESTED ORGANIZATIONS PRESENTING A CAPABILITY STATEMENT IN RESPONSE TO THIS SOURCES SOUGHT ANNOUNCEMENT MUST IDENTIFY THEIR SIZE STATUS. BASED ON CAPABILITY STATEMENTS RECEIVED FROM THIS ANNOUNCEMENT THIS ACQUISITION MAY BE SOLICITED AS A 100% SMALL BUSINESS SET-ASIDE OR AS FULL AND OPEN. ALL SMALL BUSINESS ORGANIZATIONS (SB, SDB, WOSB, HUBZone, VOSB, and SDVOSB) ARE ENCOURAGED TO RESPOND TO THIS NOTICE. SMALL BUSINESS ORGANIZATIONS MUST HAVE THEIR SIZE STATUS CERTIFIED BY THE SMALL BUSINESS ADMINISTRATION. THE NAICS CODE IS 518210 WITH A SIZE STANDARD OF $23.0 MILLION. This solicitation provides for the management of chemical and biological databases which serve as tools for the rational selection and discovery of potential therapies for AIDS and opportunistic infections (OIs). The Contractor shall update the databases with pertinent published literature and NIAID confidential data and information on the chemical, virological, immunological and microbiological aspects of therapeutic agents for HIV, OIs, and TB, and on microbicides. The chemical and biological databases which the Contractor shall maintain and update are incorporated into a master database and are described as follows: 1) Anti-HIV Therapeutic Agents Database ? contains in vitro inhibitory and enzyme mechanistic data from the public literature linked to over 99,529 compounds; 2) Co-infections Database ? contains data from the public literature on OI therapeutics, data on tuberculosis-associated agents, and data containing propriety information on more than 108,459 investigational compounds; 3) M. tuberculosis Database ? contains data on over 94,386 compounds tested for activity against M. tuberculosis; 4) Topical Microbicides Database? contains experimental data on over 1,645 topical agents tested against the spread of HIV; 5) Literature Citations Database ? contains over 14,634 references from published literature, patents, and meeting abstracts that can be searched by author, title, journal, patent number or year of publication, and that are linked to Medline abstracts in the PubMed database; and 6) Publicly Available Web Database ? located at http://chemdb.niaid.nih.gov, contains non-confidential portions of the master database. Currently, there are over 138,703 compounds linked to over 2,908,104 lines of data on this public website. In addition to the chemical and biologic data, the public website contains links to bi-weekly Literature Surveillance Memos that identify relevant published research on pre-clinical experimental therapies for HIV, OIs, and other viral pathogens. The scope of information resource management activities to be performed by the Contractor include literature surveillance on experimental therapeutic agents for HIV and OIs, abstraction of pertinent data and updating of the chemical and biologic databases, maintenance and updating of the literature citations and publicly available Web databases, maintenance of the computer systems and provisions for quality control. The Contractor shall exercise considerable professional judgment in surveying a broad base of literature sources and in selecting citations that contain information pertinent to HIV and OI preclinical therapeutic and drug discovery efforts. The sources of data for updating the databases are as follows: 1) Public literature (including publications, patents and meeting abstracts); and 2) HIV and OI infections data reports supplied by DAIDS-supported screening contractors performing in vitro and in vivo biological assays. The reports will be provided to the contractor by the Project Officer. Potential sources must demonstrate and document their experience and ability to perform the following in their capability statements: 1) relevant experience in literature surveillance, in data retrieval, computerized database management and competency in computer science aspects of the database software/hardware, in particular MDL IsisBase/IsisHost and Oracle software; 2) experience and knowledge of the basic biology of HIV and OIs and their therapies; 3) senior staff with adequate experience and qualifications to manage multiple projects simultaneously; 4) facilities, equipment, and resources that are adequate, suitable, and immediately available for the conduct of the database management activities; 5) willingness to prioritize Government projects within the organization's overall scheduling framework; and 6) the ability to maintain confidentiality of data. The Government estimates an overall staffing requirement of approximately six (6) full time equivalents (FTEs) per year for a period of seven (7) years for this effort. Interested Small Business organizations should submit two (2) copies of their capability statement addressing each of the areas cited above. Written capability statements should be received by the NIAID Contracting Officer at 3:30 PM Eastern time by August 11, 2006. Please reference the solicitation number on all related correspondence. No collect calls will be accepted. No facsimile transmissions will be accepted. Point of Contact Jill M. Johnson, Contracting Officer, Phone 301-451-6396, Fax 301-402-0972, Email JMJohnson@niaid.nih.gov Eileen Webster-Cissel, Contracting Officer, Phone 301-496-0612, Fax 301-480-5253, Email ew52c@nih.gov
- Record
- SN01100360-W 20060730/060728220414 (fbodaily.com)
- Source
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