SOLICITATION NOTICE
H -- AQUA analysis of breast cancer in the Polish Case-Control Study
- Notice Date
- 8/11/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- Reference-Number-NCI-60144-NV
- Response Due
- 8/28/2006
- Archive Date
- 9/12/2006
- Description
- In accordance with Simplified Acquisition Procedures the National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Genetic Epidemiology Branch (GEB), intends to procure on a sole-source basis with Yale University School of Medicine, 310 Cedar Street, PO box 208023, New Haven, CT 06520 to perform Automated Quantitative Analysis (AQUA) of immunofluorescent stains performed on tissue microarrays (TMAs) of invasive breast tumors collected from the DCEG?s population-based case-control study in Poland to investigate the etiology of breast cancer. Tissue Microarray (TMA) technique, which permits the analysis of hundreds of tissue samples simultaneously using just a few slides, is ideally suited for epidemiological studies and Yale University has built TMAs for 1761 (842 cases in TMA1 and 919 cases in TMA2) invasive breast cancer tissues collected in the Polish case-control study. The first set of TMAs (TMA1) has been stained for four markers (ER-, ER-, PR and HER2) using Automated Quantitative Analysis (AQUA?) analyses. This work demonstrated AQUA analyses of tumors represented in TMAs provide reliable, quantitative measures of immunofluorescent, which can be used to advance research on differences in cancer etiology based on stratification of tumors by marker expression. In a continuation of an on-going study Yale University School of Medicine shall: 1) Perform AQUA analysis of TMA1 containing tissue samples from 842 Polish breast cancers with two-fold redundancy (i.e. 1,684 cores) for EGFR; and 2) Perform AQUA analysis of TMA2 containing tissue samples from 919 cases with three-fold redundancy (i.e. 2,757 cores) for ER-, PR, HER2, and EGFR. These activities are required in order to: 1) identify molecular subtypes of breast cancer; 2) evaluate associations between tumor subtypes defined by marker expression and risk factors for breast cancer; and 3) evaluate associations between tumor subtypes defined by marker expression and survival and prognosis of breast cancer patients.Yale University is the only vendor known to the NCI Researcher that can perform the required AQUA analysis without the introduction of new variables in on-going research. This is not a solicitation for competitive quotations. However, if any interested party believes it can provide the above service, without introducing new variables into an ongoing research experiments it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. An original and one copy of the capability statements must be received in the contracting office by 1:00 p.m. EDT, on August 28, 2006. Faxed and emailed capability statements are NOT authorized. All questions must be in writing and can be faxed to (301) 402-4513 or emailed to dm170b@nih.gov. It is the vendor's responsibility to call (301) 402-4509 to verify questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award from the NCI contractors must be registered in the Online Representations and Certifications Applications (ORCA). Please refer to http://orca.bpn.gov in order to register. In addition, contractors must be registered in the Central Contractor Registration (CCR) www.ccr.gov. No collect calls will be accepted. NAICS 541380, Size Standard $6.5M.
- Record
- SN01112571-W 20060813/060811220551 (fbodaily.com)
- Source
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