SOLICITATION NOTICE
L -- ANALYSIS OF NIH DIT TOOLKIT
- Notice Date
- 8/16/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Nat'l Institute of Diabetes, Digestive, & Kidney Diseases, 2 Democracy Plaza, Suite 700W 6707 Democracy Blvd., MSC 5455, Bethesda, MD, 20892-5455
- ZIP Code
- 20892-5455
- Solicitation Number
- NIH-NIDDK-06-993
- Response Due
- 9/11/2006
- Archive Date
- 9/26/2006
- Description
- The National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) has a requirement to purchase the services of the Research Systems Inc., 4990 Pearl E Circle, Boulder, CO 80301 to perform analysis of NIH DIT Toolkit. Several NIH Institutes have jointly sponsored a large multicenter study of normal brain development in children. The goal of this study is to learn more about how the brain develops in typical, healthy children and adolescents. This study will enroll approximately 500 children, ranging from infancy to young adulthood, who will be seen at different time points over a six-year period. Magnetic Resonance Imaging (MRI) of the brain will be performed and the imaging findings will be related to the results of standardized neuropsychological tests. A Diffusion Tensor MRI processing Center (DPC) was established in the Section on Tissue Biophysics and Biomimetics (STBB), LIMB, NICHD to process and analyze diffusion tensor MRI (DT-MRI) data that will be acquired by the various Centers during the course of the study. We have developed software to accomplish these tasks. Our software, which we will refer to as the NIH DTI toolkit, is primarily written in IDL, although it performs external calls to procedures written in C, and Java. The program also calls other executables routines, such as the BET procedure developed by the FSL group in Oxford, UK. The NIH DTI toolkit receives as input Diffusion Weighted Images (DWIs) in DICOM format and produces as output Diffusion Diffusion Tensor derived quantities in Analyze format. The diffusion tensor MRI data processing pipeline consists of these main steps: 1) Importing raw data and sorting correctly the b-matrices; 2) Performing motion and eddy-current distortion correction; 3) Registering raw images to a template; 4) Producing new b-matrices taking into account eventual rotation of coordinate system; 5) Producing ?corrected? raw images re-samples at an arbitrary resolution; 6) Computing the diffusion tensor via multivariate non-linear regression with robust estimation; 7) Computing tensor derived variables such as Trace(D), Fractional Anisotropy, Directionally encoded Color Maps, etc.. One important next step of our work is to release our NIH DIT toolkit to the scientific community enabling investigators outside our group to process their own data in accordance with our data processing protocols. In order to achieve this goal we need to accomplish the following tasks: 1) Streamline the current code by removing spurious procedures that are not relevant to the functionality of the program; 2) Optimize procedures for improved performance; 3) Add comments to the code. To the best of the Governments knowledge the proposed contractor is the only known source that can provide the services as described above. Interested vendors may identify in writing their interest with a capability statement to the Contracting Office prior to the closing date of this notice. This notice of intent is not a request for competitive proposals, however, all responses received, before the closing date of this announcement, will be considered by the Government. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. It is anticipated that the Request for Quotation (RFQ) NIH-NIDDK-06-932 will be available fifteen (15) days after the release of the RFQ. Receipt of quotations will be due ten (10) days after the release of the RFQ. The anticipated award date is September 11, 2006. Request for copies of the RFQ must be in writing to the National Institutes of Diabetes and Digestive and Kidney Diseases, 6707 Democracy Blvd., Room 774C, Bethesda, MD 20817 ttention: V. Lynn Griffin. FAX quotations must contain offerors name, address, telephone number and fax number. FAX quotations will be accepted if dated and signed by an authorized company representative. FAX NUMBER 301-480-8501.
- Record
- SN01116497-W 20060818/060816220545 (fbodaily.com)
- Source
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