SOLICITATION NOTICE
A -- AGE RELATED INTRAHUMAN VARIABILITY IN INHALATION DOSIMETRY
- Notice Date
- 8/23/2006
- Notice Type
- Solicitation Notice
- Contracting Office
- Environmental Protection Agency, Ord Service Center, 26 West Martin Luther King Drive, Cincinnati, OH 45268
- ZIP Code
- 45268
- Solicitation Number
- RFQ-OH-06-00221
- Response Due
- 9/7/2006
- Archive Date
- 10/7/2006
- Description
- NAICS Code: 541710 The US Environmental Protection Agency (EPA), Office of Research and Development (ORD), National Center for Environmental Assessment (NCEA) intends to negotiate, on a sole source basis, under the authority of FAR 13.106-1(b), with Dr Julie Kimball with CIIT to develop and use anatomically accurate inspired air flow models of children and pre-adolescent human nasal tract regions, to evaluate the influence of age-related anatomy on inhalation dosimetry. The current NAICS code is 541710. Based on the EPA's knowledge of the Technical Support needed for the Statement of Work (SOW) there may be unique capabilities to particular contractors/consultants. Background The Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA-RTP) is currently developing methodologies and information sources for use in developing and advancing the practice of inhalation dosimetry utilized to evaluate effects from inhaled agents. Overall, this project is being proposed as a means to advance the science that may be utilized in making estimates of safe exposures under inhalation exposure scenarios. Specifically, this project would yield information on intraspecies (human-to-human) variability among children and preadolescents that may be applied to this area of uncertainty common all health risk assessments performed by EPA. The current EPA default procedures for dosimetry of gases to the upper airways tract utilizes a ratio of the principal factors of ventilation volume and surface area of the affected area of the respiratory tract. In this default form, these factors combine to give a theoretical estimate of dose to the affected area of the respiratory tract that would be the totality of the gas present in the air breathed impinging on the totality of the affected area or VE / SART. Further, the current EPA default assumes that impingement on the surface area occurs in a uniform manner such that every unit of the surface area is exposed to the same amount of air and gas present in that air. General Task Description Dr. Kimbell's more recent work has been to prepare highly individualized rather than representative maps of internal tract anatomy for several human subjects. The individualized maps are of sufficient resolution to reflect intra-human differences in nasal tract anatomy. CFD simulations of these individualized models would be expected to predict and elucidate intra-human differences in flux to the underlying tissues. Further, the pattern of flux may show differences based on the extent of the gas extraction of the individual gas from the inspired air. Therefore this project provides for generating the flux estimates using these individual models under different extents of gas extraction and to put forth proposals as to how the differences observed may be characterized. As each spectra of flux will appear as a continuous spectrum, various means for providing a more discrete description will be attempted which include, but is not limited to investigate the sorting of various intensities of flux into "bins". This "binning" or some similar process may be used to more quantitatively describe any predicted intra-human differences. These predicted intra-human differences would then be compared with and used to inform and characterize the current EPA default VE / SART for this area of the respiratory tract. The deliverables from this specific project will be the second installment, the first having been completed under a previous EPA Purchase Order. However, any firm believing itself capable of meeting the EPA's requirement may submit technical documentation to establish the potential of complying with the specifications. Such documentation must be submitted to the point of contact within 15 days of the posting of this notice. A determination not to compete the proposed requirement, based upon responses to this notice, is solely within the discretion of the Government. Information received will normally be considered only for the purpose of determining whether to conduct a competitive procurement or to proceed on a sole source basis. The applicable NAICS code is 541710. Please submit your request in writing to Scott A. Fogle at fogle.scott@epa.gov or fax your request to (513) 487-2107. No telephone requests will be honored.
- Record
- SN01123892-W 20060825/060823222047 (fbodaily.com)
- Source
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