SOLICITATION NOTICE
A -- Melanoma Progression Tissue Microarray to Support Marker Development
- Notice Date
- 9/1/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- Reference-Number-NCI-60179-NV
- Response Due
- 9/15/2006
- Archive Date
- 9/30/2006
- Description
- In accordance with Simplified Acquisition procedures The National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Cancer Treatment and Diagnosis (DCTD), Cancer Diagnosis Program (CDP) intends to procure on a sole-source basis with the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 671 Hoes Lane, Piscataway, NJ 08854 to construct the melanoma tissue microarray (TMA) to support marker development to improve diagnosis, prognosis and for the evaluation of response predictive markers. The Robert Wood Johnson Medical School has an unique sets of melanoma specimens with complete patologic and clinical data available. They have identified cases with matched melanoma samples representing different stages of melanoma progression from the same patient and they have clinical outcome data on all patients with median follow-up of 5.5 years. These tissue arrays will allow investigators to examine melanoma progression in individual patients and compare primary tumors, regional dermal metastases, nodal metastases, and distant metastases. They have also gathered specimens from patients with thick primary lesions who developed metastatic disease. Primary melanoma arrays are very difficult to produce because of the small sample size. Therefore, the thick melanoma specimens will provide adequate material for constructing TMAs. Furthermore, each sample included in the array will be identified with respect to B-RAF and N-RAS oncogene mutational status, which would be a unique feature of the TMA. The state-of-art core facilities at the Robert Wood Johnson Medical School and the expertise of the investigators provide assurance that the project of generating the progression melanoma TMA will be successfully completed. Their facilities and services include: 1) Tissue Analytical Services (TAS) that have three components: a Tissue Retrieval Service, immunohistochemistry (IHC) Core Facility, and a TMA construction Core Facility. The personnel of the TMA Core Facility will supply the newest equipment to construct array from the supplied tissue and will provide the expertise to produce high quality array; 2) The Division of Biometrics will provide help with optimization of the design of the array; 3) The system that allows automated registration of arrays, high resolution digital imaging of each core, and archiving of the images is available at the institution. The system has also capacity for unsupervised computer-based analysis of immunostained arrays to identify staining signatures of specimens in multidimensional color space; and 4) the image archive will be linked to the anonymized clinical database to correlate the TMA findings with pathology and clinical outcome measures. The investigators are in the process of developing bar code-based storage and retrieval system that will catalog tissues in a HIPPA-compliant fashion. The investigators at Robert Wood Johnson Medical School are the only known source to the NCI Researcher that has the facilities, samples and expertise required to develop these melanoma tissue microarrays. This is not a solicitation for competitive quotations. However, if any interested party believes it can meet the entire above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI researcher to determine if it can meet the requirements of this synopsis. An original and one copy of the capability statements must be received in the Contracting Office by 1PM EDT (local Washington, D.C. time) on September 15, 2006. Faxed and emailed capability statements are NOT authorized. All questions must be in writing and may be emailed to Debbie Moore at dm170b@nih.gov or faxed (301) 402-4513. It is the vendor?s responsibility to call (301) 402-4509 and verify that questions were received. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award from the NCI contractors must be registered in the Online Representations and Certifications Applications (ORCA). Please refer to http://orca.bpn.gov in order to register. In addition, contractors must be registered in the Central Contractor Registration (CCR) www.ccr.gov. No collect calls will be accepted. NAICS: 541990; Size Standard is $6.5 million.
- Record
- SN01132499-W 20060903/060901220546 (fbodaily.com)
- Source
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