SOLICITATION NOTICE
W -- VISUALSONICS IN-VIVO MACHINE - LEASED
- Notice Date
- 11/1/2006
- Notice Type
- Solicitation Notice
- NAICS
- 532490
— Other Commercial and Industrial Machinery and Equipment Rental and Leasing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Nat'l Institute of Diabetes, Digestive, & Kidney Diseases, 2 Democracy Plaza, Suite 700W 6707 Democracy Blvd., MSC 5455, Bethesda, MD, 20892-5455, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- NIH-NIDDK-07-045
- Response Due
- 11/27/2006
- Archive Date
- 12/12/2006
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIH-NIDDK-07-045 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2001-27. The North American Industry Classification (NAICS) Code is 334516 and the business size standard is 500 employees. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. However, this solicitation is not set aside for small business. It is the intent of the National Institutes of Health (NIH); National Institute on Alcohol Abuse and Alcoholism (NIAAA) to procure FROM JTA Leasing Co LLC, 2050 Center Avenue, Suite 600, Fort Lee, NJ 07024 a Master Lease Agreement for: VEVO 770 High-Resolution in Vivo Imaging System (120V), RMV 707B ?High? Frame Rate? ScanHead, RMV 716 ScanHead, Pulsed Wave Doppler, M-Mode Capture and Analysis Software, Advanced Cardiovascular Package, Additional VEVO 770 Software Site Licenses, VEVO Integrated Rail System III, Mouse Handling Platform II, RAT Handling Platform II, VEVO Compact Anesthesia System (Mobile Version), ?E? Type Regulator, Image Starter Kit, Image-Guided Injection Starter Kit and Introductory 2-day On-Site user Training Session. Anatomical, Functional (Flow), Physiological and molecular Data available from the Same Platform in Real-Time: The Vevo 770 allows the researcher to derive anatomical, function (or blood flow), physiological and molecular data (using contrast agents) from the same platform in real time and non-invasively for longitudinal studies of small animals and in vivo. Size of Required Detection: The Vevo 770 non-invasive high-resolution imaging system is designed specifically for small animal imaging and can detect anatomical and physiological structures and hemodynamics with a spatial resolution down to 30 microns in real-time. Frequency: The Vevo 770 provides imaging with frequencies up to 82.5 MHz as opposed to maximum frequencies of 15 MHZ provided by conventional clinical ultrasound machines. Encapsulation of Scanhead: The Vevo 770 system is a high-resolution micro-imaging system using ultrasound that has an encapsulated probe (orscanhead) to reduce movement during the procedure of the subject being studied. Rapid Screening Ability of Scanhead: VSI probes RMVTM Scanheads) are both hand held and mountable on an integrated Rail System allowing the researcher an excellent tool for rapid screening of mice and rats (ie, embryonic screening, mutant detection, verification and dating of pregnancy, confirmation of tumor growth, etc.). Multiple Scanheads Available: Eight scanheads are available to provide the appropriate image results for specific small animal research applications. These scanheads (RMVTM Scanheads) allow resolution down to 30 microns at varying depths of penetration and are designed specifically for small animal imaging. Data Export: Data export is required for ongoing data analysis. VSI allows easy data export and analysis of the imaging session data. Measurements and calculations can be exported into MS ExcelTM spreadsheets and images can be exported as, TIFF or BMP (static images) or as Windows, AVI or Quicktime files (up to 300-frame cine loops). Experiment-based Data Management: Large numbers of data sets on multiple experiments on multiple animals require the imaging systems to facilitate an experiment-based approach to data analysis (as compared to a patient-based data orientation with clinical-imaging systems). Typically, multiple researchers will perform measurements on the same animal and a single study will include multiple animals studies over multiple time-points. The Vevo 770 software is designed in this manner and facilitates easy analysis and aggregation of multiple results. The Vevo Study Manager Is the Interface to this research-oriented software tool. In addition, unlike clinical systems which only allow a single set of measurements to be made on a particular image (for reasons of clinical diagnostics), the Vevo allows multiple researchers to make multiple instances of the same dClta and image and therefore measure and re-measure the same image. High Frame Rate for Real-Time Visualization. The basis of small animal imaging requires a frame rate sufficiently high so as to provide images in real time. The VSI system has a frame rate of 100 Hz+ (in B-Mode) which allows for real-time visualization and data capture. Frame rates up to 240 Hz are achievable in sectored mode with specific cardiovascular RMV scanhead models while maintaining high line densities and image Quality. A frame rate of 1,000 frames/second is available in M-Mode and PW Doppler Mode. VSI also has a cardiac application called EKVTM (ECG-based Kilohertz Reconstruction) that provides line-based reconstructed visualization and measurement of the beating adult mouse heart at up to 1,000 frames/second. Needle-guided injection/extraction system. Due to very small size of the sma11 animal subjects and the requirement to visualize and guide injection, procedures, researchers require the ability to ensure the accurate and successful injection and extraction of "products" (cells, genetic materials) into the target areas of their animals in vivo. The VSI image-guided needle injection/extraction system was designed specifically for this application and is integrated into the core Vevo 770 imaging system. The injection apparatus includes the option of a micro-injection unit as well as the ability to incorporate conventional syringes (ie. for adult mouse cardiac injection procedures). Dedicated Mouse/Rat-Handling and Physiological Monitoring Apparatus: In order to streamline the workflow involved with imaging a small animal and ensure optimal image results, it is critical that the imaging system is quickly brought into alignment of the area of focus and that the anesthetized mouse/rat is quickly and easily manipulated for optimal imaging. The VSI rail-mounted small animal handling and monitoring apparatus is a bench-mounted adjustable rail system that is custom designed for small animal handling, positioning and physiological monitoring. The system includes a resistor-based heating system to ensure that the comfort of the mouse while anesthetized is maximized and that the environment during the imaging session closely reflects normal physiological activity. The table also has ECG pads that allow ECG to be captured and displayed on-screen in all three imaging modes. Integrated Blood Pressure with High-Resolution Micro-Imaging: The Vevo 770 allows integrated blood pressure analysis functionality (ie. the integration of a blood pressure signal from a third-party continuous pressure monitoring system). Examples include integration with conductance catheter and telemetry blood pressure monitoring. The integrated blood pressure can be combined with the Vevo ultrasound Image data and corresponding measurements to perform small animal pressure-volume and vascular strain analysis. Real time imaging: Real time imaging allows for greater accuracy of needle-?guided injection/extraction, more precise focus of study, efficient use of lab time, and rapid completion of study given the limited time frame allowed for a small animal being studied to be under anesthesia. It is also critical for cardiac and flow studies or evaluation of dynamic targets. The VSI Vevo 770 provides such real time visualization and phenotyping functionality. Relative visualization and quantification of blood flow in tumors: The Vevo 770 high-resolution Imaging system can visualize and quantify tumors in soft tissue in subcutaneous targets as well as orthotopically. With Power Doppler, slow-flowing vasculature in target tumors can be detected and a relative flow measure is applied. With 3D Power Doppler, CI 30 volumetric measurement of the tumor plus a 3D image of the now and flow architecture is provided along with a "PV? or Percent Vascularity Index for quantification of tumor flow within the defined tumor area. As such, tumor growth and flow can be visualized and monitored longitudinally. No special room with shielding required: With the VisualSonics ultrasound-?based product, there are no radioactive substances used, and unlike other imaging modalities, no dedicated room or special room shielding is required. Portability of system: The VSI system is portable and can be moved by operators with relative ease from one room or lab to another or within the animal colony to increase the utilization of the system and to serve the possible needs of multiple labs. Flexibility of applications and techniques: The Vevo 770 has eight different scanheads available at different frequencies to enable imaging of various species and to varying degrees of detail. Its applications include cardiovascular research, neurobiological research, cancer biology, developmental biology, nephrology, etc. The Vevo also has the ability to perform a number of required techniques including screening, needle-guided injections/extractions, tumor identification, characterization and measurement and blood flow analysis. Its basic system also can be upgraded with additional functionality when required which distinguishes it from other systems. Reduced training and expertise. The Vevo 770 high-resolution imaging system can be operated after only modest instruction with relatively brief setup time. Advanced imaging or sonography experience is not a prerequisite for operating the system. In addition, VSI has a comprehensive series of 2-day on-site training programs that can easily be customized to individual research program needs. Extensive Custom And organized Group Training Sessions: VisualSonics offers custom on-site training (application- and customer-specific programming) -as well as pre-set group courses frequently throughout the calendar year involving in vivo training in the licensed Toronto imaging facility. Additional courses are also held In North American in association with The Jackson Laboratory and in Europe with Animage (France). Imaging data storage and retrieval: During imaging, many large data files are created. Therefore a system is needed that is capable of storing and retrieving large amounts of data. The VSI Vevo 770 is equipped with a 120 GB hard drive and an on-board DVD drive sufficient to meet expanding data needs. Network connectivity: Having the capability to move these large data files from the instrument to an institutional network or to collaborating colleagues is critical in the research environment. The VSI product possesses the network connectivity required. Compact system footprint: The VSI Vevo 770's footprint is 28? (width) x 38? (depth) X 59? (height, with monitor and can easily be moved to less congested areas or to other labs requiring use of the system through the use of its large rolling casters. Imaging data stored in multiple formats: Images should be able to be viewed as static (or still) or in a moving or animated state. The Vevo 770 allows for image capture, review and export as static images or as 300-frame, 10-second CineLoop files. PW Doppler files are also available as wav audio files to detect irregularities for flow analysis. Small animal-based measurements and annotations: Once captured, images require extensive and rapid measurement and annotation. The Vevo 770 provides extensive measurements and annotations functionality with over 200 small animal-based predetermined measurements and calculations embedded within the software. All measurements and calculations are exported to MS ExcelTM or a standard spreadsheet to facilitate post-imaging analysis. In addition, all image files can be opened by a second investigator and re-measured and annotated for purposes of validation and verification. Quantification scales are appropriate for small animal research: All measurements and calculations utilize sizes that are appropriate for the anatomical and functional targets on small animals. For example, linear measurements are in grams and mm (as opposed to cm for clinical systems) and milliseconds (as opposed to seconds for clinical systems). Integrated Isoflurane-based anesthesia: The Vevo 770 has an integrated small animal anesthesia system available with the imaging system. Anesthesia hoses are connected to the small animal handling platforms and specific nose pieces are available for mice and rats. Once under anesthesia, mouse body temperature can be monitored through the physiological controller and modified through heated resistors in the mouse platform. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors ? Commercial; 2) FAR Clause 52.212-2, Evaluation ? Commercial Items. As stated in FAR Clause 52.212-2 (a), ?The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered.? The following factors shall be used to evaluate offers: Technical Evaluation, Price, and Past Performance; 3) FAR Clause 52.212-3, Offeror Representations and Certifications ? Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions Required To Implement Statues or Executive Orders ? Commercial Items, Contract Terms and Conditions ? Commercial Items; and 5) FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders ? Commercial Items ? Deviation for Simplified Acquisitions. This notice of intent is not a request for competitive quotations however; all responses received within 15 days from the date of publication of this synopsis will be considered by the Government. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely for the purpose of determining whether to conduct a competitive acquisition. The offeror must include in their quotation, the unit price, the list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.arnet.gov/far. Interested vendors capable of furnishing the government with the item specified in this synopsis should submit their quotation to the below address. Quotations will be due fifteen (15) calendar days from the publication date of this synopsis or November 27, 2006. The quotation must reference ?Solicitation number? NIH-NIDDK-07-045. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Blvd., Room 774B, Bethesda, Maryland 20817, Attention: V. Lynn Griffin. Faxed copies will not be accepted.
- Place of Performance
- Address: BETHESDA, MD
- Zip Code: 20892
- Country: UNITED STATES
- Zip Code: 20892
- Record
- SN01174179-W 20061103/061101220211 (fbodaily.com)
- Source
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