SOLICITATION NOTICE
B -- Analyses of Data from the
- Notice Date
- 3/21/2007
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD, 21224, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- LEDB0717
- Response Due
- 3/30/2007
- Archive Date
- 4/14/2007
- Description
- The National Institute on Aging , IRP, intends to negotiate and award a purchase order on a noncompetitive basis with the Peninsula College of Medicine and Dentistry, University of Exeter for project entitled ?Analyses of Data from the ?Studies of Aging and Genome Wide Associations? (SAGA) ? Phase I. The contractor will conduct extensive quality control checks to filter out poorly performing genotypes. These will include screening out or clearly labeling SNPs with low call rates, departures from Hardy-Weinberg equilibrium, low quality scores and poor duplicate performance. To determine exact criteria for excluding data the contractor will liaise with the NIA Laboratory of Neurogenetics and Illumina. The contractor will prepare a linked database of cleaned genotyping data and baseline InCHIANTI phenotype data. This will include the principal physical performance outcomes, summary disease status measures and potential confounders. The contractor will perform a primary analysis of SNP ? principal phenotype comparisons. An initial screen of statistically significant associations between genotypes and the short physical performance battery score will be undertaken. The contactor will use the ?PLINK? software, as used by the NIA Neurogenetics laboratory, to complete this step. The contractor will perform a primary analysis of SNP ? phenotype comparisons against these markers. NIA staff will collaborate on determining a single summary marker of inflammation as a primary outcome. An initial screen of statistically significant associations between genotypes and the inflammatory and fasting glucose markers will be undertaken. The contractor will use the ?PLINK? software, as used by the NIA Neurogenetics laboratory, to complete this step. Only one responsible source and no other supplies or services will satisfy agency requirements, 41 U.S.C. 253 (c) (1), FAR 6.302-1 (b) (1). The cited authority is applicable because the University of Exeter is the only source that can fulfill the requirements of this contract. The contractor has led an NIA supported candidate gene association study (NIH Grant 5R01AG024233-03) on aging phenotypes, including the utilization of data from the InCHIANTI study. Early results have remarkably good, including discovery of role a CDKN2a (p16/ARF) polymorphism on aging. This finding indicates that physical function markers (gait speed, chair stands and balance in the Short Physical Performance Battery SPPB scores) can be used in InCHIANTI and other studies to fund important polymorphisms. The contractor has also examined polymorphisms in several inflammatory markers, including Interleukin-18, 1 receptor antagonist and 6 receptors. The contractor has also studied the role of the TCF7L2 variant of type 2 diabetes in the InCHIANTI study. The period of performance is 12 months. The North American Industry Classification (NAICS) is 541990 and the size standard is $6.5 million. This acquisition is being conducted under Simplified Acquisition procedures and is exempt from the requirements of FAR, Part 6, Competition Requirement.
- Place of Performance
- Address: Baltimore, MD
- Zip Code: 21224
- Country: UNITED STATES
- Zip Code: 21224
- Record
- SN01255757-W 20070323/070321220439 (fbodaily.com)
- Source
-
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