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FBO DAILY ISSUE OF APRIL 01, 2007 FBO #1952
MODIFICATION

A -- Identification of single Nucleotide Polymorphisms (SNPs) in Disease Susceptibility Genes Re-competition

Notice Date
3/30/2007
 
Notice Type
Modification
 
NAICS
541710 — Research and Development in the Physical, Engineering, and Life Sciences
 
Contracting Office
Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management P.O. Box 12874, 79 T.W. Alexander Dr, Bldg 4401, RTP, NC, 27709, UNITED STATES
 
ZIP Code
00000
 
Solicitation Number
NIH-ES-07-05
 
Response Due
5/31/2007
 
Archive Date
8/1/2007
 
Point of Contact
Tommy Hardee, Contracting Officer, Phone 919-541-0429, Fax 919-541-2712, - Latise Lewis, Procurement Technician, Phone 919-541-7950, Fax 919-541-2712,
 
E-Mail Address
hardee@niehs.nih.gov, lewisl@niehs.nih.gov
 
Description
This announcement is a followup to the Sources Sought announcement published January 25, 2007. The National Institute of Environmental Health Sciences (NIEHS) intends to solicit proposals on a 100% small business set-aside basis as a follow-on to contract N01-ES-15478 awarded to the University of Washington. Contract objectives include 1) establish a catalog of Single Nucleotide Polymorphisms (SNPs) in prioritized environmental response genes (ERGs) based on direct re-sequencing of selected genes; 2) use high-throughput sequencing technologies for rapid sequencing analysis utilizing a national sample repository for analysis of sequence variation in the U.S. population and make this data available to the scientific community via centralized public databases; 3) develop web-based tools to display estimated haplotypes and linkage disequilibrium patterns in human populations using the EGP data sets; 4) evaluate the population distributions of estimated haplotypes and identify evolutionary patterns among the human populations represented in the polymorphism discovery resource samples; and 5) mine the sequence variation in EGP genes to highlight potential functional coding or non-coding variants for further biological testing. Specific performance will involve re-sequencing up to a total of seventy-five (75) gene equivalents (GE) over a four (4) year period from genomic DNA obtained from a sample of ninety-five (95) ethnically defined individuals, data entry and validation. The estimated release date for the solicitation is mid April. The estimated receipt date for proposals is late May. Electronic versions of the RFP will be available at http://www.niehs.nih.gov/oamb/rcb/rfp.htm. All eligible responsible sources may submit a proposal which shall be considered. See notes No. 1. and 26.
 
Record
SN01262892-W 20070401/070330220431 (fbodaily.com)
 
Source
FedBizOpps Link to This Notice
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