SOURCES SOUGHT
A -- Comments Function
- Notice Date
- 6/12/2007
- Notice Type
- Sources Sought
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- NHLBI-HR-08-09
- Archive Date
- 6/30/2008
- Description
- The NHLBI is seeking a small business with the ability to serve as a Radiology Center (RC) for a new six-year multi-center clinical research study entitled, SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). This observational study will collect and analyze phenotypic, biomarker, genetic, genomic, and clinical data from several thousand research subjects with COPD. Baseline data will be analyzed in a cross-sectional manner to identify subpopulations of patients with similar molecular abnormalities. Longitudinal data will be used to identify and validate intermediate outcome measures, such as x-ray computed tomographic (CT) image, biomarker, and genomic measures whose spontaneous changes over a period of 9-12 months correlate with long-term (3 year) outcomes of mortality, frequency of hospitalizations, change in spirometry, and change in quality of life. Secondary aims are to develop a bioinformatic infrastructure that will enable the utilization and sharing of pulmonary research data and to create a collection of clinical, biomarker, radiographic, and genetic data that can be used by external investigators for other studies of COPD. Research subjects will be enrolled, phenotyped, and followed at approximately eight Clinical Centers (CCs) solicited under a separate request for proposals. A Genomics and Informations Center with have primary responsibility for operating a repository of biospecimens; developing bioinformatic resources; designing and implementing a strategy for data collection and analysis to identify subpopulations and intermediate outcome measures which includes molecular phenotypic data obtained with high throughput genetic and genomic assays; training CC staff; managing study data; providing overall management and oversight of the study; and disseminating study results. The Radiology Center will have primary responsibility for: 1) providing expertise in radiology and chest computed tomographic (CT imaging); 2) standardizing imaging methods at the Clinical Center; 3) establishing a repository of CT image data for SPIROMICS; 4) assessing and assuring quality of CT images; and 5) analyzing lung CT images to obtain quantitative measures that may indicate the presence and/or severity of COPD or other lung diseases. The RC must provide expertise in lung image acquisition, processing, and analysis and must have experience in directing lung CT imaging in multi-center clinical research. This is not a request for proposals (RFP) and the Government is not committed to awarding a contract pursuant to this announcement. Small business concerns that believe they possess the capabilities necessary to undertake this study should submit complete documentation of their capabilities to the Contracting Officer at the above noted address. The capabilities statement submitted in response to this synopsis shall include 1) the total number of employees, 2) the professional qualifications and research experience of scientific, medical, and technical personnel in accordance with the above outline requirements, 3) a description of general and specific facilities and equipment available, including computer equipment and software, 4) an outline of previous multi-center research projects in which the small business organization and the proposed personnel have participated, and 5) any other information considered relevant to this program. The capabilities statement must not exceed 8 single sided or 4 double sided pages in length. Interested small business organizations submitting a capability statement are required to identify their size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in response to this RFI. However, responses to this RFI that indicate that the information therein is propriety will be properly safeguarded for Government use only. Questions, concerns and responses should be emailed to Ms. Joanne Deshler at deshlerj@nhlbi.nih.gov. Responses shall be submitted in Adobe Acrobat PDF format by 3p.m. eastern standard time June 27, 2007, and include the name and telephone numbers of a point of contact having authority and knowledge to discuss responses with Government representatives. When submitting this information, please reference the solicitation notice number. Responses received after the due date may not be reviewed. This is not a request for proposals (RFP) and the Government is not committed to award a contract pursuant to this announcement. If this program is approved for implementation and it is determined to be a small business set aside, then a competitive RFP will be available in FedBizOpps.
- Record
- SN01316328-W 20070614/070612220418 (fbodaily.com)
- Source
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FedBizOpps Link to This Notice
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