SPECIAL NOTICE
B -- CLINICAL RESEARCH SUPPORT SERVICES
- Notice Date
- 7/25/2007
- Notice Type
- Special Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- NHLBI-PB-(HL)-2007-205-DDC
- Response Due
- 8/3/2007
- Archive Date
- 8/18/2007
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute?s (NHLBI) Office of Acquisition (OA), intends to negotiate and award a purchase order on a noncompetitive sole source basis to the Ahmadu Bello University Teaching Hospital-Abuth, PMB 1026 Shika Zaria, Kaduna State, Nigeria, to continue to provide clinical research support services for the Prevalence of Secondary Pulmonary Arterial Hypertension (PAH) in Patients with Sickle Cell Disease in Nigeria and the Role of HIV/AIDS and Endemic Parasitic Infections in the Natural History of Pulmonary Hypertension in Sickle Cell Disease study. Sickle cell disease (SCD) is an autosomal recessive disorder and the most common genetic disease in the world. SCD is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. Secondary pulmonary arterial hypertension (PAH) has been shown to have a prevalence of 30% in patients with SCD with mortality rates of 40% at 40 months after diagnosis in the United States. The burden of disease of SCD is highest in Nigeria (West Africa) where approximately 4% of the 140 million people in that country are homozygous for SCD, but the prevalence and outcomes of pulmonary hypertension in Africa have not been investigated. Many known infectious risk factors for PAH are also highly prevalent in Nigeria, including Human Immune Deficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), malaria, chronic hepatitis B and C, schistosomiasis and hookworm. The first clinical hypothesis is that interactions between these infectious complications and sickle cell related hemolysis would lead to an even higher prevalence of PAH in Nigeria.. The study is therefore designed to determine the prevalence of PAH in Nigerian patients with SCD using echocardiographic measurements of the tricuspid regurgitant jet velocity. The Government aim to determine the associations and epidemiological interactions that might lead to PAH, of endemic infectious disease co-morbidities, especially HIV/AIDS, with SCD by screening for these infectious diseases in control subjects and in SCD patients with and without PAH. This study will involve collaboration between the USA NIH and Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria. A major organ complication of SCD is secondary pulmonary arterial hypertension (PAH). Many known infectious risk factors for (PAH) are also highly prevalent in Nigeria, including Human Immuno Deficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), malaria, chronic hepatitis B and C, schistosomiasis and hookworm. The overall goal of this project is to determine the prevalence of secondary, pulmonary hypertension in Nigerian patients with sickle cell anemia. The project aims to determine the prevalence of HIV, malaria, hepatitis B and C, schistosomiasis and hookworm in Nigerian patients with sickle cell anemia, and the interaction of HIV, malaria, hepatitis B and C, schistosomiasis, hookworm, and sickle cell anemia in (PAH) in Nigerian patients with sickle cell anemia. And to confirm a genetic diagnosis for sickle ?-globin syndromes and ?-thalassemia syndromes in this cohort as a point of reference for future genotype-phenotype studies, and using both candidate gene and genome wide association approaches, NHLBI along with ABUTH will identify and selectively characterize single nucleotide polymorphisms (SNPs) in genes important for endothelial function and vascular inflammation, and identifying genetic proteomic risk factors associated with pulmonary hypertension in SCA using this study?s genotyping approaches. The sole source determination is based upon the fact that the Ahmadu Bello University Teaching Hospital(ABUTH) in Zaria, Nigeria is the only known source that is currently able to assist the NIH, NHLBI, Vascular Medicine Branch in this area of research. An award to any other source would result in a substantial duplication of cost to the Government that is not expected to be recovered through competition. The expected period of performance is one (1) month from the date of the award. This acquisition is being conducted under simplified acquisition procedures and is exempt from the requirement of Federal Acquisition Regulations (FAR) Part 6, Competition Requirements. The North American Industry Classification System (NAICS) applicable to this requirement is 541990 with a size standard of $6.5 M. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely with the discretion of the Government. Comments to this announcement, referencing synopsis number NHLBI-PB(HL)-2007-205-DDC, may be submitted to the National Heart, Lung, and Blood Institute, Office of Acquisition, Procurement Branch, 6701 Rockledge Drive, Suite 6042, Bethesda, MD 20892-7902, Attention: Deborah Coulter. Responses may be submitted electronically to coulterd@nhlbi.nih.gov or hawkinsd@nhlbi.nih.gov and by fax to (301) 480-3345. Responses will only be accepted if dated and signed by an authorized company representative. Point of Contact Deborah Coulter, Contract Specialist, Phone (301) 435-0368, Fax (301) 480-3345, Email dc143b@nih.gov - Debra Hawkins, Chief, Procurement Branch, Phone (301) 435-0367, Fax (301) 480-3345, Email dh41g@nih.gov.
- Place of Performance
- Address: BETHESDA MD
- Zip Code: 20892-7902
- Country: UNITED STATES
- Zip Code: 20892-7902
- Record
- SN01351713-W 20070727/070725220703 (fbodaily.com)
- Source
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