SOLICITATION NOTICE
A -- Request for Proposals for Preclinical Studies of Small Molecules with Therapeutic Potential for Spinal Muscular Atrophy
- Notice Date
- 9/7/2007
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Science Applications International Corporation (SAIC)(NINDS Prime Contractor), 5340 Spectrum Drive, Suite N, Frederick, MD, 21703-7357, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- LD-090707
- Response Due
- 10/5/2007
- Archive Date
- 10/20/2007
- Description
- The SMA Project (http://www.smaproject.org) seeks to identify facilities to conduct preclinical testing of chemical compounds with the ultimate goal of submitting an Investigational New Drug (IND) application to the U.S. Food and Drug Administration. Studies to be conducted under the resulting contract will include preclinical safety, toxicology, pharmacokinetic/dynamic, and biodistribution studies with candidate small molecule compounds that act as therapeutic agents for spinal muscular atrophy (SMA). While a broad range of Good Laboratory Practice (GLP) and non-GLP studies is anticipated, capability to conduct studies according to GLP is required. Science Applications International Corporation (SAIC), on behalf of the Government, shall supply the Offeror with a small amount of each candidate therapeutic compound. For certain compounds provided to the Contractor, SAIC may request a comprehensive Product Development Plan for services to be provided by the Contractor. Facilities will be evaluated on their past experience in preclinical, IND-directed small molecule development, as well as the proposed schedule and cost of studies required. Offers are due by 3 p.m. Eastern Time on October 5, 2007. The Request for Proposals and relevant documents can be accessed through the Solicitations page of the SMA Project website at http://www.smaproject.org/solicitations.html. The National Institute for Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov/) launched The SMA Project: A Collaborative Program to Accelerate Therapeutics Development for Spinal Muscular Atrophy in September 2003. This program funds milestone-driven research aimed at identifying and rapidly developing a treatment for SMA, a paralyzing neurodegenerative disease of childhood. SAIC is supporting the NINDS in the management of this program. Any responsible Offeror may submit a proposal to be considered by SAIC.
- Place of Performance
- Address: Offeror's facilities
- Zip Code: 00000
- Country: UNITED STATES
- Zip Code: 00000
- Record
- SN01398503-W 20070909/070907220734 (fbodaily.com)
- Source
-
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