SPECIAL NOTICE
A -- TECHNOLOGY/BUSINESS OPPORTUNITY Probe-Based Molecular Signal Delivery
- Notice Date
- 6/11/2008
- Notice Type
- Special Notice
- NAICS
- 238990
— All Other Specialty Trade Contractors
- Contracting Office
- Department of Energy, Lawrence Livermore National Laboratory (DOE Contractor), Industrial Partnerships & Commercialization, 7000 East Avenue, L-795, Livermore, California, 94550
- ZIP Code
- 94550
- Solicitation Number
- FBO182-08
- Response Due
- 7/11/2008
- Archive Date
- 7/12/2008
- Point of Contact
- Connie L Pitcock, Phone: 925-422-1072
- E-Mail Address
-
pitcock1@llnl.gov
- Small Business Set-Aside
- N/A
- Description
- TECHNOLOGY/BUSINESS OPPORTUNITY Probe-Based Molecular Signal Delivery Opportunity : Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract with the U.S. Department of Energy (DOE), is offering the opportunity to license and commercialize new technology using probe-based molecular signal delivery for precise control and measurement of single cell response. Background : Pathogens have unique ways of bypassing and exploiting normal cellular events to infect host cells. Many pathogenic bacteria can produce proteins that can mimic natural host cell ligands. For example, Listeria monocytogenes, is a rare, but deadly food-borne illness that has a mortality rate of 25%. Listeria invades cells by targeting and binding to receptors on the host cell's surface triggering endocytosis. Understanding how an organism's cells respond to molecules and signals derived from foreign sources will enable the development of new strategies for detection and therapeutic intervention. Description : The invention covers a probe-based signal delivery to individual cells. •· LLNL has developed a method of delivering precise amounts of signal molecule to a cell surface. LLNL is capable of monitoring the effect through: 1) activation of the probe with a signal type; 2) spatial and temporal control of the probe by user; 3) immobilization of the target cell upon a substrate; and 4) method to monitor the response on the cell. Advantages : This new technology offers the following potential advantages over existing technology: •· Enables precise molecular control and characterization of bacterial internalization or pharmaceutical engagement by a single-host cell •· Real-time tracking of dynamic invasion process with an unambiguous initiation •· Increased ability to determine effectiveness of molecular treatments in blocking infection of cells •· High sensitivity method to independently calibrate other pathogen detection technologies Potential Applications : The most immediate application allows for the control of signal input to individual cells that will enable a variety of pharmaceutical, medical and biosecurity discoveries and applications. Development Status : A high sensitivity is achieved with the described method. A bacterial invasin called InlA is functionalized onto a probe and contacts a cell with green-labeled Actin at time t=0. In 35 seconds, a rearrangement of the Actin is imaged in real time, and after 100 seconds, a maximum Actin signal is recorded. We are looking for a partner to help develop the technology. You can also state any additional needs - e.g. if we are looking for a partner to help develop technology. Intellectual Property: Currently, LLNL is in the process of preparing and filing a patent application covering this technology. LLNL is seeking industry partners with a demonstrated ability to bring such inventions to the market. Moving critical technology beyond the Laboratory to the commercial world helps our licensees gain a competitive edge in the marketplace. All licensing activities are conducted under policies relating to the strict nondisclosure of company proprietary information. Please visit the IPO website at http://ipo.llnl.gov/workwithus/partneringprocess.php for more information on working with LLNL and the industrial partnering and technology transfer process. Note: THIS IS NOT A PROCUREMENT. Companies interested in commercializing LLNL's probe-based molecular signal delivery for precise control and measurement of single cell response should provide a written statement of interest, which includes the following: 1. Company Name and address. 2. The name, address, and telephone number of a point of contact. •3. A description of corporate expertise and facilities relevant to commercializing this technology. Written responses should be directed to: Lawrence Livermore National Laboratory Industrial Partnerships Office P.O. Box 808, L-795 Livermore, CA 94551-0808 Attention: FBO 182-08 Please provide your written statement within thirty (30) days from the date this announcement is published to ensure consideration of your interest in LLNL's technology.
- Web Link
-
FedBizOpps Complete View
(https://www.fbo.gov/?s=opportunity&mode=form&id=f3604928799128bc9e2355b6224c0f45&tab=core&_cview=1)
- Record
- SN01590955-W 20080613/080611221115-f3604928799128bc9e2355b6224c0f45 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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