SOLICITATION NOTICE
66 -- EnVision Xcite Multilabel Reader
- Notice Date
- 7/8/2008
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-80114-MM
- Archive Date
- 8/6/2008
- Point of Contact
- Melissa P Marino, Phone: 301-402-4509, Caren N Rasmussen,, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Laboratory of Molecular Pharmacology, plans to procure on a sole source basis for an upgrade to a PerkinElmer EnVision Xcite plate reader with PerkinElmer 710 Bridgeport Avenue, Shelton CT 06484-4794. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR 13.106-(b)(1) The North American Industry Classification System Code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this announcement. The following salient characteristics apply to the PerkinElmer EnVision Xcite: •Capable of detecting the following signals: - Absorbance (UV and Visible) - Fluorescence Intensity (FI and FRET) - Luminescence (Standard or Enhanced) - Time Resolved Fluorescence (DELFIA, LANCE, TruPoint) - Fluorescence Polarization - AlphaScreen (Amplified Luminescent Proximity Homogenous Assay) •PMT (photo multiplier tube) based microplate reader that has optimized dichroic mirror blocks specific to each label (i.e. detection chemistry), which ensures maximum sensitivity in all read modes; •Full lens system without any light guides or fiber optic bundles; •Easily accessible, excitation (8) and emission (8) filters that are all individually barcoded in order to prevent the possibility of an end user from reading a plate with the wrong filters. The operational software needs to automatically detect the barcoded filters and optical modules that are installed and available for assay reading. •Offer barcoded dichroic mirror modules and the system needs to be able to hold up to 5 optimized dichroic mirror modules simultaneously. The modules for top reading can be switched back and forth automatically and the bottom dichroic module needs to be easily changeable from an access panel on the side of the instrument. •End user shall be able to simply add the application-specific optical module (mirror) and filters specific to his/her label of interest in order to add additional read modes to the system. No service personnel shall be necessary to modify the hardware •Offer an automatic height sensor, that will ensure that every time a microplate is loaded, the plate height is correct for the assay about to be read which prevents all potential damage to valuable samples and the instrument. •Software needs to be a browser-based, Windows (2000 or XP) platform that is very user friendly and simple to use. It needs to offer an easy to use optimization wizard feature that guides each end user through the process of defining plate dimensions, measurement heights, and gains specific for his/her assay insuring the maximum sensitivity and dynamic range. •Must be compatible with AlphaScreen detection technology (Amplified Luminescent Proximity Homogenous Assay), Absorbance (UV and Visible), Fluorescence Intensity (FI and FRET), Luminescence (Standard or Enhanced), Time Resolved Fluorescence (DELFIA, LANCE, TruPoint), Fluorescence Polarization. The plate reader shall include both a TRF laser and an enhanced luminescence module for enhanced sensitivity. • Must have a specific software with an easy to use optimization wizard feature that guides each end user through the process of defining plate dimensions, measurement heights, and gains specific for his/her assay insuring the maximum sensitivity and dynamic range. The contractor shall offer dedicated, worldwide team of sales, applications, technical support and service professionals that shall help the end user before, during and after purchase. JUSTIFICATION: 1.Statutory authority: Statute: 13.106-(b)(1) and 13.501(a)(1) (b) Soliciting from a single source. (2) For Sole source acquisition of commercial items in excess of the simplified acquisition threshold conducted pursuant to subpart 13.5, the requirements at 13.501(a) apply. The Envision Xcite is a universal open-format plate reader that reads all non-isotopic detection technologies including fluorescence intensity, fluorescence polarization, time-resolved fluorescence, luminescence, absorbance and AlphaScreen with high sensitivity and reading speed (only 32 sec for a 1536-well plate). We wish to translate our two HTS assays for Tdp1 and HIV-1 integrase inhibitor discovery to the AlphaScreen technology. The EnVision Instrument is the only laboratory system available that has been optimized to measure AlphaScreen. In addition to its screening capacity, the Envision can be used for fluorescence polarization and time-resolved fluorescence which will enable us to perform new drug mechanism of action studies. The Envision plate reader represents the state of the art in multilabel detection. PerkinElmer is the only known source that is capable of meeting all the needs of the NCI. This is not a solicitation for competitive quotations. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 1:00 PM ET on July 22, 2008. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Melissa Marino, Contract Specialist at marinome@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-80114-MM on all correspondence.
- Web Link
-
FedBizOpps Complete View
(https://www.fbo.gov/?s=opportunity&mode=form&id=53f1091b79c1556bd9c37bebc009531a&tab=core&_cview=1)
- Record
- SN01609077-W 20080710/080708221720-53f1091b79c1556bd9c37bebc009531a (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |