SOLICITATION NOTICE
B -- Multiscale Lung Cancer Policy Model
- Notice Date
- 8/22/2008
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-80200-NG
- Archive Date
- 9/17/2008
- Point of Contact
- Ashley L. Virts, , Malinda L Holdcraft,, Phone: (301) 402-4509
- E-Mail Address
-
virtsa@mail.nih.gov, holdcram@exchange.nih.gov
- Small Business Set-Aside
- N/A
- Description
- National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS), Surveillance Research Program, Statistical Research and Applications Branch intends to procure on a sole-source basis with the Massachusetts General Hospital Institute for Technology Assessment; 101 Merrimac Street, 10th floor; Boston, MA 02114-4724 for services regarding a Multiscale Lung Cancer Policy Model. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.501. The North American Industry Classification System Code is 541712 and the business size standard is 500 employees. Period of performance: September 30, 2008 through March 30, 2009. The Massachusetts General Hospital’s Institute for Technology Assessment (ITA) is an affiliate member of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Group, which focuses on modeling population trends. The ITA team has developed a Lung Cancer Policy Model (LCPM) to investigate the effectiveness and cost-effectiveness of cancer control interventions, including screening strategies. As part of the ICBP program, the Center for the Development of a Virtual Tumor (CViT) team has developed a multiscale NSCLC model for EGFR-ERK signaling path way of NSCLC within an in silico microenvironment. The ITA team has initiated preliminary work on developing a reaction-diffusion model (more specifically, a growth model based on Cahn-Hilliard equations) to improve the spatial resolution of tumor growth for population-based screening models. This component will utilize the output from the CViT NSCLC model to inform the tumor growth trajectory for the LCPM. The goal is to create a lung cancer model with individual NSCLC patients’ biochemical details such as their responses to external stimuli, the underlying properties of signaling networks, and cellular biological responses, and improved spatial resolution for lung cancer screening. The contractor shall: 1. Integrate a CViT NSCLC model into the ITA LCPM. 2. Contractor shall make necessary coding changes to the model and perform simulations to generate outputs. The technical details of model integration will be documented. The mission of the Massachusetts General Hospital (MGH) Institute for Technology Assessment (ITA) is to conduct health outcomes research to guide the development, evaluation and utilization of medical technologies that improve the quality and cost-effectiveness of medical care. The Center for the Development of a Virtual Tumor (CViT), brings together a multi-institutional, interdisciplinary group of investigators with interest in the biomedical, the computational and the mathematical aspects of cancer research. CViT’s long term goal is to develop a generic, module-based tool-kit for modeling and simulating selected cancer types of interest such as breast, brain, lung cancer, and melanoma following a paradigm-shifting cross-disciplinary complex systems approach. Combined with cutting edge biomedical data, the modeling tool-kit will have significant value for experimental cancer research as it allows researchers to properly study cancer initiation and such critically linked progression features as invasion, angiogenesis and metastasis in the context of an emergent system. Ultimately, the tool-kit will also have important clinical applications including trial design and management as well as patient outcome predictions. Both the Massachusetts General Hospital (MGH) Institute for Technology Assessment (ITA) and The Center for the Development of a Virtual Tumor CViT teams are located at MGH, a unique environment with expertise in both population level lung cancer modeling and subcellular/cellular level modeling of non-small cell lung cancer. The close connection between the two teams is imperative for collaboration with the model integration process and therefore Massachusetts General Hospital (MGH) Institute for Technology Assessment (ITA) is the only source known to the NCI capable of performing the work outlined in the procurement. This is not a solicitation for competitive quotations. However, if any interested party believes it can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 1:00 PM EST on September 2, 2008. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Malinda Holdcraft, Contract Specialist at holdcram@exchange.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-80200-NG on all correspondence.
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