SOLICITATION NOTICE
B -- Radiation dosimetry support for radiation epidemiology studies of medical personnel and patients
- Notice Date
- 12/17/2008
- Notice Type
- Presolicitation
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90032-KM
- Archive Date
- 1/17/2009
- Point of Contact
- Karri L. Mares,, Phone: 3014357774, Caren N Rasmussen,, Phone: (301) 402-4509
- E-Mail Address
-
maresk@mail.nih.gov, cr214i@nih.gov
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Radiation Epidemiology Branch (REB), Division of Cancer Epidemiology and Genetics (DCEG), plans to procure on a sole source basis Radiation dosimetry support for radiation epidemiology studies of medical personnel and patients with Kyung Hee University, 1 Seocheon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, Korea. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1 (b)(1). The North American Industry Classification System code is 611310 and the business size standard is 7.0 M employees. The Radiation Epidemiology Branch (REB) within the National Cancer Institute (NCI) plans to carry out studies to characterize the risk of radiation-induced cancer in terms of tissues at risk, dose response, biological effectiveness, dose rate, time since exposure, sex, age at exposure and at observation, and possible modifying influences of other environmental and host factors. With regard to the medical setting, case-control and cohort studies of cancer risk are conducted in patient populations exposed to diagnostic x rays, Computed Tomography (CT) scans, fluoroscopic and other procedures, and in groups of patients treated with radiotherapy alone or in combination with chemotherapy and other forms of treatment. For the overall contract, the contractor shall: Provide services to support REB research activities in the areas of radiation-induced cancer risk among medical personnel involved in FG procedures, of risk projection among patients with CT scans, and epidemiologic studies of cancer risks of pediatric patients arising from the use of CT scans. Provide recommendations, guidance, and information on occupational and patient medical radiation exposure and approaches for their dose assessment. Provide leadership in estimating radiation doses in support of REB epidemiologic studies. Provide supporting dosimetric data analysis for relating the exposure to cancer risk in the studies identified above. Have a health physicist with a Ph.D. in radiation dosimetry and experience in medical dose assessment for radiation epidemiologic studies and must have been trained in medical physics and have at least three publications in peer-reviewed scientific journals that would demonstrate full understanding of medical radiation sources and their physics, knowledge of radiation dosimetry, ability to analyze measurement data, and skill to calculate radiation doses Employ a part-time assistant or a graduate student to support the health physicist’s activity Maintain the appropriate office space, computer and other equipment, and infrastructure for effectively carrying out the activities set forth in this statement of work. Travel to NCI 4 times per year during the base year and 3 times per year during option years 1 & 2 for 1 week each time. During this time, the contractor shall occupy an office provided by NCI and will be available to provide clarifications on various aspects of research work accomplished by the contractor. <ins datetime="2008-12-12T10:25" cite="mailto:NCI%20User"></ins> Base Year-FG Procedure Study: <!--[if !supportLists]--> · <!--[endif]--> Estimate cumulative doses received by cardiologists performing FG procedures. The available radiation dose estimates per procedure shall be used to calculate cumulative doses assuming annual caseloads for the cardiologists. <!--[if !supportLists]--> · <!--[endif]--> Perform a systematic review study of occupational doses during FG procedures other than cardiac procedures, including biliary procedures, endoscopic retrograde cholangiopancreatography (ERCP), transjugular intrahepatic portosystemic shunt (TIPS), orthopedic nailing, percutaneous nephrolithotomy (PCNL), head and neck vascular procedures, and vertebroplasty. <!--[if !supportLists]--> · <!--[endif]--> Analyze annual nationwide badge dose data by medical specialty, including radiologists, cardiologists, and other physicians during the period 1977-2004. Base Year-CT Risk Projection Study: <!--[if !supportLists]--> · <!--[endif]--> Estimate the organ-specific radiation doses and associated cancer risks from coronary artery calcification (CAC) screening by multi-detector computed tomography (MDCT). The REB’s lifetime risk calculator (IREP-RISK) shall be used for cancer risk estimation <!--[if !supportLists]--> · <!--[endif]--> Estimate organ-specific radiation doses from all common types of CT scans assuming current level of CT scan parameter settings in the U.S. <!--[if !supportLists]--> · <!--[endif]--> Estimate organ-specific radiation doses from CT colonography (CTC) screening. <!--[if !supportLists]--> · <!--[endif]--> Estimate the potential organ-specific radiation doses from lung CT performed on patients with cystic fibrosis. The estimated organ doses will be used by a REB investigator to estimate the risk of radiation-induced cancer from CT. Base Year-Pediatric CT Study: <!--[if !supportLists]--> · <!--[endif]--> Review currently available CT dosimetry methods and databases and compare radiation doses from different dosimetric approaches. <!--[if !supportLists]--> · <!--[endif]--> Estimate organ-specific radiation doses to the cohort members who had CT scans in the northern region of the UK. This region represents about 8% of the cohort. <!--[if !supportLists]--> · <!--[endif]--> Develop detailed dosimetry methods for the cohort study. <!--[if !supportLists]--> · <!--[endif]--> Provide dosimetry consultations on other studies (e.g., Israeli) of cancer risk resulting from CT exposure, which are collaborating with NCI investigators. Provide consultations to other CT studies upon request by NCI. Option Year 1 <!--[if !supportLists]--> · <!--[endif]--> Estimate organ-specific doses to the approximately 200,000 cohort members, based on the dosimetry methods established during the base year. The organs and tissues that are currently considered include, but may not be restricted to, bone marrow, brain, thyroid, and breast. <!--[if !supportLists]--> · <!--[endif]--> For the purpose of estimating organ-specific radiation doses, analyze 333 pilot data from Newcastle University, which include CT scan parameter settings abstracted from CT film as well as electronic radiology records of patients. <!--[if !supportLists]--> · <!--[endif]--> On the basis of the experience acquired during the analysis of the 333 pilot data from Newcastle, establish specific dosimetry methods for the subjects of the nested case-control study. <!--[if !supportLists]--> · <!--[endif]--> Provide dosimetry consultations on other studies (e.g., Israeli) of cancer risk resulting from CT exposure, which are collaborating with the NCI study. Provide consultations to other CT studies upon request by NCI. <!--[if !supportLists]--> · <!--[endif]--> Respond to requests from NCI scientists regarding the dosimetry aspects of the FG procedure study (approximately 30% of time on contract) and of the CT risk projection study (approximately 20% of time on contract). Option Year 2: CT Study only <!--[if !supportLists]--> · <!--[endif]--> Estimate organ-specific doses of each subject enrolled in the nested case-control study by applying the specific dosimetry methods established during the option year 1. The only tissue that is currently considered is bone marrow; other tissues or organs may be added, depending on the outcome of the cohort study. <!--[if !supportLists]--> · <!--[endif]--> Provide dosimetry consultations on other studies (e.g., Israeli) of cancer risk resulting from CT exposure, which are collaborating with the NCI study. Provide consultations to other CT studies upon request by NCI. Period of Performance shall be twelve months from date of award plus two (2) one-year option periods. Kyung Hee University in Seoul, South Korea, in its Department of Nuclear Engineering, includes a program of formation of health physicists, specializing in the assessment of radiation doses. The teaching staff of Kyung Hee University now includes Prof. KwangPyo Kim, who was previously associated with the Intramural Research program of REB at the NCI. During his time at the NCI, Prof. Kim served as the main dosimetrist on each of the studies covered by this request. Therefore, Kyung Hee University can provide a consultant who is not only familiar with the overall research at REB, but also possesses an in-depth knowledge of each of the studies involved in this request. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can meet this requirement. One (1) original and one (1) copy of the capability statement must be received in the contracting office by 11: 00 a.m. EST on January 2, 2008. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to Karri Mares maresk@mail.nih.gov. It is the vendor’s responsibility to ensure questions have been received by the contract specialist. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractor must have valid, updated registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Application (ORCA). Please reference solicitation No. NCI-90032-KM on all correspondence.
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