SOLICITATION NOTICE
66 -- TaqMan Human microRNA Array A&B
- Notice Date
- 6/15/2009
- Notice Type
- Presolicitation
- NAICS
- 325413
— In-Vitro Diagnostic Substance Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90105-MM
- Archive Date
- 7/14/2009
- Point of Contact
- Melissa P Marino, Phone: 301-402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
(marinome@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Laboratory of Translational Genetics intends to procure on a sole source basis the TaqMan Human microRNA Array A & B with Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-(b)(1). The North American Industry Classification System Code is 325413 and the business size standard is 500. Only one award will be made as a result of this solicitation. The overall goal of our laboratory is to develop new approaches to the study of the genetic basis of cancer and its outcomes. Specifically, we will investigate the genetic basis of strong association signals identified in candidate gene association studies, loci identified by linkage analyses in high-risk families, or genome-wide association studies (GWAS), particularly the loci identified by the ongoing Cancer Genetic Markers of Susceptibility (CGEMS) program. This research utilizes molecular biology immunological, genetic and biochemical technologies. The contractor shall provide 50 Taqman MicroRNA Assay Array Cards. Salient Characteristics required of the TaqMan Human microRNA Array A & B are: 1.Reaction vessel uses microfluidic technology in a 384-well plate format. 2.The reaction vessel has 8 sample loading ports and must use centrifugation to distribute the samples into each of the 48 wells serviced by each port. 3.The reaction vessel is compatible with the Applied Biosystems 7900HT Sequence Detection System (a real-time PCR instrument). 4.The reaction vessel is pre-loaded with pre-designed 5'-nuclease assays using TaqMan® probes. Applied Biosystems is the only known source for the TaqMan MicroRNA Assay Array Cards. Use of a different platform would result in a decrease of sensitivity and specificity. Further, alternate platforms would require procurement of additional costly equipment. Applied Biosystems technology is the only real time quantitative PCR method authorized to use microRNA TaqMan for: a. High specificity (single base pair discrimination of mature miRNA); b.Sensitivity (single copy of target) c. Linear Dynamic Range (7-9 logs of linear dynamic range) d.Ease of use: Easily implementable on existing 7900HT, with only 2 steps that take approximately 3-10 minutes total hands on time average per sample when operating in high throughput (15-30 minutes per sample hands on time in low throughput vs hours with microarrays) e. Low sample input: Ability to assess single cells or low cell population (Non-biased assessment of single cells with the TaqMan Array). Ability to do Laser Capture Microdissection (LCM), FFPE (Formalin Fixed Paraffin Embedded) tissues, and every other tissue with minimally 1 cell and no limitation on abundent sample. f. Highly parallel miRNA profiling/detection This is not a solicitation for competitive quotations. However, if any interested party believes it can meet the above requirement, they may submit a statement of capabilities. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office on or before 11:00 AM EST on June 29, 2009. All questions must be in writing and can be faxed to (301) 402-4513 or emailed to Melissa Marino, Contract Specialist at marinome@mail.nih.gov. It is the vendor's responsibility to call (301) 402-4509 to verify questions have been received. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration/certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference solicitation number NCI-90105-MM on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-90105-MM/listing.html)
- Record
- SN01845478-W 20090617/090615235534-c70a307900ed67129fb565cc6a3ac633 (fbodaily.com)
- Source
-
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