SOLICITATION NOTICE
B -- Breast and colorectal cancer trends as a function of menopausal hormone therapy (MPH) and cancer screening among female members of the two large health plans in the United States
- Notice Date
- 7/20/2009
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90131-KM
- Archive Date
- 8/19/2009
- Point of Contact
- Karri L. Mares, Phone: 3014357774, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
maresk@mail.nih.gov, cr214i@nih.gov
(maresk@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Hormonal and Reproductive Epidemiology Branch (HREB) plans to procure on a sole source basis Breast and colorectal cancer trends as a function of menopausal hormone therapy (MPH) and cancer screening among female members of the two large health plans in the United States with Kaiser Permanente Northern California (KPNC); 1800 Harrison St., FL 16; Oakland, California 94612-3433. This acquisition will be conducted under the procedures for acquiring commercial items authorized in FAR Part 12 and under the authority to use simplified procedures for commercial requirements as provided in FAR 13.501.The North American Industry Classification System code is 541990 and the business size standard is $7.0 million. The unprecedented decline in U.S. female breast cancer incidence rates after 2002 may be caused by the reduced use of menopausal hormone therapy (MHT), a known risk factor for breast cancer. The HREB lab has attempted to uncover an explanation for the change in rates, and earlier ecologic analyses strongly pointing to reduced use of MHT among women as the most likely cause of the recent decline in incidence rates. However, ecologic analyses are subject to particular bias and the ecologic fallacy, and even a methodologically strong ecologic analysis will not be able to sufficiently identify the likely cause of the recent change in incidence rates. The best method for pursuing these questions is to utilize existing data from managed health care settings. The purpose of this procurement is to finalize age-specific breast cancer incidence rates and rate trends among specific subgroups of women defined by MHT use and screening mammography, accounting both for specific equivalent MHT types over time and potential pre-invasive breast neoplasias; identify whether any known or suspected breast cancer risk factors are associated with recent changes in MHT use or mammographic screening behavior to the extent that might operate as important confounders of observed changes in rates; and, based on summary final data to emerge from this project, collaborate with NCI’s CISNET group to develop or test population-based statistical models that evaluate the influence of MHT use on the natural history of breast cancer and the influence of MHT cessation on breast cancer incidence rates. Period of Performance shall be twelve months from date of award. KPNC has a large membership base to include sufficient numbers of women ages 45 years or older (an estimated 650,000) to, when combined with the Kaiser Permanente Northwest (KPNW) population, provide stable and reliable analysis of recent trends in incidence rates according to MHT use and screening behavior. Existing etiologic studies within the NCI’s DCEG are individually too small to accomplish this aim and collectively too disparate to justify effectively pooling the data. KPNS has regional offices throughout the U.S. with databases, data procedures, and data quality that can be easily searched, using algorithms, codes, and operational definitions developed by the NCI and KPNW, with input from KPNC, to generate extensively detailed data on individual members’ histories of MHT use, screening behavior, and subsequent cancer incidence. KPNC investigators have experience conducting analyses that are relevant to the questions under study here, and the KPNC investigators have the knowledge of the specific critical KPNC data that will be used for this analysis. KPNC is the only known contactor to the NCI who can perform the required tasks. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can meet this requirement. One (1) original and one (1) copy of the capability statement must be received in the contracting office by 11: 00 a.m. EST on 8/4/2009. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to Karri Mares maresk@mail.nih.gov. It is the vendor’s responsibility to ensure questions have been received by the contract specialist. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractor must have valid, updated registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Application (ORCA).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-90131-KM/listing.html)
- Record
- SN01881419-W 20090722/090721000342-3e83feda172776622340c47744bbb1be (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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