SOLICITATION NOTICE
66 -- AKTA 10 Purifier
- Notice Date
- 7/24/2009
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90138-AV
- Archive Date
- 8/21/2009
- Point of Contact
- Ashley L. Virts,
- E-Mail Address
-
virtsa@mail.nih.gov
(virtsa@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Laboratory of Cellular and Molecular Biology (LCMB), plans to procure the brand name AKTA Purifier 10 Fast Protein Liquid Chromatography System (FPLC) manufactured GE Healthcare Bio-Sciences Corp., 800 Centennial Avenue, P.O. Box 1327, Piscataway, NJ 08855. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR 13.106-(b)(1) The North American Industry Classification System Code is 334516 and the business size standard is 500 employees. Part I -Background Information and Description of the Requirement The Laboratory of Cellular & Molecular Biology (LCMB), studies Arf GAP proteins related to tumor invasion, in particular ASAP1, ASAP3 and AGAP1/2 proteins and compares these to Arf GAPs involved in constitutive membrane traffic such as Arf GAP 1. The principle aim of the enzymological studies is to determine catalytic differences between Arf GAPs that have been implicated in cancer and those that have constitutive activities in cells, with the goal of developing therapeutics that target the Arf GAPs. This work is highly dependent on purifying proteins using chromatography instruments. Both recombinant and endogenous proteins are purified from a variety of sources using state of the art chromatography materials. All methods have been developed over the past 15 years using equipment and supplies available through GE-Healthcare. Because the chromatography media are proprietary, purification schemes would have to be redeveloped if we were to use supplies and equipment from another company, which could take months to years. Therefore, purchase of a chromatography instrument that is compatible with the other GE Healthcare instruments in the laboratory is critical to ensure that work will be consistent and not be interrupted by equipment failure. Part II - Facts and Reasons to Justify Other than Full and Open Competition 1. Statute: This justification has been prepared under the authority of 41 U.S.C.253 (c)(1) as set forth in 13.106-1 (b)(1). (b) Soliciting from a single source. (1)For purchases not exceeding the simplified acquisition threshold, contracting officers may solicit from one source if the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, or industrial mobilization. No other requirement and/or type for supply or service will satisfy agency need. The following Salient Characteristics apply to the AKTA 10 Purifier FPLC: • Compatible with the existing systems in the laboratory • Capacity to purify proteins •A required flow rate range of 0.001-10 mls/min at pressures ranging from 0-25 MPa (0325 psi) •Must be a twp-pump gradient system with dynamic mixing Justification The utilization of salt buffers requires the entire wetted flow path of the system be inert to halides. The pump heads must be titanium with valves and tubing in PEEK. The system pumps should allow operation of the system at zero backpressure to ensure system compatibility with standard low-pressure chromatography supports often used in affinity chromatography and other techniques. The controller must allow programs to be time-based, volume-based, or column-volume based. The system must include a motorized valve for sample injection. In order to facilitate cleaning, storage, selection of our various chromatographic columns, and further automation the system must have the ability to control 8 more motorized valves for a total 9 motorized valves. This is necessary for buffer selection, injection, flow diversion, diverting peaks to sample loops etc. Also, the motorized valves should provide feedback to the control system to ensure proper orientation of all valves, and documentation of valve positions at all times. The valves should be driven electronically and require no external air or pressure to operate. GE Healthcare Bio-Sciences is the manufacturer of the AKTA Purifier 10 FLPC which is the only system known to the NCI capable of performing the tasks outlined in this procurement. For these reasons, NCI has deemed GE Healthcare to be sole source provider for this acquisition. This is not a solicitation for competitive quotations. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 1:00 PM ET on August 6, 2009. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Ashley Virts, Contract Specialist at virtsa@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-90138-AV on all correspondence.
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- SN01887199-W 20090726/090725000943-d3ab4fb9656c5ad1c371bc313afce1f0 (fbodaily.com)
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